Search Keyword:


Search option:


IID00699
UniprotP06454
ProteinProthymosin alpha
GenePTMA
OrganismHomo sapiens
Sequence LLPS PhaSepDB
PhaSePro
LLPSDB
DrLLPS
xml
Structure
Experiment
  :order   disorder   conflict   PDB cluster   ProS   Pfam Domain   SEG
111
 order/disorder by at least rule
     disorder by at least rule
     order by at least rule
 order/disorder by majority rule
Seqdisorder 1-111
 Evidence NMR¸ CD The structure remains disordered upon binding to histone H1 (P07305)(PubMed=29466338) Reference
       Region 1-111 disorder
Seqdisorder 1-111
 Evidence NMR¸ CD Reference
       Region 1-111 disorder
Seq 2-29 Monomer :
 Evidence NMR 2mnq A Reference
       Region 2mnq A 2-29 order
 Evidence NMR 2l9i A Reference
       Region 2l9i A 2-29 order
Seqphosphorylation
    8-8 Phosphothreonine
    2-2 Phosphoserine
    107-107 Phosphothreonine
    9-9 Phosphoserine
    10-10 Phosphoserine
    13-13 Phosphothreonine
    14-14 Phosphothreonine
    102-102 Phosphothreonine
Seqacetylation
    1-1 N-acetylmethionine
    2-2 N-acetylserine; in Prothymosin alpha
    15-15 N6-acetyllysine; alternate
    103-103 N6-acetyllysine; alternate
 
Prediction
NeProc
Disorder 1-38,67-111
Order 39-66
ProS 1-38,86-111
AlphaFold
Disorder 1-111
Pfam Hmmer
PF03247 2-111 3.6e-68
SEG 18-28 ,32-84 ,93-111
Function
Function in SwissProt
Prothymosin alpha may mediate immune function by conferring resistance to certain opportunistic infections.