IDEAL List

IDEAL

IID00667
UniprotQ13342
ProteinNuclear body protein SP140
GeneSP140
OrganismHomo sapiens
Sequence LLPS PhaSepDB
PhaSePro
LLPSDB
DrLLPS
xml

Structure

Experiment

:order disorder conflict PDB cluster ProS Pfam Domain SEG

867

order/disorder by at least rule

disorder by at least rule

order by at least rule

order/disorder by majority rule

Seq 687-738 Monomer :

Evidence NMR 2md8 C Reference

Region 2md8 C 687-738 order

Region 2md8 C 687-688 high_rmsd

Region 2md8 C 722-724 high_rmsd

Region 2md8 C 736-738 high_rmsd

Evidence NMR 2md7 B Reference

Region 2md7 B 687-738 order

Region 2md7 B 687-687 high_rmsd

Region 2md7 B 723-724 high_rmsd

Region 2md7 B 736-738 high_rmsd

Seqphosphorylation

726-726 Phosphothreonine

Prediction

NeProc

Disorder 1-31,145-600,634-652,660-686,744-751,863-867

Order 32-144,601-633,653-659,687-743,752-862

ProS 4-31,145-153,195-200,207-213,221-240,253-261,294-304,310-380,386-400,411-420,451-462,477-491,550-560,568-571,577-600,634-652,660-686,744-751,863-867

AlphaFold

Disorder 1-39,138-581,664-690,739-744,784-784,787-795,834-840,863-867

Order 40-137,582-663,691-738,745-783,785-786,796-833,841-862

Pfam Hmmer

PF03172 36-139 1.1e-76

PF01342 580-661 3.1e-54

PF00628 692-736 4.4e-09

PF00439 756-845 3.5e-14

SEG 1-11 ,310-327 ,371-388 ,404-416 ,425-437 ,496-503 ,665-676

Function

Function in SwissProt

Component of the nuclear body, also known as nuclear domain 10, PML oncogenic domain, and KR body (PubMed:8910577). May be involved in the pathogenesis of acute promyelocytic leukemia and viral infection (PubMed:8910577). May play a role in chromatin-mediated regulation of gene expression although it does not bind to histone H3 tails (PubMed:24267382).