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IID00702
 UniprotP08235
ProteinMineralocorticoid receptor
GeneNR3C2
OrganismHomo sapiens
Sequence LLPS PhaSepDB
PhaSePro
LLPSDB
DrLLPS
 Network xml rdf
Structure
Experiment
  :order   disorder   conflict   PDB cluster   ProS   Pfam Domain   SEG
984
 order/disorder by at least rule
     disorder by at least rule
     order by at least rule
 order/disorder by majority rule
Seq 593-671 Homo dimer :
 Evidence X-RAY 4tnt B Reference
       Region 4tnt B 593-599 disorder
       Region 4tnt B 600-671 order
 Evidence X-RAY 4tnt A Reference
       Region 4tnt A 593-599 disorder
       Region 4tnt A 600-671 order
Seq 712-984 Monomer :
 Evidence X-RAY 1ya3 C Reference
       Region 1ya3 C 731-736 disorder
       Region 1ya3 C 737-746 order
       Region 1ya3 C 747-749 disorder
       Region 1ya3 C 750-756 order
       Region 1ya3 C 757-759 disorder
       Region 1ya3 C 760-908 order
       Region 1ya3 C 909-916 disorder
       Region 1ya3 C 917-982 order
       Region 1ya3 C 983-984 disorder
 Evidence X-RAY 1ya3 B Reference
       Region 1ya3 B 731-737 disorder
       Region 1ya3 B 738-752 order
       Region 1ya3 B 753-759 disorder
       Region 1ya3 B 760-908 order
       Region 1ya3 B 909-916 disorder
       Region 1ya3 B 917-982 order
       Region 1ya3 B 983-984 disorder
 Evidence X-RAY 1ya3 A Reference
       Region 1ya3 A 731-736 disorder
       Region 1ya3 A 737-754 order
       Region 1ya3 A 755-759 disorder
       Region 1ya3 A 760-908 order
       Region 1ya3 A 909-916 disorder
       Region 1ya3 A 917-982 order
       Region 1ya3 A 983-984 disorder
 Evidence X-RAY 1y9r B Reference
       Region 1y9r B 731-736 disorder
       Region 1y9r B 737-908 order
       Region 1y9r B 909-918 disorder
       Region 1y9r B 919-984 order
 Evidence X-RAY 1y9r A Reference
       Region 1y9r A 731-736 disorder
       Region 1y9r A 737-908 order
       Region 1y9r A 909-916 disorder
       Region 1y9r A 917-983 order
       Region 1y9r A 984-984 disorder
 Evidence X-RAY 3wfg A Reference
       Region 3wfg A 712-734 disorder
       Region 3wfg A 735-983 order
       Region 3wfg A 984-984 disorder
 Evidence X-RAY 3wff A Reference
       Region 3wff A 712-726 disorder
       Region 3wff A 727-984 order
 Evidence X-RAY 3vhv A Reference
       Region 3vhv A 727-909 order
       Region 3vhv A 910-914 disorder
       Region 3vhv A 915-984 order
 Evidence X-RAY 3vhu A Reference
       Region 3vhu A 712-727 disorder
       Region 3vhu A 728-908 order
       Region 3vhu A 909-914 disorder
       Region 3vhu A 915-982 order
       Region 3vhu A 983-984 disorder
 Evidence X-RAY 4pf3 A Reference
       Region 4pf3 A 712-734 disorder
       Region 4pf3 A 735-983 order
       Region 4pf3 A 984-984 disorder
 Evidence X-RAY 2oax F Reference
       Region 2oax F 731-737 disorder
       Region 2oax F 738-756 order
       Region 2oax F 757-759 disorder
       Region 2oax F 760-907 order
       Region 2oax F 908-911 disorder
       Region 2oax F 912-982 order
       Region 2oax F 983-984 disorder
 Evidence X-RAY 2oax E Reference
       Region 2oax E 731-737 disorder
       Region 2oax E 738-907 order
       Region 2oax E 908-918 disorder
       Region 2oax E 919-982 order
       Region 2oax E 983-984 disorder
 Evidence X-RAY 2oax D Reference
       Region 2oax D 731-737 disorder
       Region 2oax D 738-756 order
       Region 2oax D 757-759 disorder
       Region 2oax D 760-907 order
       Region 2oax D 908-915 disorder
       Region 2oax D 916-982 order
       Region 2oax D 983-984 disorder
 Evidence X-RAY 2oax C Reference
       Region 2oax C 731-737 disorder
       Region 2oax C 738-756 order
       Region 2oax C 757-759 disorder
       Region 2oax C 760-909 order
       Region 2oax C 910-918 disorder
       Region 2oax C 919-982 order
       Region 2oax C 983-984 disorder
 Evidence X-RAY 2oax B Reference
       Region 2oax B 731-738 disorder
       Region 2oax B 739-907 order
       Region 2oax B 908-918 disorder
       Region 2oax B 919-982 order
       Region 2oax B 983-984 disorder
 Evidence X-RAY 2oax A Reference
       Region 2oax A 731-737 disorder
       Region 2oax A 738-756 order
       Region 2oax A 757-759 disorder
       Region 2oax A 760-908 order
       Region 2oax A 909-917 disorder
       Region 2oax A 918-982 order
       Region 2oax A 983-984 disorder
 Evidence X-RAY 5hcv C Reference
       Region 5hcv C 732-737 disorder
       Region 5hcv C 738-754 order
       Region 5hcv C 755-758 disorder
       Region 5hcv C 759-907 order
       Region 5hcv C 908-916 disorder
       Region 5hcv C 917-971 order
       Region 5hcv C 972-974 disorder
       Region 5hcv C 975-982 order
       Region 5hcv C 983-984 disorder
 Evidence X-RAY 5hcv B Reference
       Region 5hcv B 732-737 disorder
       Region 5hcv B 738-754 order
       Region 5hcv B 755-758 disorder
       Region 5hcv B 759-907 order
       Region 5hcv B 908-916 disorder
       Region 5hcv B 917-982 order
       Region 5hcv B 983-984 disorder
 Evidence X-RAY 5hcv A Reference
       Region 5hcv A 732-737 disorder
       Region 5hcv A 738-754 order
       Region 5hcv A 755-758 disorder
       Region 5hcv A 759-907 order
       Region 5hcv A 908-912 disorder
       Region 5hcv A 913-982 order
       Region 5hcv A 983-984 disorder
 Evidence X-RAY 2abi C Reference
       Region 2abi C 731-736 disorder
       Region 2abi C 737-755 order
       Region 2abi C 756-759 disorder
       Region 2abi C 760-908 order
       Region 2abi C 909-916 disorder
       Region 2abi C 917-982 order
       Region 2abi C 983-984 disorder
 Evidence X-RAY 2abi B Reference
       Region 2abi B 731-736 disorder
       Region 2abi B 737-755 order
       Region 2abi B 756-759 disorder
       Region 2abi B 760-908 order
       Region 2abi B 909-916 disorder
       Region 2abi B 917-982 order
       Region 2abi B 983-984 disorder
 Evidence X-RAY 2abi A Reference
       Region 2abi A 731-736 disorder
       Region 2abi A 737-753 order
       Region 2abi A 754-760 disorder
       Region 2abi A 761-908 order
       Region 2abi A 909-917 disorder
       Region 2abi A 918-982 order
       Region 2abi A 983-984 disorder
 Evidence X-RAY 2aa7 A Reference
       Region 2aa7 A 712-726 disorder
       Region 2aa7 A 727-909 order
       Region 2aa7 A 910-913 disorder
       Region 2aa7 A 914-983 order
       Region 2aa7 A 984-984 disorder
 Evidence X-RAY 2aa6 B Reference
       Region 2aa6 B 712-721 disorder
       Region 2aa6 B 722-908 order
       Region 2aa6 B 909-910 disorder
       Region 2aa6 B 911-982 order
       Region 2aa6 B 983-984 disorder
 Evidence X-RAY 2aa6 A Reference
       Region 2aa6 A 712-721 disorder
       Region 2aa6 A 722-910 order
       Region 2aa6 A 911-911 disorder
       Region 2aa6 A 912-982 order
       Region 2aa6 A 983-984 disorder
 Evidence X-RAY 2aa5 B Reference
       Region 2aa5 B 712-722 disorder
       Region 2aa5 B 723-907 order
       Region 2aa5 B 908-912 disorder
       Region 2aa5 B 913-982 order
       Region 2aa5 B 983-984 disorder
 Evidence X-RAY 2aa5 A Reference
       Region 2aa5 A 712-721 disorder
       Region 2aa5 A 722-910 order
       Region 2aa5 A 911-916 disorder
       Region 2aa5 A 917-982 order
       Region 2aa5 A 983-984 disorder
 Evidence X-RAY 2aa2 A Reference
       Region 2aa2 A 712-726 disorder
       Region 2aa2 A 727-908 order
       Region 2aa2 A 909-913 disorder
       Region 2aa2 A 914-983 order
       Region 2aa2 A 984-984 disorder
Seq 712-984 Homo dimer :
 Evidence X-RAY 2ab2 B Reference
       Region 2ab2 B 712-722 disorder
       Region 2ab2 B 723-908 order
       Region 2ab2 B 909-909 disorder
       Region 2ab2 B 910-982 order
       Region 2ab2 B 983-984 disorder
 Evidence X-RAY 2ab2 A Reference
       Region 2ab2 A 712-722 disorder
       Region 2ab2 A 723-910 order
       Region 2ab2 A 911-911 disorder
       Region 2ab2 A 912-982 order
       Region 2ab2 A 983-984 disorder
 Evidence X-RAY 2aax B Reference
       Region 2aax B 712-722 disorder
       Region 2aax B 723-908 order
       Region 2aax B 909-911 disorder
       Region 2aax B 912-982 order
       Region 2aax B 983-984 disorder
 Evidence X-RAY 2aax A Reference
       Region 2aax A 712-721 disorder
       Region 2aax A 722-910 order
       Region 2aax A 911-911 disorder
       Region 2aax A 912-983 order
       Region 2aax A 984-984 disorder
Seq 732-984 Hetero dimer : IID00083Complex
 Evidence X-RAY 4udb A Reference
       Region 4udb A 735-736 disorder
       Region 4udb A 737-755 order
       Region 4udb A 756-758 disorder
       Region 4udb A 759-983 order
       Region 4udb A 984-984 disorder
 Evidence X-RAY 4uda A Reference
       Region 4uda A 735-737 disorder
       Region 4uda A 738-909 order
       Region 4uda A 910-913 disorder
       Region 4uda A 914-983 order
       Region 4uda A 984-984 disorder
 Evidence X-RAY 5l7h A Reference
       Region 5l7h A 735-736 disorder
       Region 5l7h A 737-912 order
       Region 5l7h A 913-913 disorder
       Region 5l7h A 914-984 order
 Evidence X-RAY 5l7g A Reference
       Region 5l7g A 735-736 disorder
       Region 5l7g A 737-912 order
       Region 5l7g A 913-913 disorder
       Region 5l7g A 914-984 order
 Evidence X-RAY 5l7e A Reference
       Region 5l7e A 735-736 disorder
       Region 5l7e A 737-910 order
       Region 5l7e A 911-915 disorder
       Region 5l7e A 916-984 order
 Evidence X-RAY 2a3i A Reference
       Region 2a3i A 732-984 order
Seq 735-984 Hetero dimer :
 Evidence X-RAY 5mwp A Reference
       Region 5mwp A 735-736 disorder
       Region 5mwp A 737-909 order
       Region 5mwp A 910-916 disorder
       Region 5mwp A 917-984 order
Seq 735-984 Hetero dimer :
 Evidence X-RAY 5mwy A Reference
       Region 5mwy A 735-736 disorder
       Region 5mwy A 737-908 order
       Region 5mwy A 909-914 disorder
       Region 5mwy A 915-984 order
Seqphosphorylation
    299-299 Phosphoserine
    287-287 Phosphoserine
    259-259 Phosphoserine
    283-283 Phosphoserine
    250-250 Phosphoserine
 
Prediction
NeProc
Disorder 1-106,115-447,461-470,477-595,676-736
Order 107-114,448-460,471-476,600-675,737-984
ProS 4-27,29-30,35-64,71-106,115-147,178-187,208-213,219-231,238-306,314-318,332-344,357-447,461-470,477-496,501-527,546-564,572-592,676-686
AlphaFold
Disorder 1-92,115-599,634-634,672-736,910-915,984-984
Order 93-114,600-633,635-671,737-909,916-983
Pfam Hmmer
PF00105 601-676 4.2e-45
PF00104 774-963 2.4e-46
SEG 259-291 ,344-354 ,584-598 ,686-706
Function
Function in SwissProt
Receptor for both mineralocorticoids (MC) such as aldosterone and glucocorticoids (GC) such as corticosterone or cortisol. Binds to mineralocorticoid response elements (MRE) and transactivates target genes. The effect of MC is to increase ion and water transport and thus raise extracellular fluid volume and blood pressure and lower potassium levels.
Biological Process
See also
Diagram with PDB data
NCOA1/RARACrystal structure of RARalpha ligand binding domain in complex with an agonist ligand (Am580) and a coactivator fragment