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IID00658
 UniprotP43355
ProteinMelanoma-associated antigen 1
GeneMAGEA1
OrganismHomo sapiens
Sequence LLPS PhaSepDB
PhaSePro
LLPSDB
DrLLPS
 Network xml rdf
Structure
Experiment
  :order   disorder   conflict   PDB cluster   ProS   Pfam Domain   SEG
309
 order/disorder by at least rule
     disorder by at least rule
     order by at least rule
 order/disorder by majority rule
Seq 161-169 Hetero trimer : P30443
 Evidence X-RAY 3bo8 C Reference
       Region 3bo8 C 161-169 order
Seq 161-169 Hetero pentamer : P30443
 Evidence X-RAY 1w72 F Reference
       Region 1w72 F 161-169 order
Seq 161-169 Hetero pentamer : P30443
 Evidence X-RAY 1w72 C Reference
       Region 1w72 C 161-169 order
Seqphosphorylation
    57-57 Phosphoserine
 
Prediction
NeProc
Disorder 1-98,305-309
Order 99-304
ProS 1-29,73-81,305-309
AlphaFold
Disorder 1-89,184-187,289-294,307-309
Order 90-183,188-288,295-306
Pfam Hmmer
PF01454 3-224 1.3e-145
SEG 13-23 ,73-89 ,297-307
Function
Function in SwissProt
May be involved in transcriptional regulation through interaction with SNW1 and recruiting histone deactelyase HDAC1. May inhibit notch intracellular domain (NICD) transactivation. May play a role in embryonal development and tumor transformation or aspects of tumor progression. Antigen recognized on a melanoma by autologous cytolytic T-lymphocytes.