IID00702
UniprotP08235
ProteinMineralocorticoid receptor
GeneNR3C2
OrganismHomo sapiens
Sequence LLPS Network xml rdf
Structure
Experiment
  :order   disorder   conflict   PDB cluster   ProS   Pfam Domain   SEG
984
 order/disorder by at least rule
 order/disorder by majority rule
Seqphosphorylation
 
Prediction
NeProc
AlphaFold
Pfam Hmmer
SEG 259-291 ,344-354 ,584-598 ,686-706
Function
Function in SwissProt
Receptor for both mineralocorticoids (MC) such as aldosterone and glucocorticoids (GC) such as corticosterone or cortisol. Binds to mineralocorticoid response elements (MRE) and transactivates target genes. The effect of MC is to increase ion and water transport and thus raise extracellular fluid volume and blood pressure and lower potassium levels.
Biological Process
See also
Diagram with PDB data
NCOA1/RARACrystal structure of RARalpha ligand binding domain in complex with an agonist ligand (Am580) and a coactivator fragment