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IID00665
UniprotQ12913
ProteinReceptor-type tyrosine-protein phosphatase eta
GenePTPRJ
OrganismHomo sapiens
Sequence LLPS PhaSepDB
PhaSePro
LLPSDB
DrLLPS
xml
Structure
Experiment
  :order   disorder   conflict   PDB cluster   ProS   Pfam Domain   SEG
1337
 order/disorder by at least rule
     disorder by at least rule
     order by at least rule
 order/disorder by majority rule
Seq 366-456 Monomer :
 Evidence NMR 2dle A Reference
       Region 2dle A 366-456 order
Seq 1019-1311 Monomer :
 Evidence X-RAY 2cfv A Reference
       Region 2cfv A 1019-1139 order
       Region 2cfv A 1140-1150 disorder
       Region 2cfv A 1151-1155 order
       Region 2cfv A 1156-1157 disorder
       Region 2cfv A 1158-1174 order
       Region 2cfv A 1175-1176 disorder
       Region 2cfv A 1177-1188 order
       Region 2cfv A 1189-1190 disorder
       Region 2cfv A 1191-1201 order
       Region 2cfv A 1202-1210 disorder
       Region 2cfv A 1211-1225 order
       Region 2cfv A 1226-1233 disorder
       Region 2cfv A 1234-1300 order
       Region 2cfv A 1301-1311 disorder
 Evidence X-RAY 2nz6 A Reference
       Region 2nz6 A 1019-1140 order
       Region 2nz6 A 1141-1150 disorder
       Region 2nz6 A 1151-1226 order
       Region 2nz6 A 1227-1231 disorder
       Region 2nz6 A 1232-1303 order
       Region 2nz6 A 1304-1307 disorder
       Region 2nz6 A 1308-1311 order
Seqphosphorylation
    1009-1009 Phosphoserine
 
Prediction
NeProc
Disorder 1-9,284-302,963-973,997-1015
Order 10-278,303-705,710-962,974-996,1016-1302,1307-1337
ProS 1-9,284-290,298-302,963-973,997-1000,1011-1015
AlphaFold
Disorder 1-120,143-147,156-160,190-194,244-254,275-325,391-395,490-493,565-567,666-669,703-703,769-773,890-903,944-945,970-1016,1205-1206,1304-1337
Order 121-142,148-155,161-189,195-243,255-274,326-390,396-489,494-564,568-665,670-702,704-768,774-889,904-943,946-969,1017-1204,1207-1303
Pfam Hmmer
PF00041 119-199 1.4e-05
PF00041 540-615 2.5e-05
PF00041 626-710 0.00028
PF00102 1065-1297 2.1e-124
SEG 15-31 ,808-827
Function
Function in SwissProt
Tyrosine phosphatase which dephosphorylates or contributes to the dephosphorylation of CTNND1, FLT3, PDGFRB, MET, RET (variant MEN2A), KDR, LYN, SRC, MAPK1, MAPK3, EGFR, TJP1, OCLN, PIK3R1 and PIK3R2. Plays a role in cell adhesion, migration, proliferation and differentiation. Involved in vascular development. Regulator of macrophage adhesion and spreading. Positively affects cell-matrix adhesion. Positive regulator of platelet activation and thrombosis. Negative regulator of cell proliferation. Negative regulator of PDGF-stimulated cell migration; through dephosphorylation of PDGFR. Positive regulator of endothelial cell survival, as well as of VEGF-induced SRC and AKT activation; through KDR dephosphorylation. Negative regulator of EGFR signaling pathway; through EGFR dephosphorylation. Enhances the barrier function of epithelial junctions during reassembly. Negatively regulates T-cell receptor (TCR) signaling. Upon T-cell TCR activation, it is up-regulated and excluded from the immunological synapses, while upon T-cell-antigen presenting cells (APC) disengagement, it is no longer excluded and can dephosphorylate PLCG1 and LAT to down-regulate prolongation of signaling.
Biological Process
See also
Diagram with PDB data
SRCCRYSTAL STRUCTURE OF HUMAN TYROSINE-PROTEIN KINASE C-SRC, IN COMPLEX WITH AMP-PNP