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IID00674
 UniprotQ8N3U4
ProteinCohesin subunit SA-2
GeneSTAG2
OrganismHomo sapiens
Sequence LLPS PhaSepDB
PhaSePro
LLPSDB
DrLLPS Network xml rdf
Structure
Experiment
  :order   disorder   conflict   PDB cluster   ProS   Pfam Domain   SEG
1231
 order/disorder by at least rule
     disorder by at least rule
     order by at least rule
 order/disorder by majority rule
Seq 80-1060 Hetero dimer : IID00642Complex
 Evidence X-RAY 4pk7 A Reference
       Region 4pk7 A 80-82 disorder
       Region 4pk7 A 83-254 order
       Region 4pk7 A 255-260 disorder
       Region 4pk7 A 261-438 order
       Region 4pk7 A 439-454 disorder
       Region 4pk7 A 455-505 order
       Region 4pk7 A 506-511 disorder
       Region 4pk7 A 512-543 order
       Region 4pk7 A 544-546 disorder
       Region 4pk7 A 547-748 order
       Region 4pk7 A 749-751 disorder
       Region 4pk7 A 752-804 order
       Region 4pk7 A 805-805 disorder
       Region 4pk7 A 806-836 order
       Region 4pk7 A 837-852 disorder
       Region 4pk7 A 853-933 order
       Region 4pk7 A 934-935 disorder
       Region 4pk7 A 936-959 order
       Region 4pk7 A 960-964 disorder
       Region 4pk7 A 965-986 order
       Region 4pk7 A 987-987 disorder
       Region 4pk7 A 988-990 order
       Region 4pk7 A 991-992 disorder
       Region 4pk7 A 993-1035 order
       Region 4pk7 A 1036-1036 disorder
       Region 4pk7 A 1037-1047 order
       Region 4pk7 A 1048-1060 disorder
 Evidence X-RAY 4pjw A Reference
       Region 4pjw A 80-82 disorder
       Region 4pjw A 83-91 order
       Region 4pjw A 92-92 disorder
       Region 4pjw A 93-254 order
       Region 4pjw A 255-259 disorder
       Region 4pjw A 260-438 order
       Region 4pjw A 439-454 disorder
       Region 4pjw A 455-505 order
       Region 4pjw A 506-512 disorder
       Region 4pjw A 513-543 order
       Region 4pjw A 544-547 disorder
       Region 4pjw A 548-748 order
       Region 4pjw A 749-752 disorder
       Region 4pjw A 753-836 order
       Region 4pjw A 837-852 disorder
       Region 4pjw A 853-959 order
       Region 4pjw A 960-964 disorder
       Region 4pjw A 965-991 order
       Region 4pjw A 992-993 disorder
       Region 4pjw A 994-1035 order
       Region 4pjw A 1036-1036 disorder
       Region 4pjw A 1037-1048 order
       Region 4pjw A 1049-1060 disorder
 Evidence X-RAY 4pju A Reference
       Region 4pju A 80-82 disorder
       Region 4pju A 83-253 order
       Region 4pju A 254-260 disorder
       Region 4pju A 261-438 order
       Region 4pju A 439-455 disorder
       Region 4pju A 456-505 order
       Region 4pju A 506-512 disorder
       Region 4pju A 513-543 order
       Region 4pju A 544-545 disorder
       Region 4pju A 546-674 order
       Region 4pju A 675-676 disorder
       Region 4pju A 677-748 order
       Region 4pju A 749-752 disorder
       Region 4pju A 753-804 order
       Region 4pju A 805-807 disorder
       Region 4pju A 808-836 order
       Region 4pju A 837-851 disorder
       Region 4pju A 852-932 order
       Region 4pju A 933-937 disorder
       Region 4pju A 938-959 order
       Region 4pju A 960-965 disorder
       Region 4pju A 966-986 order
       Region 4pju A 987-987 disorder
       Region 4pju A 988-990 order
       Region 4pju A 991-992 disorder
       Region 4pju A 993-1049 order
       Region 4pju A 1050-1060 disorder
Seqphosphorylation
    1058-1058 Phosphoserine
    1061-1061 Phosphoserine
    1064-1064 Phosphoserine
    1065-1065 Phosphoserine
    1112-1112 Phosphothreonine
    1177-1177 Phosphoserine
    1178-1178 Phosphoserine
Seqacetylation
    1-1 N-acetylmethionine
    607-607 N6-acetyllysine
 
Prediction
NeProc
Disorder 1-79,445-455,751-754,840-852,989-992,1054-1231
Order 80-444,456-470,476-505,512-750,755-839,853-988,993-1053
ProS 2-11,450-455,840-852,989-992,1054-1059,1154-1158,1183-1231
AlphaFold
Disorder 1-81,439-451,544-545,752-752,837-850,852-852,1050-1231
Order 82-438,452-543,546-751,753-836,851-851,853-1049
Pfam Hmmer
PF08514 154-273 2e-73
SEG 32-62 ,262-276 ,300-314 ,501-513 ,1090-1107
Function
Function in SwissProt
Component of cohesin complex, a complex required for the cohesion of sister chromatids after DNA replication. The cohesin complex apparently forms a large proteinaceous ring within which sister chromatids can be trapped. At anaphase, the complex is cleaved and dissociates from chromatin, allowing sister chromatids to segregate. The cohesin complex may also play a role in spindle pole assembly during mitosis.