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IID00671
 UniprotQ16186
ProteinProteasomal ubiquitin receptor ADRM1
GeneADRM1
OrganismHomo sapiens
Sequence LLPS PhaSepDB
PhaSePro
LLPSDB
DrLLPS Network xml rdf
Structure
Experiment
  :order   disorder   conflict   PDB cluster   ProS   Pfam Domain   SEG
407
 order/disorder by at least rule
     disorder by at least rule
     order by at least rule
 order/disorder by majority rule
Seq 1-150 Hetero dimer : Q9UHD9
 Evidence NMR 2nbv A Reference
       Region 2nbv A 1-20 disorder
       Region 2nbv A 21-130 order
       Region 2nbv A 131-150 disorder
Seq 1-407 Monomer :
 Evidence NMR 2kr0 A Reference
       Region 2kr0 A 1-407 order
       Region 2kr0 A 1-20 high_rmsd
       Region 2kr0 A 135-258 high_rmsd
       Region 2kr0 A 281-281 high_rmsd
       Region 2kr0 A 389-407 high_rmsd
Seq 2-150 Monomer :
 Evidence X-RAY 5irs A Reference
       Region 5irs A 2-20 disorder
       Region 5irs A 21-130 order
       Region 5irs A 131-150 disorder
Seq 19-132 Hetero trimer : P0CG47,Q99460
 Evidence X-RAY 5v1z B Reference
       Region 5v1z B 19-20 disorder
       Region 5v1z B 21-132 order
 Evidence X-RAY 5v1z A Reference
       Region 5v1z A 19-19 disorder
       Region 5v1z A 20-131 order
       Region 5v1z A 132-132 disorder
 Evidence X-RAY 5v1y B Reference
       Region 5v1y B 19-19 disorder
       Region 5v1y B 20-132 order
 Evidence X-RAY 5v1y A Reference
       Region 5v1y A 19-131 order
       Region 5v1y A 132-132 disorder
Seq 253-407 Monomer :
 Evidence NMR 2mkz A Reference
       Region 2mkz A 270-407 order
       Region 2mkz A 270-284 high_rmsd
       Region 2mkz A 387-407 high_rmsd
 Evidence NMR 2l5v A Reference
       Region 2l5v A 260-407 order
       Region 2l5v A 260-285 high_rmsd
       Region 2l5v A 387-407 high_rmsd
 Evidence NMR 2kqz A Reference
       Region 2kqz A 253-407 order
       Region 2kqz A 253-284 high_rmsd
       Region 2kqz A 389-407 high_rmsd
Seq 266-388 Hetero dimer : Q9Y5K5
 Evidence X-RAY 4uem B Reference
       Region 4uem B 266-286 disorder
       Region 4uem B 287-384 order
       Region 4uem B 385-388 disorder
Seq 266-388 Hetero trimer : P0CG47,Q9Y5K5
 Evidence X-RAY 4uel C Reference
       Region 4uel C 266-286 disorder
       Region 4uel C 287-384 order
       Region 4uel C 385-388 disorder
Seq 285-386 Hetero trimer : P0CG47,Q9WUP7
 Evidence X-RAY 4wlr B Reference
       Region 4wlr B 285-285 disorder
       Region 4wlr B 286-384 order
       Region 4wlr B 385-386 disorder
Seq 286-384 Hetero dimer : Q9WUP7
 Evidence X-RAY 4wlq B Reference
       Region 4wlq B 286-384 order
Seqphosphorylation
    15-15 Phosphoserine
    127-127 Phosphotyrosine
    140-140 Phosphoserine
    211-211 Phosphoserine
    217-217 Phosphothreonine
    405-405 Phosphoserine
Seqacetylation
    2-2 N-acetylthreonine
 
Prediction
NeProc
Disorder 1-20,135-325,384-407
Order 21-134,326-383
ProS 163-171,218-238,251-255,261-274,284-308,404-407
AlphaFold
Disorder 1-20,132-162,164-168,170-264,266-345,347-347,350-360,381-382,384-407
Order 21-131,163-163,169-169,265-265,346-346,348-349,361-380,383-383
Pfam Hmmer
PF04683 21-392 1.8e-240
SEG 135-161 ,173-259 ,390-403
Function
Function in SwissProt
Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair. Within the complex, functions as a proteasomal ubiquitin receptor. Engages and activates 19S-associated deubiquitinases UCHL5 and PSMD14 during protein degradation. UCHL5 reversibly associate with the 19S regulatory particle whereas PSMD14 is an intrinsic subunit of the proteasome lid subcomplex.