IID00686
Uniprot Q9Y478
Protein 5'-AMP-activated protein kinase subunit beta-1
Gene PRKAB1
Organism Homo sapiens
Sequence
LLPS
Network
xml
rdf
Structure
atLeast majority ProS Experiment
:order disorder conflict PDB cluster ProS Pfam Domain SEG
270
order/disorder by at least rule
disorder by at least rule
order/disorder by majority rule
Seq 1-270 Hetero trimer : IID00660 Complex ,
IID00661 Complex
Region 4cfe B 1-77 disorder
Region 4cfe B 78-173 order
Region 4cfe B 174-189 disorder
Region 4cfe B 190-193 order
Region 4cfe B 194-202 disorder
Region 4cfe B 203-270 order
Region 4cfe D 1-77 disorder
Region 4cfe D 78-170 order
Region 4cfe D 171-188 disorder
Region 4cfe D 189-194 order
Region 4cfe D 195-202 disorder
Region 4cfe D 203-270 order
Region 4cff B 1-77 disorder
Region 4cff B 78-173 order
Region 4cff B 174-186 disorder
Region 4cff B 187-193 order
Region 4cff B 194-202 disorder
Region 4cff B 203-270 order
Region 4cff D 1-77 disorder
Region 4cff D 78-173 order
Region 4cff D 174-188 disorder
Region 4cff D 189-196 order
Region 4cff D 197-202 disorder
Region 4cff D 203-270 order
Region 4zhx B 1-77 disorder
Region 4zhx B 78-172 order
Region 4zhx B 173-188 disorder
Region 4zhx B 189-195 order
Region 4zhx B 196-199 disorder
Region 4zhx B 200-269 order
Region 4zhx B 270-270 disorder
Region 4zhx D 1-77 disorder
Region 4zhx D 78-175 order
Region 4zhx D 176-189 disorder
Region 4zhx D 190-197 order
Region 4zhx D 198-200 disorder
Region 4zhx D 201-269 order
Region 4zhx D 270-270 disorder
Seq 1-270 Hetero hexamer : IID00660 Complex ,
IID00661 Complex
Region 5iso B 1-76 disorder
Region 5iso B 77-180 order
Region 5iso B 181-184 disorder
Region 5iso B 185-193 order
Region 5iso B 194-200 disorder
Region 5iso B 201-270 order
Region 5iso D 1-77 disorder
Region 5iso D 78-143 order
Region 5iso D 144-144 disorder
Region 5iso D 145-172 order
Region 5iso D 173-183 disorder
Region 5iso D 184-193 order
Region 5iso D 194-201 disorder
Region 5iso D 202-270 order
Seq 1-270 Hetero trimer : IID00660 Complex ,
IID00661 Complex ,
Q13131
Region 5ezv D 1-76 disorder
Region 5ezv D 77-179 order
Region 5ezv D 180-185 disorder
Region 5ezv D 186-195 order
Region 5ezv D 196-196 disorder
Region 5ezv D 197-269 order
Region 5ezv D 270-270 disorder
Seq 1-270 Hetero trimer : IID00660 Complex ,
IID00661 Complex ,
Q13131
Region 5ezv B 1-77 disorder
Region 5ezv B 78-176 order
Region 5ezv B 177-184 disorder
Region 5ezv B 185-270 order
24-24 Phosphoserine; by autocatalysis
25-25 Phosphoserine; by autocatalysis
Prediction
ProS 1-5,45-49,55-66,173-199
Disorder 1-75,173-187,195-200
Order 76-172,188-194,201-270
Function
Function in SwissProt
Non-catalytic subunit of AMP-activated protein kinase (AMPK), an energy sensor protein kinase that plays a key role in regulating cellular energy metabolism. In response to reduction of intracellular ATP levels, AMPK activates energy-producing pathways and inhibits energy-consuming processes: inhibits protein, carbohydrate and lipid biosynthesis, as well as cell growth and proliferation. AMPK acts via direct phosphorylation of metabolic enzymes, and by longer-term effects via phosphorylation of transcription regulators. Also acts as a regulator of cellular polarity by remodeling the actin cytoskeleton; probably by indirectly activating myosin. Beta non-catalytic subunit acts as a scaffold on which the AMPK complex assembles, via its C-terminus that bridges alpha (PRKAA1 or PRKAA2) and gamma subunits (PRKAG1, PRKAG2 or PRKAG3).
Biological Process
See also
Diagram with PDB data
PRKAA2/PRKAB1/PRKAG1 Structure of full length human AMPK in complex with a small molecule activator, a benzimidazole derivative (991)