Search Keyword:


Search option:


IID00686
UniprotQ9Y478
Protein5'-AMP-activated protein kinase subunit beta-1
GenePRKAB1
OrganismHomo sapiens
Sequence LLPS PhaSepDB
PhaSePro
LLPSDB
DrLLPS
Network xml rdf
Structure
Experiment
  :order   disorder   conflict   PDB cluster   ProS   Pfam Domain   SEG
270
 order/disorder by at least rule
     disorder by at least rule
     order by at least rule
 order/disorder by majority rule
Seq 1-270 Hetero trimer : IID00660Complex,IID00661Complex
 Evidence X-RAY 4cfe B Reference
       Region 4cfe B 1-77 disorder
       Region 4cfe B 78-173 order
       Region 4cfe B 174-189 disorder
       Region 4cfe B 190-193 order
       Region 4cfe B 194-202 disorder
       Region 4cfe B 203-270 order
 Evidence X-RAY 4cfe D Reference
       Region 4cfe D 1-77 disorder
       Region 4cfe D 78-170 order
       Region 4cfe D 171-188 disorder
       Region 4cfe D 189-194 order
       Region 4cfe D 195-202 disorder
       Region 4cfe D 203-270 order
 Evidence X-RAY 4cff B Reference
       Region 4cff B 1-77 disorder
       Region 4cff B 78-173 order
       Region 4cff B 174-186 disorder
       Region 4cff B 187-193 order
       Region 4cff B 194-202 disorder
       Region 4cff B 203-270 order
 Evidence X-RAY 4cff D Reference
       Region 4cff D 1-77 disorder
       Region 4cff D 78-173 order
       Region 4cff D 174-188 disorder
       Region 4cff D 189-196 order
       Region 4cff D 197-202 disorder
       Region 4cff D 203-270 order
 Evidence X-RAY 4zhx B Reference
       Region 4zhx B 1-77 disorder
       Region 4zhx B 78-172 order
       Region 4zhx B 173-188 disorder
       Region 4zhx B 189-195 order
       Region 4zhx B 196-199 disorder
       Region 4zhx B 200-269 order
       Region 4zhx B 270-270 disorder
 Evidence X-RAY 4zhx D Reference
       Region 4zhx D 1-77 disorder
       Region 4zhx D 78-175 order
       Region 4zhx D 176-189 disorder
       Region 4zhx D 190-197 order
       Region 4zhx D 198-200 disorder
       Region 4zhx D 201-269 order
       Region 4zhx D 270-270 disorder
Seq 1-270 Hetero hexamer : IID00660Complex,IID00661Complex
 Evidence X-RAY 5iso B Reference
       Region 5iso B 1-76 disorder
       Region 5iso B 77-180 order
       Region 5iso B 181-184 disorder
       Region 5iso B 185-193 order
       Region 5iso B 194-200 disorder
       Region 5iso B 201-270 order
 Evidence X-RAY 5iso D Reference
       Region 5iso D 1-77 disorder
       Region 5iso D 78-143 order
       Region 5iso D 144-144 disorder
       Region 5iso D 145-172 order
       Region 5iso D 173-183 disorder
       Region 5iso D 184-193 order
       Region 5iso D 194-201 disorder
       Region 5iso D 202-270 order
Seq 1-270 Hetero trimer : IID00660Complex,IID00661Complex,Q13131
 Evidence X-RAY 5ezv D Reference
       Region 5ezv D 1-76 disorder
       Region 5ezv D 77-179 order
       Region 5ezv D 180-185 disorder
       Region 5ezv D 186-195 order
       Region 5ezv D 196-196 disorder
       Region 5ezv D 197-269 order
       Region 5ezv D 270-270 disorder
Seq 1-270 Hetero trimer : IID00660Complex,IID00661Complex,Q13131
 Evidence X-RAY 5ezv B Reference
       Region 5ezv B 1-77 disorder
       Region 5ezv B 78-176 order
       Region 5ezv B 177-184 disorder
       Region 5ezv B 185-270 order
Seqphosphorylation
    101-101 Phosphoserine
    4-4 Phosphothreonine
    5-5 Phosphoserine
    6-6 Phosphoserine
    19-19 Phosphothreonine
    24-24 Phosphoserine; by autocatalysis
    25-25 Phosphoserine; by autocatalysis
    40-40 Phosphoserine
    96-96 Phosphoserine
    108-108 Phosphoserine
    148-148 Phosphothreonine
    182-182 Phosphoserine
 
Prediction
NeProc
Disorder 1-74,173-199
Order 75-172,200-270
ProS 1-5,45-49,55-66,173-199
AlphaFold
Disorder 1-75,173-187,195-200
Order 76-172,188-194,201-270
Pfam Hmmer
PF04739 180-270 9.4e-49
SEG 257-268
Function
Function in SwissProt
Non-catalytic subunit of AMP-activated protein kinase (AMPK), an energy sensor protein kinase that plays a key role in regulating cellular energy metabolism. In response to reduction of intracellular ATP levels, AMPK activates energy-producing pathways and inhibits energy-consuming processes: inhibits protein, carbohydrate and lipid biosynthesis, as well as cell growth and proliferation. AMPK acts via direct phosphorylation of metabolic enzymes, and by longer-term effects via phosphorylation of transcription regulators. Also acts as a regulator of cellular polarity by remodeling the actin cytoskeleton; probably by indirectly activating myosin. Beta non-catalytic subunit acts as a scaffold on which the AMPK complex assembles, via its C-terminus that bridges alpha (PRKAA1 or PRKAA2) and gamma subunits (PRKAG1, PRKAG2 or PRKAG3).
Biological Process
See also
Diagram with PDB data
PRKAA2/PRKAB1/PRKAG1Structure of full length human AMPK in complex with a small molecule activator, a benzimidazole derivative (991)