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IID00670
 UniprotQ14781
ProteinChromobox protein homolog 2
GeneCBX2
OrganismHomo sapiens
Sequence LLPS PhaSepDB
PhaSePro
LLPSDB
DrLLPS Network xml rdf
Structure
Experiment
  :order   disorder   conflict   PDB cluster   ProS   Pfam Domain   SEG
532
 order/disorder by at least rule
     disorder by at least rule
     order by at least rule
 order/disorder by majority rule
Seq 8-69 Monomer :
 Evidence X-RAY 5epk A Reference
       Region 5epk A 8-8 disorder
       Region 5epk A 9-62 order
 Evidence NMR 2d9u A Reference
       Region 2d9u A 9-69 order
       Region 2d9u A 9-10 high_rmsd
       Region 2d9u A 68-69 high_rmsd
Seq 9-62 Hetero tetramer : Q92133
 Evidence X-RAY 3h91 B Reference
       Region 3h91 B 9-60 order
       Region 3h91 B 61-62 disorder
 Evidence X-RAY 3h91 A Reference
       Region 3h91 A 9-60 order
       Region 3h91 A 61-62 disorder
Seqphosphorylation
    302-302 Phosphoserine
 
Prediction
NeProc
Disorder 1-6,62-491
Order 7-61,492-532
ProS 90-104,122-131,138-155,182-186,428-432
AlphaFold
Disorder 1-9,73-253,269-500,522-532
Order 10-72,254-268,501-521
Pfam Hmmer
PF00385 12-61 6.2e-19
SEG 70-82 ,102-127 ,195-209 ,265-280 ,464-478
Function
Function in SwissProt
Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development (PubMed:21282530). PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility (PubMed:21282530). Binds to histone H3 trimethylated at 'Lys-9' (H3K9me3) or at 'Lys-27' (H3K27me3) (By similarity). Plays a role in the lineage differentiation of the germ layers in embryonic development (By similarity). Involved in sexual development, acting as activator of NR5A1 expression (PubMed:19361780).