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IID00682
 UniprotQ9HC52
ProteinChromobox protein homolog 8
GeneCBX8
OrganismHomo sapiens
Sequence LLPS PhaSepDB
PhaSePro
LLPSDB
DrLLPS
 Network xml rdf
Structure
Experiment
  :order   disorder   conflict   PDB cluster   ProS   Pfam Domain   SEG
389
 order/disorder by at least rule
     disorder by at least rule
     order by at least rule
 order/disorder by majority rule
Seq 7-61 Monomer :
 Evidence X-RAY 5eq0 A Reference
       Region 5eq0 A 7-61 order
Seq 8-61 Hetero trimer :
 Evidence X-RAY 3i91 B Reference
       Region 3i91 B 8-8 disorder
       Region 3i91 B 9-60 order
       Region 3i91 B 61-61 disorder
 Evidence X-RAY 3i91 A Reference
       Region 3i91 A 8-8 disorder
       Region 3i91 A 9-60 order
       Region 3i91 A 61-61 disorder
Seqdisorder 8-61
 Evidence X-RAY Reference
       Region 8-61 disorder
Seq 327-349 Hetero dimer : IID00552Complex
 Evidence NMR 2n4q A Reference
       Region 2n4q A 327-349 order
       Region 2n4q A 327-328 high_rmsd
       Region 2n4q A 345-349 high_rmsd
SeqProS verified 9-60 Hetero trimer :
       Region 3i91 A 9-60 order
       Region 3i91 B 9-60 order
       Region 8-61 disorder
Seqphosphorylation
    352-352 Phosphoserine
    332-332 Phosphoserine
    311-311 Phosphoserine
    265-265 Phosphoserine
    256-256 Phosphoserine
    191-191 Phosphoserine
    130-130 Phosphoserine
    110-110 Phosphoserine
 
Prediction
NeProc
Disorder 1-6,64-346,382-389
Order 7-63,347-381
ProS 64-72,122-127,139-143,152-156,161-169,182-186,197-200,382-389
AlphaFold
Disorder 1-7,66-150,182-359,382-387,389-389
Order 8-65,151-181,360-381,388-388
Pfam Hmmer
PF00385 11-60 2.7e-19
SEG 51-66 ,82-90 ,134-141 ,148-180 ,186-203 ,310-319
Function
Function in SwissProt
Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility.