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IID00663
 UniprotQ08999
ProteinRetinoblastoma-like protein 2
GeneRBL2
OrganismHomo sapiens
Sequence LLPS PhaSepDB
PhaSePro
LLPSDB
DrLLPS
 Network xml rdf
Structure
Experiment
  :order   disorder   conflict   PDB cluster   ProS   Pfam Domain   SEG
1139
 order/disorder by at least rule
     disorder by at least rule
     order by at least rule
 order/disorder by majority rule
Seq 416-422 Hetero dimer : O15294
 Evidence X-RAY 5c1d C Reference
       Region 5c1d C 416-422 order
Seq 416-422 Hetero octamer : O15294
 Evidence X-RAY 4xi9 E Reference
       Region 4xi9 E 416-422 order
 Evidence X-RAY 4xi9 F Reference
       Region 4xi9 F 416-422 order
 Evidence X-RAY 4xi9 G Reference
       Region 4xi9 G 416-422 order
 Evidence X-RAY 4xi9 H Reference
       Region 4xi9 H 416-422 order
Seqphosphorylation
    1035-1035 Phosphoserine
    1068-1068 Phosphoserine
    1080-1080 Phosphoserine
    1112-1112 Phosphoserine
    986-986 Phosphothreonine
    982-982 Phosphoserine
    981-981 Phosphoserine
    974-974 Phosphothreonine
    973-973 Phosphoserine
    972-972 Phosphoserine
    971-971 Phosphoserine
    966-966 Phosphoserine
    952-952 Phosphoserine
    948-948 Phosphoserine
    688-688 Phosphoserine
    672-672 Phosphoserine
    662-662 Phosphoserine
    642-642 Phosphothreonine
    639-639 Phosphoserine
    417-417 Phosphothreonine
    413-413 Phosphoserine
 
Prediction
NeProc
Disorder 1-42,180-190,364-420,626-828,942-1000,1009-1017,1028-1072,1084-1088,1095-1139
Order 43-179,191-363,421-625,829-941,1001-1008,1018-1027,1073-1083,1089-1094
ProS 4-8,187-190,364-371,378-383,405-420,626-643,654-661,681-685,729-736,750-763,788-793,942-989,1009-1017,1049-1060,1084-1088,1102-1105,1116-1136
AlphaFold
Disorder 1-41,97-111,177-193,217-217,244-247,256-271,346-346,364-416,475-484,547-547,630-667,671-833,936-999,1027-1029,1040-1054,1059-1071,1096-1139
Order 42-96,112-176,194-216,218-243,248-255,272-345,347-363,417-474,485-546,548-629,668-670,834-935,1000-1026,1030-1039,1055-1058,1072-1095
Pfam Hmmer
PF01858 417-609 3.3e-123
PF01857 834-992 9.8e-107
SEG 2-41 ,177-194 ,304-316 ,726-737 ,762-773 ,780-793 ,808-827 ,962-973 ,976-988
Function
Function in SwissProt
Key regulator of entry into cell division. Directly involved in heterochromatin formation by maintaining overall chromatin structure and, in particular, that of constitutive heterochromatin by stabilizing histone methylation. Recruits and targets histone methyltransferases KMT5B and KMT5C, leading to epigenetic transcriptional repression. Controls histone H4 'Lys-20' trimethylation. Probably acts as a transcription repressor by recruiting chromatin-modifying enzymes to promoters. Potent inhibitor of E2F-mediated trans-activation, associates preferentially with E2F5. Binds to cyclins A and E. Binds to and may be involved in the transforming capacity of the adenovirus E1A protein. May act as a tumor suppressor.