Search Keyword:


Search option:


IID00673
 UniprotQ63HR2
ProteinTensin-2
GeneTNS2
OrganismHomo sapiens
Sequence LLPS PhaSepDB
PhaSePro
LLPSDB
DrLLPS
 Network xml rdf
Structure
Experiment
  :order   disorder   conflict   PDB cluster   ProS   Pfam Domain   SEG
1409
 order/disorder by at least rule
     disorder by at least rule
     order by at least rule
 order/disorder by majority rule
Seq 1135-1249 Monomer :
 Evidence NMR 2l6k A Reference
       Region 2l6k A 1135-1248 order
       Region 2l6k A 1185-1193 high_rmsd
       Region 2l6k A 1247-1248 high_rmsd
 Evidence NMR 2kno A Reference
       Region 2kno A 1135-1249 order
       Region 2kno A 1248-1249 high_rmsd
Seq 1263-1409 Monomer :
 Evidence NMR 2dkq A Reference
       Region 2dkq A 1263-1409 order
       Region 2dkq A 1263-1264 high_rmsd
       Region 2dkq A 1407-1409 high_rmsd
 Evidence X-RAY 3hqc A Reference
       Region 3hqc A 1264-1306 order
       Region 3hqc A 1307-1309 disorder
       Region 3hqc A 1310-1406 order
       Region 3hqc A 1407-1409 disorder
Seq 1263-1409 Hetero dimer : IID00677Complex
 Evidence NMR 2loz A Reference
       Region 2loz A 1263-1409 order
       Region 2loz A 1263-1264 high_rmsd
Seqphosphorylation
    483-483 Phosphotyrosine
    941-941 Phosphoserine
    931-931 Phosphoserine
    910-910 Phosphothreonine
    845-845 Phosphoserine
    835-835 Phosphoserine
    832-832 Phosphoserine
    830-830 Phosphoserine
    825-825 Phosphoserine
    820-820 Phosphoserine
    977-977 Phosphothreonine
    481-481 Phosphoserine
    474-474 Phosphothreonine
    466-466 Phosphoserine
    456-456 Phosphotyrosine
    455-455 Phosphoserine
    120-120 Phosphoserine
    118-118 Phosphoserine
    91-91 Phosphothreonine
    972-972 Phosphoserine
    1247-1247 Phosphoserine
    1182-1182 Phosphothreonine
    1003-1003 Phosphoserine
    991-991 Phosphoserine
 
Prediction
NeProc
Disorder 1-34,76-125,476-1137,1159-1164,1183-1195,1252-1267,1405-1409
Order 35-75,126-475,1138-1158,1165-1182,1196-1251,1268-1371,1377-1404
ProS 6-14,31-34,96-103,476-488,538-552,559-566,593-600,614-621,645-654,689-695,705-710,768-775,849-857,881-886,910-915,1029-1034,1057-1066,1128-1137,1159-1164
AlphaFold
Disorder 1-29,82-129,148-149,253-256,317-318,344-347,375-375,430-433,454-455,457-457,467-533,535-1132,1184-1192,1250-1273,1376-1376,1405-1409
Order 30-81,130-147,150-252,257-316,319-343,348-374,376-429,434-453,456-456,458-466,534-534,1133-1183,1193-1249,1274-1375,1377-1404
Pfam Hmmer
PF00130 32-82 1.2e-05
PF00017 1140-1232 4.9e-10
PF08416 1239-1408 4.3e-130
SEG 9-27 ,489-513 ,546-559 ,968-987 ,1019-1031 ,1080-1091 ,1116-1128
Function
Function in SwissProt
Tyrosine-protein phosphatase which regulates cell motility proliferation and muscle-response to insulin (PubMed:15817639, PubMed:23401856). In muscles and under catabolic conditions, dephosphorylates IRS1 leading to its degradation and muscle atrophy (PubMed:23401856). Negatively regulates PI3K-AKT pathway activation (PubMed:15817639, PubMed:23401856).