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IID00694
 UniprotO60880
ProteinSH2 domain-containing protein 1A
GeneSH2D1A
OrganismHomo sapiens
Sequence LLPS PhaSepDB
PhaSePro
LLPSDB
DrLLPS
 Network xml rdf
Structure
Experiment
  :order   disorder   conflict   PDB cluster   ProS   Pfam Domain   SEG
128
 order/disorder by at least rule
     disorder by at least rule
     order by at least rule
 order/disorder by majority rule
Seq 1-104 Hetero tetramer : IID00722Complex
 Evidence X-RAY 1d4w B Reference
       Region 1d4w B 1-2 disorder
       Region 1d4w B 3-104 order
 Evidence X-RAY 1d4w A Reference
       Region 1d4w A 1-104 order
Seq 1-104 Hetero trimer : IID00698Complex,IID00722Complex
 Evidence X-RAY 1m27 A Reference
       Region 1m27 A 1-104 order
Seq 1-104 Homo tetramer :
 Evidence X-RAY 1d1z D Reference
       Region 1d1z D 1-3 disorder
       Region 1d1z D 4-104 order
 Evidence X-RAY 1d1z C Reference
       Region 1d1z C 1-3 disorder
       Region 1d1z C 4-104 order
 Evidence X-RAY 1d1z B Reference
       Region 1d1z B 1-3 disorder
       Region 1d1z B 4-57 order
       Region 1d1z B 58-64 disorder
       Region 1d1z B 65-104 order
 Evidence X-RAY 1d1z A Reference
       Region 1d1z A 1-3 disorder
       Region 1d1z A 4-104 order
Seq 1-128 Hetero dimer : IID00722Complex
 Evidence NMR 1ka7 A Reference
       Region 1ka7 A 1-107 order
       Region 1ka7 A 108-128 disorder
 Evidence NMR 1ka6 A Reference
       Region 1ka6 A 1-107 order
       Region 1ka6 A 108-128 disorder
 Evidence X-RAY 1d4t A Reference
       Region 1d4t A 1-104 order
Seqacetylation
    89-89 N6-acetyllysine
 
Prediction
NeProc
Disorder 111-128
Order 1-105
ProS 111-128
AlphaFold
Disorder 1-2,106-128
Order 3-105
Pfam Hmmer
PF00017 7-87 4e-10
Function
Function in SwissProt
Cytoplasmic adapter regulating receptors of the signaling lymphocytic activation molecule (SLAM) family such as SLAMF1, CD244, LY9, CD84, SLAMF6 and SLAMF7. In SLAM signaling seems to cooperate with SH2D1B/EAT-2. Initially it has been proposed that association with SLAMF1 prevents SLAMF1 binding to inhibitory effectors including INPP5D/SHIP1 and PTPN11/SHP-2 (PubMed:11806999). However, by simultaneous interactions, recruits FYN which subsequently phosphorylates and activates SLAMF1 (PubMed:12458214). Positively regulates CD244/2B4- and CD84-mediated natural killer (NK) cell functions. Can also promote CD48-, SLAMF6 -, LY9-, and SLAMF7-mediated NK cell activation. In the context of NK cell-mediated cytotoxicity enhances conjugate formation with target cells (By similarity). May also regulate the activity of the neurotrophin receptors NTRK1, NTRK2 and NTRK3.