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IID00695
 UniprotO75909
ProteinCyclin-K
GeneCCNK
OrganismHomo sapiens
Sequence LLPS PhaSepDB
PhaSePro
LLPSDB
DrLLPS
 Network xml rdf
Structure
Experiment
  :order   disorder   conflict   PDB cluster   ProS   Pfam Domain   SEG
580
 order/disorder by at least rule
     disorder by at least rule
     order by at least rule
 order/disorder by majority rule
Seq 1-267 Hetero tetramer : Q9NYV4
 Evidence X-RAY 4nst D Reference
       Region 4nst D 1-20 disorder
       Region 4nst D 21-261 order
       Region 4nst D 262-267 disorder
 Evidence X-RAY 4nst B Reference
       Region 4nst B 1-19 disorder
       Region 4nst B 20-265 order
       Region 4nst B 266-267 disorder
Seq 1-267 Hetero dimer : IID00723Complex
 Evidence X-RAY 5efq D Reference
       Region 5efq D 1-20 disorder
       Region 5efq D 21-259 order
       Region 5efq D 260-267 disorder
 Evidence X-RAY 5efq B Reference
       Region 5efq B 1-20 disorder
       Region 5efq B 21-262 order
       Region 5efq B 263-267 disorder
Seq 1-267 Hetero dimer : Q9NYV4
 Evidence X-RAY 4un0 B Reference
       Region 4un0 B 11-21 disorder
       Region 4un0 B 22-229 order
       Region 4un0 B 230-231 disorder
       Region 4un0 B 232-260 order
       Region 4un0 B 261-267 disorder
 Evidence X-RAY 4un0 A Reference
       Region 4un0 A 11-21 disorder
       Region 4un0 A 22-260 order
       Region 4un0 A 261-267 disorder
 Evidence X-RAY 4cxa B Reference
       Region 4cxa B 11-19 disorder
       Region 4cxa B 20-265 order
       Region 4cxa B 266-267 disorder
 Evidence X-RAY 4cxa D Reference
       Region 4cxa D 11-21 disorder
       Region 4cxa D 22-262 order
       Region 4cxa D 263-267 disorder
 Evidence X-RAY 6b3e D Reference
       Region 6b3e D 1-20 disorder
       Region 6b3e D 21-261 order
       Region 6b3e D 262-267 disorder
 Evidence X-RAY 6b3e B Reference
       Region 6b3e B 1-19 disorder
       Region 6b3e B 20-259 order
       Region 6b3e B 260-267 disorder
Seq 11-267 Monomer :
 Evidence X-RAY 2i53 A Reference
       Region 2i53 A 11-13 disorder
       Region 2i53 A 14-267 order
Seq 11-267 Hetero tetramer : Q9NYV4
 Evidence X-RAY 5acb B Reference
       Region 5acb B 11-19 disorder
       Region 5acb B 20-267 order
 Evidence X-RAY 5acb A Reference
       Region 5acb A 11-19 disorder
       Region 5acb A 20-227 order
       Region 5acb A 228-231 disorder
       Region 5acb A 232-260 order
       Region 5acb A 261-267 disorder
Seqphosphorylation
    329-329 Phosphoserine
    328-328 Phosphoserine
    340-340 Phosphoserine
    324-324 Phosphoserine
 
Prediction
NeProc
Disorder 1-20,262-580
Order 21-261
ProS 16-20,534-544,571-580
AlphaFold
Disorder 1-19,260-481,487-487,490-508,510-580
Order 20-259,482-486,488-489,509-509
Pfam Hmmer
PF00134 18-156 1e-06
SEG 263-332 ,341-390 ,402-444 ,455-574
Function
Function in SwissProt
Regulatory subunit of cyclin-dependent kinases that mediates activation of target kinases. Plays a role in transcriptional regulation via its role in regulating the phosphorylation of the C-terminal domain (CTD) of the large subunit of RNA polymerase II (POLR2A).