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IID00693
 UniprotO43665
ProteinRegulator of G-protein signaling 10
GeneRGS10
OrganismHomo sapiens
Sequence LLPS PhaSepDB
PhaSePro
LLPSDB
DrLLPS
 Network xml rdf
Structure
Experiment
  :order   disorder   conflict   PDB cluster   ProS   Pfam Domain   SEG
173
 order/disorder by at least rule
     disorder by at least rule
     order by at least rule
 order/disorder by majority rule
Seq 9-152 Hetero dimer : P08754
 Evidence X-RAY 2ihb B Reference
       Region 2ihb B 9-23 disorder
       Region 2ihb B 24-102 order
       Region 2ihb B 103-113 disorder
       Region 2ihb B 114-145 order
       Region 2ihb B 146-152 disorder
Seq 22-158 Monomer :
 Evidence NMR 2i59 A Reference
       Region 2i59 A 22-157 order
 Evidence NMR 2dlr A Reference
       Region 2dlr A 23-158 order
Seqphosphorylation
    24-24 Phosphoserine
    41-41 Phosphoserine
    176-176 Phosphoserine
 
Prediction
NeProc
Disorder 1-33,159-181
Order 34-158
ProS 1-11,30-33,176-181
AlphaFold
Disorder 1-32,164-181
Order 33-163
Pfam Hmmer
PF00615 41-156 3.4e-31
SEG 16-34
Function
Function in SwissProt
Regulates G protein-coupled receptor signaling cascades, including signaling downstream of the muscarinic acetylcholine receptor CHRM2. Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits, thereby driving them into their inactive GDP-bound form (PubMed:8774883, PubMed:10608901, PubMed:9353196, PubMed:11443111, PubMed:18434541). Modulates the activity of potassium channels that are activated in response to CHRM2 signaling (PubMed:11443111). Activity on GNAZ is inhibited by palmitoylation of the G-protein (PubMed:9353196).