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IID00668
UniprotQ14444
ProteinCaprin-1
GeneCAPRIN1
OrganismHomo sapiens
Sequence LLPS PhaSepDB
PhaSePro
LLPSDB
DrLLPS
xml
Structure
Experiment
  :order   disorder   conflict   PDB cluster   ProS   Pfam Domain   SEG
709
 order/disorder by at least rule
     disorder by at least rule
     order by at least rule
 order/disorder by majority rule
Seq 132-251 Homo dimer :
 Evidence X-RAY 4wbp B Reference
       Region 4wbp B 132-250 order
       Region 4wbp B 251-251 disorder
 Evidence X-RAY 4wbp A Reference
       Region 4wbp A 132-251 order
 Evidence X-RAY 4wbe C Reference
       Region 4wbe C 132-132 disorder
       Region 4wbe C 133-251 order
 Evidence X-RAY 4wbe B Reference
       Region 4wbe B 132-251 order
 Evidence X-RAY 4wbe A Reference
       Region 4wbe A 132-251 order
Seqphosphorylation
    625-625 Phosphotyrosine; by EPHA4
    665-665 Phosphotyrosine; by EPHA4
    662-662 Phosphotyrosine; by EPHA4
    651-651 Phosphotyrosine; by EPHA4
    639-639 Phosphotyrosine; by EPHA4
    636-636 Phosphotyrosine; by EPHA4
    670-670 Phosphotyrosine; by EPHA4
    343-343 Phosphoserine
    335-335 Phosphoserine
    115-115 Phosphoserine
    10-10 Phosphoserine
Seqacetylation
    2-2 N-acetylproline
 
Prediction
NeProc
Disorder 1-49,252-709
Order 50-251
ProS 369-374,422-426,519-525,595-624,630-651,658-676,682-688,697-709
AlphaFold
Disorder 1-18,20-46,249-351,367-709
Order 19-19,47-248,352-366
SEG 2-43 ,63-75 ,178-188 ,258-282 ,311-324 ,328-337 ,477-491 ,537-552 ,555-570 ,607-620 ,676-704
Function
Function in SwissProt
May regulate the transport and translation of mRNAs of proteins involved in synaptic plasticity in neurons and cell proliferation and migration in multiple cell types. Binds directly and selectively to MYC and CCND2 RNAs. In neuronal cells, directly binds to several mRNAs associated with RNA granules, including BDNF, CAMK2A, CREB1, MAP2, NTRK2 mRNAs, as well as to GRIN1 and KPNB1 mRNAs, but not to rRNAs.