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IID00690
UniprotO14746
ProteinTelomerase reverse transcriptase
GeneTERT
OrganismHomo sapiens
Sequence LLPS PhaSepDB
PhaSePro
LLPSDB
DrLLPS
Network xml rdf
Structure
Experiment
  :order   disorder   conflict   PDB cluster   ProS   Pfam Domain   SEG
1132
 order/disorder by at least rule
     disorder by at least rule
     order by at least rule
 order/disorder by majority rule
Seq 222-240 Hetero dimer : P52294
 Evidence X-RAY 4b18 B Reference
       Region 4b18 B 222-224 order
       Region 4b18 B 225-228 disorder
       Region 4b18 B 229-240 order
Seq 461-469 Hetero trimer : P05534
 Evidence X-RAY 2bck F Reference
       Region 2bck F 461-469 order
 Evidence X-RAY 2bck C Reference
       Region 2bck C 461-469 order
Seq 540-548 Hetero pentamer : H2RG00,K7N5N2,P01850,P01892
 Evidence X-RAY 4mnq C Reference
       Region 4mnq C 540-548 order
SeqProS possible 222-224,229-240 Nuclear Localization Signal (NLS) Hetero dimer : P52294
       Region 4b18 B 222-224 order
       Region 4b18 B 229-240 order
Seqphosphorylation
    707-707 Phosphotyrosine; by SRC-type Tyr-kinases
    457-457 Phosphoserine; by DYRK2
    227-227 Phosphoserine; by PKB/AKT1
 
Prediction
NeProc
Disorder 1-6,182-357,372-383,421-446,643-650,751-756,780-785,965-970
Order 7-181,358-371,384-420,447-642,651-750,757-779,786-964,971-1132
ProS 182-185,196-357,372-383,443-446,643-650,751-756,965-970
AlphaFold
Disorder 1-2,105-110,179-323,368-380,417-443,524-526,610-610,612-617,636-654,751-753,911-917,1058-1060,1062-1062
Order 3-104,111-178,324-367,381-416,444-523,527-609,611-611,618-635,655-750,754-910,918-1057,1061-1061,1063-1132
SEG 138-153 ,213-248 ,313-323 ,341-354 ,858-872
Function
Function in SwissProt
Telomerase is a ribonucleoprotein enzyme essential for the replication of chromosome termini in most eukaryotes. Active in progenitor and cancer cells. Inactive, or very low activity, in normal somatic cells. Catalytic component of the teleromerase holoenzyme complex whose main activity is the elongation of telomeres by acting as a reverse transcriptase that adds simple sequence repeats to chromosome ends by copying a template sequence within the RNA component of the enzyme. Catalyzes the RNA-dependent extension of 3'-chromosomal termini with the 6-nucleotide telomeric repeat unit, 5'-TTAGGG-3'. The catalytic cycle involves primer binding, primer extension and release of product once the template boundary has been reached or nascent product translocation followed by further extension. More active on substrates containing 2 or 3 telomeric repeats. Telomerase activity is regulated by a number of factors including telomerase complex-associated proteins, chaperones and polypeptide modifiers. Modulates Wnt signaling. Plays important roles in aging and antiapoptosis.
Biological Process
Diagram with PDB data
TERT/KPNA1The crystal structure of human Importin alpha 5 with TERT NLS peptide