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IID00664
 UniprotQ12879
ProteinGlutamate receptor ionotropic, NMDA 2A
GeneGRIN2A
OrganismHomo sapiens
Sequence LLPS PhaSepDB
PhaSePro
LLPSDB
DrLLPS Network xml rdf
Structure
Experiment
  :order   disorder   conflict   PDB cluster   ProS   Pfam Domain   SEG
1464
 order/disorder by at least rule
     disorder by at least rule
     order by at least rule
 order/disorder by majority rule
Seq 401-539,661-802 Hetero dimer : Q05586
 Evidence X-RAY 5tp9 A Reference
       Region 5tp9 A 401-403 disorder
       Region 5tp9 A 404-423 order
       Region 5tp9 A 424-426 disorder
       Region 5tp9 A 427-539 order
       Region 5tp9 A 661-800 order
       Region 5tp9 A 801-802 disorder
Seq 401-539,661-802 Hetero dimer : Q05586
 Evidence X-RAY 5tpa A Reference
       Region 5tpa A 401-403 disorder
       Region 5tpa A 404-423 order
       Region 5tpa A 424-426 disorder
       Region 5tpa A 427-539 order
       Region 5tpa A 661-800 order
       Region 5tpa A 801-802 disorder
Seq 401-539,661-802 Hetero dimer : Q05586
 Evidence X-RAY 5h8n A Reference
       Region 5h8n A 401-403 disorder
       Region 5h8n A 404-424 order
       Region 5h8n A 425-426 disorder
       Region 5h8n A 427-539 order
       Region 5h8n A 661-800 order
       Region 5h8n A 801-802 disorder
Seq 401-539,661-802 Hetero dimer : Q05586
 Evidence X-RAY 5kcj A Reference
       Region 5kcj A 401-402 disorder
       Region 5kcj A 403-539 order
       Region 5kcj A 661-800 order
       Region 5kcj A 801-802 disorder
Seq 401-539,661-802 Hetero dimer : Q05586
 Evidence X-RAY 5h8q A Reference
       Region 5h8q A 401-403 disorder
       Region 5h8q A 404-424 order
       Region 5h8q A 425-426 disorder
       Region 5h8q A 427-539 order
       Region 5h8q A 661-800 order
       Region 5h8q A 801-802 disorder
Seq 401-539,661-802 Hetero dimer : Q05586
 Evidence X-RAY 5h8f A Reference
       Region 5h8f A 401-403 disorder
       Region 5h8f A 404-422 order
       Region 5h8f A 423-426 disorder
       Region 5h8f A 427-539 order
       Region 5h8f A 661-800 order
       Region 5h8f A 801-802 disorder
Seq 401-539,661-802 Hetero dimer : Q05586
 Evidence X-RAY 5i2n A Reference
       Region 5i2n A 401-402 disorder
       Region 5i2n A 403-424 order
       Region 5i2n A 425-426 disorder
       Region 5i2n A 427-539 order
       Region 5i2n A 661-800 order
       Region 5i2n A 801-802 disorder
Seq 401-539,661-802 Hetero dimer : Q05586
 Evidence X-RAY 5i2k A Reference
       Region 5i2k A 401-403 disorder
       Region 5i2k A 404-424 order
       Region 5i2k A 425-426 disorder
       Region 5i2k A 427-539 order
       Region 5i2k A 661-800 order
       Region 5i2k A 801-802 disorder
Seq 401-539,661-802 Hetero dimer : Q05586
 Evidence X-RAY 5h8h A Reference
       Region 5h8h A 401-402 disorder
       Region 5h8h A 403-424 order
       Region 5h8h A 425-426 disorder
       Region 5h8h A 427-539 order
       Region 5h8h A 661-800 order
       Region 5h8h A 801-802 disorder
Seq 401-539,661-802 Hetero dimer : Q05586
 Evidence X-RAY 5kdt A Reference
       Region 5kdt A 401-402 disorder
       Region 5kdt A 403-424 order
       Region 5kdt A 425-426 disorder
       Region 5kdt A 427-539 order
       Region 5kdt A 661-801 order
       Region 5kdt A 802-802 disorder
Seq 1449-1464 Hetero dimer : IID00656Complex
 Evidence X-RAY 3nfl H Reference
       Region 3nfl H 1449-1459 disorder
       Region 3nfl H 1460-1464 order
 Evidence X-RAY 3nfl G Reference
       Region 3nfl G 1449-1459 disorder
       Region 3nfl G 1460-1464 order
 Evidence X-RAY 3nfl F Reference
       Region 3nfl F 1449-1459 disorder
       Region 3nfl F 1460-1464 order
 Evidence X-RAY 3nfl E Reference
       Region 3nfl E 1449-1459 disorder
       Region 3nfl E 1460-1464 order
Seqphosphorylation
    882-882 Phosphoserine
    890-890 Phosphoserine
    929-929 Phosphoserine
    1025-1025 Phosphoserine
    1059-1059 Phosphoserine
    1062-1062 Phosphoserine
    1198-1198 Phosphoserine
    1291-1291 Phosphoserine
 
Prediction
NeProc
Disorder 1-30,323-326,630-632,803-812,875-1353,1391-1464
Order 31-42,48-322,327-393,398-539,548-629,633-802,813-874,1354-1390
ProS 1-25,323-326,630-632,803-810,895-901,921-926,954-960,969-980,995-1003,1011-1019,1039-1063,1095-1104,1115-1131,1136-1225,1232-1256,1281-1301,1307-1331,1339-1353,1395-1405,1412-1464
AlphaFold
Disorder 1-31,43-45,56-62,210-212,251-251,315-318,322-333,388-404,442-449,540-544,580-599,655-661,751-753,801-813,845-1464
Order 32-42,46-55,63-209,213-250,252-314,319-321,334-387,405-441,450-539,545-579,600-654,662-750,754-800,814-844
Pfam Hmmer
PF00060 554-838 3.6e-110
SEG 900-917 ,1333-1343
Function
Function in SwissProt
Component of NMDA receptor complexes that function as heterotetrameric, ligand-gated ion channels with high calcium permeability and voltage-dependent sensitivity to magnesium. Channel activation requires binding of the neurotransmitter glutamate to the epsilon subunit, glycine binding to the zeta subunit, plus membrane depolarization to eliminate channel inhibition by Mg(2+) (PubMed:8768735, PubMed:26919761, PubMed:26875626, PubMed:28105280). Sensitivity to glutamate and channel kinetics depend on the subunit composition; channels containing GRIN1 and GRIN2A have lower sensitivity to glutamate and faster deactivation kinetics than channels formed by GRIN1 and GRIN2B (PubMed:26919761, PubMed:26875626). Contributes to the slow phase of excitatory postsynaptic current, long-term synaptic potentiation, and learning (By similarity).