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IID00683
UniprotQ9HD15
ProteinSteroid receptor RNA activator 1
GeneSRA1
OrganismHomo sapiens
Sequence LLPS PhaSepDB
PhaSePro
LLPSDB
DrLLPS
xml
Structure
Experiment
  :order   disorder   conflict   PDB cluster   ProS   Pfam Domain   SEG
236
 order/disorder by at least rule
     disorder by at least rule
     order by at least rule
 order/disorder by majority rule
Seq 106-236 Monomer :
 Evidence NMR 2mgx A Reference
       Region 2mgx A 107-236 order
       Region 2mgx A 107-107 high_rmsd
       Region 2mgx A 130-130 high_rmsd
       Region 2mgx A 212-236 high_rmsd
 Evidence X-RAY 4nbo A Reference
       Region 4nbo A 106-108 disorder
       Region 4nbo A 109-210 order
       Region 4nbo A 211-215 disorder
 Evidence X-RAY 4nbo B Reference
       Region 4nbo B 106-108 disorder
       Region 4nbo B 109-210 order
       Region 4nbo B 211-215 disorder
Seqphosphorylation
    75-75 Phosphoserine
    57-57 Phosphoserine
    48-48 Phosphoserine
 
Prediction
NeProc
Disorder 1-92,194-224
Order 93-193
ProS 1-24,215-221
AlphaFold
Disorder 1-25,33-71,75-76,80-87,89-107,222-236
Order 26-32,72-74,77-79,88-88,108-221
Pfam Hmmer
PF07304 63-224 1.8e-135
SEG 57-77 ,198-214
Function
Function in SwissProt
Functional RNA which acts as a transcriptional coactivator that selectively enhances steroid receptor-mediated transactivation ligand-independently through a mechanism involving the modulating N-terminal domain (AF-1) of steroid receptors. Also mediates transcriptional coactivation of steroid receptors ligand-dependently through the steroid-binding domain (AF-2). Enhances cellular proliferation and differentiation and promotes apoptosis in vivo. May play a role in tumorigenesis.