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IID00679
 UniprotQ9BUB5
ProteinMAP kinase-interacting serine/threonine-protein kinase 1
GeneMKNK1
OrganismHomo sapiens
Sequence LLPS PhaSepDB
PhaSePro
LLPSDB
DrLLPS Network xml rdf
Structure
Experiment
  :order   disorder   conflict   PDB cluster   ProS   Pfam Domain   SEG
465
 order/disorder by at least rule
     disorder by at least rule
     order by at least rule
 order/disorder by majority rule
Seq 37-164,206-382 Monomer :
 Evidence X-RAY 2hw6 A Reference
       Region 2hw6 A 37-38 disorder
       Region 2hw6 A 39-164 order
       Region 2hw6 A 206-237 order
       Region 2hw6 A 238-263 disorder
       Region 2hw6 A 264-301 order
       Region 2hw6 A 302-330 disorder
       Region 2hw6 A 331-376 order
       Region 2hw6 A 377-382 disorder
 Evidence X-RAY 2hw6 B Reference
       Region 2hw6 B 37-39 disorder
       Region 2hw6 B 40-164 order
       Region 2hw6 B 206-237 order
       Region 2hw6 B 238-261 disorder
       Region 2hw6 B 262-301 order
       Region 2hw6 B 302-339 disorder
       Region 2hw6 B 340-375 order
       Region 2hw6 B 376-382 disorder
Seq 434-451 Hetero dimer : P28482
 Evidence X-RAY 2y9q B Reference
       Region 2y9q B 434-450 order
       Region 2y9q B 451-451 disorder
Seqphosphorylation
    385-385 Phosphothreonine
    39-39 Phosphoserine
    221-221 Phosphoserine
    226-226 Phosphoserine
    250-250 Phosphothreonine
    255-255 Phosphothreonine
    460-460 Phosphoserine
 
Prediction
NeProc
Disorder 1-40,193-203,389-394,408-465
Order 41-192,204-243,251-388,395-407
ProS 389-394,408-418,423-449
AlphaFold
Disorder 1-41,85-87,165-205,234-275,314-314,392-393,420-465
Order 42-84,88-164,206-233,276-313,315-391,394-419
Pfam Hmmer
PF00069 49-374 4.4e-72
SEG 23-35 ,416-428 ,443-456
Function
Function in SwissProt
May play a role in the response to environmental stress and cytokines. Appears to regulate translation by phosphorylating EIF4E, thus increasing the affinity of this protein for the 7-methylguanosine-containing mRNA cap.