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IID00677
 UniprotQ96QB1
ProteinRho GTPase-activating protein 7
GeneDLC1
OrganismHomo sapiens
Sequence LLPS PhaSepDB
PhaSePro
LLPSDB
DrLLPS
 Network xml rdf
Structure
Experiment
  :order   disorder   conflict   PDB cluster   ProS   Pfam Domain   SEG
1528
 order/disorder by at least rule
     disorder by at least rule
     order by at least rule
 order/disorder by majority rule
Seq 451-515 Monomer :
 Evidence NMR 2dky A Reference
       Region 2dky A 451-515 order
 Evidence NMR 2gyt A Reference
       Region 2gyt A 451-513 order
 Evidence NMR 2kap A Reference
       Region 2kap A 454-513 order
Seq 811-824 Hetero dimer : IID00673Complex
 Evidence NMR 2loz B Reference
       Region 2loz B 811-824 order
       Region 2loz B 811-811 high_rmsd
       Region 2loz B 824-824 high_rmsd
Seq 904-926 Hetero dimer : IID50205Complex
 Evidence 5fzt B Reference
       Region 5fzt B 904-926 order
Seqdisorder 904-926
 Evidence Reference
       Region 904-926 disorder
Seq 1074-1283 Monomer :
 Evidence X-RAY 3kuq A Reference
       Region 3kuq A 1074-1239 order
       Region 3kuq A 1240-1258 disorder
       Region 3kuq A 1259-1279 order
       Region 3kuq A 1280-1283 disorder
Seqphosphorylation
    523-523 Phosphoserine
    526-526 Phosphoserine
    566-566 Phosphoserine
    757-757 Phosphoserine
 
Prediction
NeProc
Disorder 1-6,59-220,240-436,522-804,809-1008,1239-1253,1297-1315,1520-1528
Order 7-58,221-239,437-517,805-808,1009-1238,1254-1296,1316-1519
ProS 1-6,59-87,95-174,180-220,240-264,274-279,287-309,317-345,351-375,387-392,431-436,527-555,573-594,664-676,691-723,767-781,788-804,809-852,871-885,892-896,902-931,950-956,963-970,980-985,993-1008,1297-1315,1520-1528
AlphaFold
Disorder 1-348,373-443,513-531,551-816,818-818,820-906,923-923,926-1017,1048-1069,1071-1072,1132-1134,1237-1258,1289-1296,1298-1299,1311-1319,1339-1341,1517-1528
Order 349-372,444-512,532-550,817-817,819-819,907-922,924-925,1018-1047,1070-1070,1073-1131,1135-1236,1259-1288,1297-1297,1300-1310,1320-1338,1342-1516
Pfam Hmmer
PF07647 448-515 1.2e-09
PF00620 1092-1238 5.6e-56
PF01852 1323-1522 2.9e-71
SEG 336-351 ,374-384 ,445-456 ,586-605 ,673-690 ,733-760 ,824-837 ,865-877 ,973-982
Function
Function in SwissProt
Functions as a GTPase-activating protein for the small GTPases RHOA, RHOB, RHOC and CDC42, terminating their downstream signaling. This induces morphological changes and detachment through cytoskeletal reorganization, playing a critical role in biological processes such as cell migration and proliferation. Also functions in vivo as an activator of the phospholipase PLCD1. Active DLC1 increases cell migration velocity but reduces directionality.