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IID00662
 UniprotQ00610
ProteinClathrin heavy chain 1
GeneCLTC
OrganismHomo sapiens
Sequence LLPS PhaSepDB
PhaSePro
LLPSDB
DrLLPS xml
Structure
Experiment
  :order   disorder   conflict   PDB cluster   ProS   Pfam Domain   SEG
1675
 order/disorder by at least rule
     disorder by at least rule
     order by at least rule
 order/disorder by majority rule
Seq 1-364 Monomer :
 Evidence X-RAY 2xzg A Reference
       Region 2xzg A 1-357 order
       Region 2xzg A 358-364 disorder
 Evidence X-RAY 4g55 A Reference
       Region 4g55 A 1-357 order
       Region 4g55 A 358-364 disorder
Seqphosphorylation
    67-67 Phosphoserine
    105-105 Phosphothreonine
    184-184 Phosphotyrosine
    394-394 Phosphothreonine
    634-634 Phosphotyrosine
    899-899 Phosphotyrosine
    1167-1167 Phosphoserine
    1206-1206 Phosphotyrosine
    1229-1229 Phosphoserine
    1477-1477 Phosphotyrosine
    1487-1487 Phosphotyrosine
    1494-1494 Phosphoserine
Seqacetylation
    2-2 N-acetylalanine
    856-856 N6-acetyllysine
    1441-1441 N6-acetyllysine; alternate
    1501-1501 N6-acetyllysine
 
Prediction
NeProc
Disorder 1-3,1616-1675
Order 4-538,543-1615
ProS 1616-1620,1637-1644,1669-1675
AlphaFold
Disorder 1-3,388-388,406-411,539-542,837-838,887-892,895-897,910-920,922-922,924-931,934-945,947-949,951-951,953-953,955-955,957-960,962-967,970-970,974-989,992-993,996-996,998-1005,1008-1025,1028-1050,1052-1054,1056-1062,1064-1071,1073-1090,1092-1096,1098-1106,1117-1117,1131-1135,1145-1146,1148-1148,1163-1165,1193-1193,1196-1196,1623-1675
Order 4-387,389-405,412-538,543-836,839-886,893-894,898-909,921-921,923-923,932-933,946-946,950-950,952-952,954-954,956-956,961-961,968-969,971-973,990-991,994-995,997-997,1006-1007,1026-1027,1051-1051,1055-1055,1063-1063,1072-1072,1091-1091,1097-1097,1107-1116,1118-1130,1136-1144,1147-1147,1149-1162,1166-1192,1194-1195,1197-1622
Pfam Hmmer
PF01394 19-56 0.00038
PF01394 60-94 0.00025
PF01394 102-133 0.00029
PF01394 198-234 1.3e-05
PF00637 537-679 2.5e-40
PF00637 686-828 1.2e-50
PF00637 833-972 7e-48
PF00637 979-1124 2.3e-51
PF00637 1128-1269 3.7e-53
PF00637 1274-1420 5.1e-53
PF00637 1423-1566 1.3e-41
SEG 445-458 ,1662-1673
Function
Function in SwissProt
Clathrin is the major protein of the polyhedral coat of coated pits and vesicles. Two different adapter protein complexes link the clathrin lattice either to the plasma membrane or to the trans-Golgi network. Acts as component of the TACC3/ch-TOG/clathrin complex proposed to contribute to stabilization of kinetochore fibers of the mitotic spindle by acting as inter-microtubule bridge (PubMed:15858577, PubMed:16968737, PubMed:21297582). The TACC3/ch-TOG/clathrin complex is required for the maintenance of kinetochore fiber tension (PubMed:23532825). Plays a role in early autophagosome formation (PubMed:20639872).