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IID00691
 UniprotO43426
ProteinSynaptojanin-1
GeneSYNJ1
OrganismHomo sapiens
Sequence LLPS PhaSepDB
PhaSePro
LLPSDB
DrLLPS Network xml rdf
Structure
Experiment
  :order   disorder   conflict   PDB cluster   ProS   Pfam Domain   SEG
1573
 order/disorder by at least rule
     disorder by at least rule
     order by at least rule
 order/disorder by majority rule
Seq 894-971 Monomer :
 Evidence NMR 2dnr A Reference
       Region 2dnr A 894-971 order
Seq 1458-1469,1477-1488 Hetero trimer : P17427
 Evidence X-RAY 1w80 Q Reference
       Region 1w80 Q 1458-1458 disorder
       Region 1w80 Q 1459-1466 order
       Region 1w80 Q 1467-1469 disorder
 Evidence X-RAY 1w80 P Reference
       Region 1w80 P 1477-1477 disorder
       Region 1w80 P 1478-1485 order
       Region 1w80 P 1486-1488 disorder
Seq 1477-1488 Hetero trimer : P17427
 Evidence X-RAY 2vj0 P Reference
       Region 2vj0 P 1477-1477 disorder
       Region 2vj0 P 1478-1485 order
       Region 2vj0 P 1486-1488 disorder
Seqphosphorylation
    1565-1565 Phosphoserine
    820-820 Phosphoserine
    1551-1551 Phosphoserine
    1349-1349 Phosphothreonine
    1345-1345 Phosphoserine
    1318-1318 Phosphoserine
    1292-1292 Phosphoserine
    1220-1220 Phosphothreonine
    1178-1178 Phosphoserine
    1150-1150 Phosphoserine
    1053-1053 Phosphoserine
    830-830 Phosphoserine
 
Prediction
NeProc
Disorder 822-831,903-908,977-1573
Order 1-821,832-902,909-976
ProS 822-831,1002-1012,1196-1200,1309-1315,1321-1330,1389-1420,1438-1445,1459-1465,1478-1492,1514-1523,1531-1540,1554-1560,1566-1573
AlphaFold
Disorder 1-2,69-73,108-113,261-267,341-343,443-456,458-460,462-467,482-486,499-513,545-556,577-578,594-595,597-604,665-665,822-838,903-907,980-997,1000-1010,1012-1573
Order 3-68,74-107,114-260,268-340,344-442,457-457,461-461,468-481,487-498,514-544,557-576,579-593,596-596,605-664,666-821,839-902,908-979,998-999,1011-1011
Pfam Hmmer
PF02383 59-347 8.3e-153
PF03372 535-866 3.5e-45
SEG 1025-1054 ,1099-1137 ,1177-1190 ,1276-1304 ,1534-1556
Function
Function in SwissProt
Phosphatase that acts on various phosphoinositides, including phosphatidylinositol 4-phosphate, phosphatidylinositol (4,5)-bisphosphate and phosphatidylinositol (3,4,5)-trisphosphate (PubMed:27435091). Has a role in clathrin-mediated endocytosis (By similarity). Hydrolyzes PIP2 bound to actin regulatory proteins resulting in the rearrangement of actin filaments downstream of tyrosine kinase and ASH/GRB2 (By similarity).