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IID00659
 UniprotP45973
ProteinChromobox protein homolog 5
GeneCBX5
OrganismHomo sapiens
Sequence LLPS PhaSepDB
PhaSePro
LLPSDB
DrLLPS xml
Structure
Experiment
  :order   disorder   conflict   PDB cluster   ProS   Pfam Domain   SEG
191
 order/disorder by at least rule
     disorder by at least rule
     order by at least rule
 order/disorder by majority rule
Seq 18-75 Hetero dimer :
 Evidence X-RAY 3fdt A Reference
       Region 3fdt A 18-68 order
       Region 3fdt A 69-75 disorder
Seq 110-173 Homo tetramer :
 Evidence X-RAY 3i3c A Reference
       Region 3i3c A 110-110 disorder
       Region 3i3c A 111-131 order
       Region 3i3c A 132-134 disorder
       Region 3i3c A 135-170 order
       Region 3i3c A 171-173 disorder
 Evidence X-RAY 3i3c B Reference
       Region 3i3c B 110-111 disorder
       Region 3i3c B 112-132 order
       Region 3i3c B 133-134 disorder
       Region 3i3c B 135-171 order
       Region 3i3c B 172-173 disorder
 Evidence X-RAY 3i3c C Reference
       Region 3i3c C 110-111 disorder
       Region 3i3c C 112-131 order
       Region 3i3c C 132-133 disorder
       Region 3i3c C 134-170 order
       Region 3i3c C 171-173 disorder
 Evidence X-RAY 3i3c D Reference
       Region 3i3c D 110-111 disorder
       Region 3i3c D 112-132 order
       Region 3i3c D 133-134 disorder
       Region 3i3c D 135-170 order
       Region 3i3c D 171-173 disorder
Seqphosphorylation
    14-14 Phosphoserine
    11-11 Phosphoserine
    13-13 Phosphoserine
    12-12 Phosphoserine
    95-95 Phosphoserine
    92-92 Phosphoserine
    97-97 Phosphoserine
Seqacetylation
    40-40 N6-acetyllysine
 
Prediction
NeProc
Disorder 1-18,80-116,180-191
Order 19-79,117-179
ProS 80-93,100-116
AlphaFold
Disorder 1-16,76-114,178-191
Order 17-75,115-177
Pfam Hmmer
PF00385 20-69 2.3e-22
PF01393 119-176 3.4e-39
SEG 10-19
Function
Function in SwissProt
Component of heterochromatin that recognizes and binds histone H3 tails methylated at 'Lys-9' (H3K9me), leading to epigenetic repression. In contrast, it is excluded from chromatin when 'Tyr-41' of histone H3 is phosphorylated (H3Y41ph). Can interact with lamin-B receptor (LBR). This interaction can contribute to the association of the heterochromatin with the inner nuclear membrane. Involved in the formation of functional kinetochore through interaction with MIS12 complex proteins.