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IID00706
 UniprotP0DP23
ProteinCalmodulin-1
GeneCALM1
OrganismHomo sapiens
Sequence LLPS PhaSepDB
PhaSePro
LLPSDB
DrLLPS
 Network xml rdf
Structure
Experiment
  :order   disorder   conflict   PDB cluster   ProS   Pfam Domain   SEG
149
 order/disorder by at least rule
     disorder by at least rule
     order by at least rule
 order/disorder by majority rule
Seq 1-149 Hetero dimer :
 Evidence X-RAY 6b8q F Reference
       Region 6b8q F 1-4 disorder
       Region 6b8q F 5-148 order
       Region 6b8q F 149-149 disorder
Seq 1-149 Hetero trimer : Q13936
 Evidence X-RAY 3oxq D Reference
       Region 3oxq D 1-3 disorder
       Region 3oxq D 4-77 order
       Region 3oxq D 78-82 disorder
       Region 3oxq D 83-92 order
       Region 3oxq D 93-101 disorder
       Region 3oxq D 102-110 order
       Region 3oxq D 111-115 disorder
       Region 3oxq D 116-147 order
       Region 3oxq D 148-149 disorder
 Evidence X-RAY 3oxq A Reference
       Region 3oxq A 1-3 disorder
       Region 3oxq A 4-148 order
       Region 3oxq A 149-149 disorder
Seq 1-149 Hetero dimer : Q9UIK4
 Evidence X-RAY 1zuz A Reference
       Region 1zuz A 1-4 disorder
       Region 1zuz A 5-149 order
 Evidence X-RAY 1wrz A Reference
       Region 1wrz A 1-2 disorder
       Region 1wrz A 3-149 order
Seq 1-149 Hetero dimer :
 Evidence X-RAY 6b8p F Reference
       Region 6b8p F 1-3 disorder
       Region 6b8p F 4-148 order
       Region 6b8p F 149-149 disorder
Seq 1-149 Hetero dimer :
 Evidence X-RAY 6b8l H Reference
       Region 6b8l H 1-2 disorder
       Region 6b8l H 3-148 order
       Region 6b8l H 149-149 disorder
Seq 1-149 Hetero trimer : Q99250
 Evidence X-RAY 4jpz I Reference
       Region 4jpz I 1-6 disorder
       Region 4jpz I 7-149 order
 Evidence X-RAY 4jpz C Reference
       Region 4jpz C 1-6 disorder
       Region 4jpz C 7-149 order
Seq 1-149 Hetero dimer : P35228
 Evidence X-RAY 3hr4 H Reference
       Region 3hr4 H 1-3 disorder
       Region 3hr4 H 4-148 order
       Region 3hr4 H 149-149 disorder
 Evidence X-RAY 3hr4 F Reference
       Region 3hr4 F 1-3 disorder
       Region 3hr4 F 4-148 order
       Region 3hr4 F 149-149 disorder
 Evidence X-RAY 3hr4 D Reference
       Region 3hr4 D 1-3 disorder
       Region 3hr4 D 4-148 order
       Region 3hr4 D 149-149 disorder
 Evidence X-RAY 3hr4 B Reference
       Region 3hr4 B 1-3 disorder
       Region 3hr4 B 4-148 order
       Region 3hr4 B 149-149 disorder
Seq 1-149 Hetero dimer : Q14524
 Evidence X-RAY 4ovn E Reference
       Region 4ovn E 1-4 disorder
       Region 4ovn E 5-148 order
       Region 4ovn E 149-149 disorder
 Evidence X-RAY 4ovn D Reference
       Region 4ovn D 1-3 disorder
       Region 4ovn D 4-148 order
       Region 4ovn D 149-149 disorder
 Evidence X-RAY 4ovn C Reference
       Region 4ovn C 1-3 disorder
       Region 4ovn C 4-148 order
       Region 4ovn C 149-149 disorder
 Evidence X-RAY 4ovn B Reference
       Region 4ovn B 1-4 disorder
       Region 4ovn B 5-148 order
       Region 4ovn B 149-149 disorder
 Evidence X-RAY 4ovn A Reference
       Region 4ovn A 1-3 disorder
       Region 4ovn A 4-148 order
       Region 4ovn A 149-149 disorder
Seq 1-149 Hetero dimer : Q15746
 Evidence NMR 2k0f A Reference
       Region 2k0f A 2-5 disorder
       Region 2k0f A 6-147 order
       Region 2k0f A 6-7 high_rmsd
       Region 2k0f A 148-149 disorder
 Evidence X-RAY 5jth A Reference
       Region 5jth A 1-2 disorder
       Region 5jth A 3-149 order
 Evidence X-RAY 5jqa A Reference
       Region 5jqa A 1-2 disorder
       Region 5jqa A 3-149 order
Seq 1-149 Hetero trimer : Q14524
 Evidence X-RAY 4dck B Reference
       Region 4dck B 1-4 disorder
       Region 4dck B 5-21 order
       Region 4dck B 22-27 disorder
       Region 4dck B 28-56 order
       Region 4dck B 57-61 disorder
       Region 4dck B 62-149 order
Seq 1-149 Monomer :
 Evidence NMR 2k0j A Reference
       Region 2k0j A 3-149 order
 Evidence NMR 2k0e A Reference
       Region 2k0e A 2-149 order
 Evidence X-RAY 1y6w A Reference
       Region 1y6w A 2-3 disorder
       Region 1y6w A 4-148 order
       Region 1y6w A 149-149 disorder
 Evidence X-RAY 2v02 A Reference
       Region 2v02 A 2-4 disorder
       Region 2v02 A 5-146 order
       Region 2v02 A 147-149 disorder
 Evidence X-RAY 2v01 A Reference
       Region 2v01 A 2-5 disorder
       Region 2v01 A 6-146 order
       Region 2v01 A 147-149 disorder
 Evidence NMR 5tp5 A Reference
       Region 5tp5 A 2-149 order
 Evidence NMR 2n27 A Reference
       Region 2n27 A 2-149 order
       Region 2n27 A 2-3 high_rmsd
 Evidence NMR 2k61 A Reference
       Region 2k61 A 2-3 disorder
       Region 2k61 A 4-149 order
 Evidence NMR 5ggm A Reference
       Region 5ggm A 2-3 disorder
       Region 5ggm A 4-149 order
 Evidence X-RAY 1ctr A Reference
       Region 1ctr A 2-75 order
       Region 1ctr A 76-81 disorder
       Region 1ctr A 82-148 order
       Region 1ctr A 149-149 disorder
 Evidence X-RAY 1cll A Reference
       Region 1cll A 2-4 disorder
       Region 1cll A 5-148 order
       Region 1cll A 149-149 disorder
 Evidence X-RAY 4bw8 B Reference
       Region 4bw8 B 1-2 disorder
       Region 4bw8 B 3-146 order
       Region 4bw8 B 147-149 disorder
 Evidence X-RAY 4bw8 A Reference
       Region 4bw8 A 1-9 disorder
       Region 4bw8 A 10-147 order
       Region 4bw8 A 148-149 disorder
 Evidence X-RAY 4bw7 C Reference
       Region 4bw7 C 1-146 order
       Region 4bw7 C 147-149 disorder
 Evidence X-RAY 4bw7 A Reference
       Region 4bw7 A 1-10 disorder
       Region 4bw7 A 11-147 order
       Region 4bw7 A 148-149 disorder
Seq 1-149 Hetero dimer : O43526
 Evidence NMR 6feh B Reference
       Region 6feh B 1-1 disorder
       Region 6feh B 2-149 order
       Region 6feh B 2-4 high_rmsd
       Region 6feh B 78-79 high_rmsd
 Evidence NMR 6feg B Reference
       Region 6feg B 1-1 disorder
       Region 6feg B 2-149 order
       Region 6feg B 2-3 high_rmsd
       Region 6feg B 77-77 high_rmsd
Seq 1-149 Monomer : P0DP24,P11799,P42212
 Evidence X-RAY 3o78 A Reference
       Region 3o78 A 1-149 order
Seq 1-149 Hetero dimer : P40136
 Evidence X-RAY 1xfz T Reference
       Region 1xfz T 1-3 disorder
       Region 1xfz T 4-149 order
 Evidence X-RAY 1xfz S Reference
       Region 1xfz S 1-3 disorder
       Region 1xfz S 4-149 order
 Evidence X-RAY 1xfz R Reference
       Region 1xfz R 1-3 disorder
       Region 1xfz R 4-149 order
 Evidence X-RAY 1xfz Q Reference
       Region 1xfz Q 1-3 disorder
       Region 1xfz Q 4-149 order
 Evidence X-RAY 1xfz P Reference
       Region 1xfz P 1-3 disorder
       Region 1xfz P 4-149 order
 Evidence X-RAY 1xfz O Reference
       Region 1xfz O 1-3 disorder
       Region 1xfz O 4-149 order
 Evidence X-RAY 1xfy T Reference
       Region 1xfy T 1-3 disorder
       Region 1xfy T 4-149 order
 Evidence X-RAY 1xfy S Reference
       Region 1xfy S 1-3 disorder
       Region 1xfy S 4-149 order
 Evidence X-RAY 1xfy R Reference
       Region 1xfy R 1-3 disorder
       Region 1xfy R 4-149 order
 Evidence X-RAY 1xfy Q Reference
       Region 1xfy Q 1-3 disorder
       Region 1xfy Q 4-149 order
 Evidence X-RAY 1xfy P Reference
       Region 1xfy P 1-3 disorder
       Region 1xfy P 4-149 order
 Evidence X-RAY 1xfy O Reference
       Region 1xfy O 1-3 disorder
       Region 1xfy O 4-149 order
 Evidence X-RAY 1xfx T Reference
       Region 1xfx T 1-3 disorder
       Region 1xfx T 4-149 order
 Evidence X-RAY 1xfx S Reference
       Region 1xfx S 1-3 disorder
       Region 1xfx S 4-149 order
 Evidence X-RAY 1xfx R Reference
       Region 1xfx R 1-3 disorder
       Region 1xfx R 4-149 order
 Evidence X-RAY 1xfx Q Reference
       Region 1xfx Q 1-3 disorder
       Region 1xfx Q 4-149 order
 Evidence X-RAY 1xfx P Reference
       Region 1xfx P 1-3 disorder
       Region 1xfx P 4-149 order
 Evidence X-RAY 1xfx O Reference
       Region 1xfx O 1-3 disorder
       Region 1xfx O 4-149 order
 Evidence X-RAY 1xfw T Reference
       Region 1xfw T 1-3 disorder
       Region 1xfw T 4-149 order
 Evidence X-RAY 1xfw S Reference
       Region 1xfw S 1-3 disorder
       Region 1xfw S 4-149 order
 Evidence X-RAY 1xfw R Reference
       Region 1xfw R 1-3 disorder
       Region 1xfw R 4-149 order
 Evidence X-RAY 1xfw Q Reference
       Region 1xfw Q 1-3 disorder
       Region 1xfw Q 4-149 order
 Evidence X-RAY 1xfw P Reference
       Region 1xfw P 1-3 disorder
       Region 1xfw P 4-149 order
 Evidence X-RAY 1xfw O Reference
       Region 1xfw O 1-3 disorder
       Region 1xfw O 4-149 order
 Evidence X-RAY 1xfv T Reference
       Region 1xfv T 1-3 disorder
       Region 1xfv T 4-149 order
 Evidence X-RAY 1xfv S Reference
       Region 1xfv S 1-3 disorder
       Region 1xfv S 4-149 order
 Evidence X-RAY 1xfv R Reference
       Region 1xfv R 1-3 disorder
       Region 1xfv R 4-149 order
 Evidence X-RAY 1xfv Q Reference
       Region 1xfv Q 1-3 disorder
       Region 1xfv Q 4-149 order
 Evidence X-RAY 1xfv P Reference
       Region 1xfv P 1-3 disorder
       Region 1xfv P 4-149 order
 Evidence X-RAY 1xfv O Reference
       Region 1xfv O 1-3 disorder
       Region 1xfv O 4-149 order
 Evidence X-RAY 1xfu T Reference
       Region 1xfu T 1-3 disorder
       Region 1xfu T 4-149 order
 Evidence X-RAY 1xfu S Reference
       Region 1xfu S 1-3 disorder
       Region 1xfu S 4-149 order
 Evidence X-RAY 1xfu R Reference
       Region 1xfu R 1-3 disorder
       Region 1xfu R 4-149 order
 Evidence X-RAY 1xfu Q Reference
       Region 1xfu Q 1-3 disorder
       Region 1xfu Q 4-149 order
 Evidence X-RAY 1xfu P Reference
       Region 1xfu P 1-3 disorder
       Region 1xfu P 4-149 order
 Evidence X-RAY 1xfu O Reference
       Region 1xfu O 1-3 disorder
       Region 1xfu O 4-149 order
Seq 1-149 Hetero trimer : Q14524
 Evidence X-RAY 4jq0 C Reference
       Region 4jq0 C 1-6 disorder
       Region 4jq0 C 7-148 order
       Region 4jq0 C 149-149 disorder
Seq 1-149 Hetero dimer :
 Evidence X-RAY 6b8n H Reference
       Region 6b8n H 1-2 disorder
       Region 6b8n H 3-148 order
       Region 6b8n H 149-149 disorder
Seq 1-149 Hetero tetramer : IID00069Complex
 Evidence X-RAY 2r28 B Reference
       Region 2r28 B 1-4 disorder
       Region 2r28 B 5-148 order
       Region 2r28 B 149-149 disorder
 Evidence X-RAY 2r28 A Reference
       Region 2r28 A 1-5 disorder
       Region 2r28 A 6-148 order
       Region 2r28 A 149-149 disorder
Seq 1-149 Hetero dimer :
 Evidence X-RAY 6b8m H Reference
       Region 6b8m H 1-2 disorder
       Region 6b8m H 3-148 order
       Region 6b8m H 149-149 disorder
Seq 1-149 Hetero dimer : Q05096
 Evidence X-RAY 5v7x B Reference
       Region 5v7x B 1-1 disorder
       Region 5v7x B 2-130 order
       Region 5v7x B 131-133 disorder
       Region 5v7x B 134-149 order
 Evidence X-RAY 4l79 B Reference
       Region 4l79 B 1-2 disorder
       Region 4l79 B 3-149 order
Seq 1-149 Monomer : P0DP24,P11799,P42212
 Evidence X-RAY 3o78 B Reference
       Region 3o78 B 1-149 order
Seq 1-149 Hetero dimer : O00159
 Evidence X-RAY 4byf B Reference
       Region 4byf B 1-148 order
       Region 4byf B 149-149 disorder
 Evidence X-RAY 4byf D Reference
       Region 4byf D 1-1 disorder
       Region 4byf D 2-149 order
Seq 1-149 Monomer : P0DP24,P11799,P42212
 Evidence X-RAY 3o77 A Reference
       Region 3o77 A 1-57 order
       Region 3o77 A 58-61 disorder
       Region 3o77 A 62-148 order
       Region 3o77 A 149-149 disorder
Seq 1-149 Hetero tetramer : P51787
 Evidence X-RAY 4v0c D Reference
       Region 4v0c D 1-3 disorder
       Region 4v0c D 4-148 order
       Region 4v0c D 149-149 disorder
 Evidence X-RAY 4v0c C Reference
       Region 4v0c C 1-5 disorder
       Region 4v0c C 6-148 order
       Region 4v0c C 149-149 disorder
 Evidence X-RAY 4umo D Reference
       Region 4umo D 1-5 disorder
       Region 4umo D 6-148 order
       Region 4umo D 149-149 disorder
 Evidence X-RAY 4umo C Reference
       Region 4umo C 1-3 disorder
       Region 4umo C 4-148 order
       Region 4umo C 149-149 disorder
Seq 1-149 Hetero dimer : Q13936
 Evidence X-RAY 2be6 B Reference
       Region 2be6 B 1-4 disorder
       Region 2be6 B 5-79 order
       Region 2be6 B 80-82 disorder
       Region 2be6 B 83-147 order
       Region 2be6 B 148-149 disorder
Seq 1-149 Hetero dimer : Q13557
 Evidence X-RAY 2wel D Reference
       Region 2wel D 1-2 disorder
       Region 2wel D 3-147 order
       Region 2wel D 148-149 disorder
Seq 1-149 Hetero dimer :
 Evidence X-RAY 6b8l F Reference
       Region 6b8l F 1-3 disorder
       Region 6b8l F 4-148 order
       Region 6b8l F 149-149 disorder
Seq 1-149 Hetero dimer : Q13936
 Evidence X-RAY 2f3z A Reference
       Region 2f3z A 2-3 disorder
       Region 2f3z A 4-147 order
       Region 2f3z A 148-149 disorder
 Evidence X-RAY 2f3y A Reference
       Region 2f3y A 2-3 disorder
       Region 2f3y A 4-149 order
 Evidence X-RAY 2be6 C Reference
       Region 2be6 C 1-4 disorder
       Region 2be6 C 5-76 order
       Region 2be6 C 77-82 disorder
       Region 2be6 C 83-147 order
       Region 2be6 C 148-149 disorder
 Evidence X-RAY 2be6 A Reference
       Region 2be6 A 1-3 disorder
       Region 2be6 A 4-78 order
       Region 2be6 A 79-81 disorder
       Region 2be6 A 82-147 order
       Region 2be6 A 148-149 disorder
Seq 1-149 Hetero dimer :
 Evidence X-RAY 6b8q D Reference
       Region 6b8q D 1-5 disorder
       Region 6b8q D 6-148 order
       Region 6b8q D 149-149 disorder
Seq 1-149 Hetero dimer :
 Evidence X-RAY 6b8q B Reference
       Region 6b8q B 1-2 disorder
       Region 6b8q B 3-148 order
       Region 6b8q B 149-149 disorder
Seq 1-149 Hetero dimer :
 Evidence X-RAY 5v03 R Reference
       Region 5v03 R 1-3 disorder
       Region 5v03 R 4-148 order
       Region 5v03 R 149-149 disorder
Seq 1-149 Hetero dimer : F1RAX4
 Evidence X-RAY 5k8q A Reference
       Region 5k8q A 1-2 disorder
       Region 5k8q A 3-78 order
       Region 5k8q A 79-81 disorder
       Region 5k8q A 82-148 order
       Region 5k8q A 149-149 disorder
Seq 1-149 Hetero dimer :
 Evidence X-RAY 6b8p D Reference
       Region 6b8p D 1-2 disorder
       Region 6b8p D 3-148 order
       Region 6b8p D 149-149 disorder
Seq 1-149 Hetero dimer :
 Evidence X-RAY 6b8m F Reference
       Region 6b8m F 1-3 disorder
       Region 6b8m F 4-148 order
       Region 6b8m F 149-149 disorder
Seq 1-149 Hetero dimer :
 Evidence X-RAY 6b8p B Reference
       Region 6b8p B 1-3 disorder
       Region 6b8p B 4-148 order
       Region 6b8p B 149-149 disorder
Seq 1-149 Hetero dimer : Q14524
 Evidence X-RAY 4djc A Reference
       Region 4djc A 1-149 order
Seq 1-149 Hetero dimer :
 Evidence X-RAY 6b8n B Reference
       Region 6b8n B 1-3 disorder
       Region 6b8n B 4-148 order
       Region 6b8n B 149-149 disorder
Seq 1-149 Hetero dimer :
 Evidence X-RAY 6b8l D Reference
       Region 6b8l D 1-3 disorder
       Region 6b8l D 4-148 order
       Region 6b8l D 149-149 disorder
Seq 1-149 Hetero dimer :
 Evidence X-RAY 6b8n D Reference
       Region 6b8n D 1-2 disorder
       Region 6b8n D 3-148 order
       Region 6b8n D 149-149 disorder
Seq 1-149 Hetero dimer :
 Evidence X-RAY 6b8m B Reference
       Region 6b8m B 1-3 disorder
       Region 6b8m B 4-148 order
       Region 6b8m B 149-149 disorder
Seq 1-149
 Evidence X-RAY 5j03 B Reference
       Region 5j03 B 1-2 disorder
       Region 5j03 B 3-148 order
       Region 5j03 B 149-149 disorder
Seq 1-149 Hetero dimer : Q9H2S1
 Evidence X-RAY 5wc5 R Reference
       Region 5wc5 R 5-148 order
 Evidence X-RAY 5wbx R Reference
       Region 5wbx R 5-148 order
 Evidence X-RAY 5v02 R Reference
       Region 5v02 R 1-2 disorder
       Region 5v02 R 3-148 order
       Region 5v02 R 149-149 disorder
Seq 1-149 Hetero dimer : O35433
 Evidence X-RAY 3sui A Reference
       Region 3sui A 1-3 disorder
       Region 3sui A 4-149 order
Seq 1-149 Hetero dimer :
 Evidence X-RAY 6b8q H Reference
       Region 6b8q H 1-2 disorder
       Region 6b8q H 3-148 order
       Region 6b8q H 149-149 disorder
Seq 1-149 Hetero dimer :
 Evidence X-RAY 6b8l B Reference
       Region 6b8l B 1-3 disorder
       Region 6b8l B 4-148 order
       Region 6b8l B 149-149 disorder
Seq 1-149 Hetero dimer : P53355
 Evidence X-RAY 1yr5 A Reference
       Region 1yr5 A 2-3 disorder
       Region 1yr5 A 4-149 order
 Evidence X-RAY 2y4v A Reference
       Region 2y4v A 1-3 disorder
       Region 2y4v A 4-77 order
       Region 2y4v A 78-80 disorder
       Region 2y4v A 81-149 order
Seq 1-149 Hetero trimer : Q13936
 Evidence X-RAY 3oxq C Reference
       Region 3oxq C 1-3 disorder
       Region 3oxq C 4-148 order
       Region 3oxq C 149-149 disorder
 Evidence X-RAY 3oxq B Reference
       Region 3oxq B 1-3 disorder
       Region 3oxq B 4-77 order
       Region 3oxq B 78-82 disorder
       Region 3oxq B 83-92 order
       Region 3oxq B 93-100 disorder
       Region 3oxq B 101-111 order
       Region 3oxq B 112-115 disorder
       Region 3oxq B 116-147 order
       Region 3oxq B 148-149 disorder
Seq 1-149 Hetero dimer : IID00069Complex
 Evidence NMR 2jzi A Reference
       Region 2jzi A 2-149 order
 Evidence X-RAY 4q5u A Reference
       Region 4q5u A 1-3 disorder
       Region 4q5u A 4-148 order
       Region 4q5u A 149-149 disorder
Seq 1-149 Hetero dimer : P40136
 Evidence X-RAY 1sk6 F Reference
       Region 1sk6 F 2-5 disorder
       Region 1sk6 F 6-148 order
       Region 1sk6 F 149-149 disorder
 Evidence X-RAY 1sk6 E Reference
       Region 1sk6 E 2-5 disorder
       Region 1sk6 E 6-148 order
       Region 1sk6 E 149-149 disorder
 Evidence X-RAY 1sk6 D Reference
       Region 1sk6 D 2-5 disorder
       Region 1sk6 D 6-148 order
       Region 1sk6 D 149-149 disorder
 Evidence X-RAY 1s26 F Reference
       Region 1s26 F 2-5 disorder
       Region 1s26 F 6-148 order
       Region 1s26 F 149-149 disorder
 Evidence X-RAY 1s26 E Reference
       Region 1s26 E 2-5 disorder
       Region 1s26 E 6-148 order
       Region 1s26 E 149-149 disorder
 Evidence X-RAY 1s26 D Reference
       Region 1s26 D 2-5 disorder
       Region 1s26 D 6-148 order
       Region 1s26 D 149-149 disorder
 Evidence X-RAY 1lvc F Reference
       Region 1lvc F 1-5 disorder
       Region 1lvc F 6-148 order
       Region 1lvc F 149-149 disorder
 Evidence X-RAY 1lvc E Reference
       Region 1lvc E 1-5 disorder
       Region 1lvc E 6-148 order
       Region 1lvc E 149-149 disorder
 Evidence X-RAY 1lvc D Reference
       Region 1lvc D 1-5 disorder
       Region 1lvc D 6-148 order
       Region 1lvc D 149-149 disorder
 Evidence X-RAY 1k93 F Reference
       Region 1k93 F 6-148 order
       Region 1k93 F 149-149 disorder
 Evidence X-RAY 1k93 E Reference
       Region 1k93 E 6-148 order
       Region 1k93 E 149-149 disorder
 Evidence X-RAY 1k93 D Reference
       Region 1k93 D 6-148 order
       Region 1k93 D 149-149 disorder
Seq 1-149 Hetero dimer :
 Evidence X-RAY 6b8p H Reference
       Region 6b8p H 1-2 disorder
       Region 6b8p H 3-148 order
       Region 6b8p H 149-149 disorder
Seq 1-149 Hetero dimer :
 Evidence X-RAY 6b8n F Reference
       Region 6b8n F 1-3 disorder
       Region 6b8n F 4-148 order
       Region 6b8n F 149-149 disorder
Seq 1-149 Hetero dimer :
 Evidence X-RAY 6b8m D Reference
       Region 6b8m D 1-2 disorder
       Region 6b8m D 3-148 order
       Region 6b8m D 149-149 disorder
Seq 1-149 Hetero octamer : IID00069Complex
 Evidence X-RAY 2w73 A Reference
       Region 2w73 A 1-3 disorder
       Region 2w73 A 4-148 order
       Region 2w73 A 149-149 disorder
 Evidence X-RAY 2w73 B Reference
       Region 2w73 B 1-3 disorder
       Region 2w73 B 4-148 order
       Region 2w73 B 149-149 disorder
 Evidence X-RAY 2w73 E Reference
       Region 2w73 E 1-3 disorder
       Region 2w73 E 4-148 order
       Region 2w73 E 149-149 disorder
 Evidence X-RAY 2w73 F Reference
       Region 2w73 F 1-2 disorder
       Region 2w73 F 3-148 order
       Region 2w73 F 149-149 disorder
Seq 2-78 Hetero dimer : Q13936
 Evidence NMR 2lqc A Reference
       Region 2lqc A 2-78 order
       Region 2lqc A 2-3 high_rmsd
       Region 2lqc A 76-78 high_rmsd
Seq 2-80 Homo dimer :
 Evidence X-RAY 3ucy A Reference
       Region 3ucy A 2-3 disorder
       Region 3ucy A 4-77 order
       Region 3ucy A 78-80 disorder
 Evidence X-RAY 3ucw D Reference
       Region 3ucw D 2-2 disorder
       Region 3ucw D 3-80 order
 Evidence X-RAY 3ucw C Reference
       Region 3ucw C 2-77 order
       Region 3ucw C 78-80 disorder
 Evidence X-RAY 3ucw B Reference
       Region 3ucw B 2-3 disorder
       Region 3ucw B 4-80 order
 Evidence X-RAY 3ucw A Reference
       Region 3ucw A 2-4 disorder
       Region 3ucw A 5-78 order
       Region 3ucw A 79-80 disorder
 Evidence X-RAY 3uct B Reference
       Region 3uct B 2-4 disorder
       Region 3uct B 5-76 order
       Region 3uct B 77-80 disorder
 Evidence X-RAY 3uct A Reference
       Region 3uct A 2-2 disorder
       Region 3uct A 3-78 order
       Region 3uct A 79-80 disorder
Seq 2-80 Monomer :
 Evidence NMR 1sw8 A Reference
       Region 1sw8 A 2-80 order
       Region 1sw8 A 2-2 high_rmsd
 Evidence NMR 1j7o A Reference
       Region 1j7o A 2-77 order
 Evidence NMR 2kug A Reference
       Region 2kug A 2-77 order
 Evidence X-RAY 2i08 A Reference
       Region 2i08 A 3-3 disorder
       Region 2i08 A 4-77 order
       Region 2i08 A 78-79 disorder
 Evidence X-RAY 5dsu A Reference
       Region 5dsu A 3-3 disorder
       Region 5dsu A 4-78 order
Seq 2-148 Hetero dimer : P11799
 Evidence X-RAY 1cdl D Reference
       Region 1cdl D 2-5 disorder
       Region 1cdl D 6-147 order
       Region 1cdl D 148-148 disorder
 Evidence X-RAY 1cdl C Reference
       Region 1cdl C 2-5 disorder
       Region 1cdl C 6-147 order
       Region 1cdl C 148-148 disorder
 Evidence X-RAY 1cdl B Reference
       Region 1cdl B 2-5 disorder
       Region 1cdl B 6-147 order
       Region 1cdl B 148-148 disorder
 Evidence X-RAY 1cdl A Reference
       Region 1cdl A 2-5 disorder
       Region 1cdl A 6-147 order
       Region 1cdl A 148-148 disorder
Seq 2-149 Hetero dimer : P53355
 Evidence X-RAY 2x0g B Reference
       Region 2x0g B 2-6 disorder
       Region 2x0g B 7-74 order
       Region 2x0g B 75-82 disorder
       Region 2x0g B 83-146 order
       Region 2x0g B 147-149 disorder
Seq 2-149 Hetero dimer : IID00302Complex
 Evidence NMR 2m55 A Reference
       Region 2m55 A 2-149 order
       Region 2m55 A 2-3 high_rmsd
Seq 2-149 Hetero dimer : P26645
 Evidence X-RAY 1iwq A Reference
       Region 1iwq A 2-4 disorder
       Region 1iwq A 5-77 order
       Region 1iwq A 78-81 disorder
       Region 1iwq A 82-147 order
       Region 1iwq A 148-149 disorder
Seq 2-149 Hetero dimer : O00418
 Evidence NMR 5j8h A Reference
       Region 5j8h A 2-149 order
Seq 2-149 Hetero dimer : IID00510Complex
 Evidence NMR 2kne A Reference
       Region 2kne A 2-149 order
       Region 2kne A 2-2 high_rmsd
Seq 2-149 Hetero dimer : P29474
 Evidence NMR 2n8j A Reference
       Region 2n8j A 2-149 order
       Region 2n8j A 2-11 high_rmsd
       Region 2n8j A 41-47 high_rmsd
       Region 2n8j A 58-60 high_rmsd
 Evidence NMR 2mg5 A Reference
       Region 2mg5 A 2-149 order
       Region 2mg5 A 2-4 high_rmsd
 Evidence NMR 2ll7 A Reference
       Region 2ll7 A 2-149 order
       Region 2ll7 A 2-3 high_rmsd
Seq 2-149 Hetero dimer : Q14524
 Evidence NMR 2l53 A Reference
       Region 2l53 A 2-149 order
 Evidence X-RAY 1up5 A This entry is chicken calmodulin (P62149). Reference
       Region 1up5 A 2-4 disorder
       Region 1up5 A 5-149 order
Seq 2-149 Hetero dimer : Q9WVC8
 Evidence X-RAY 5dow G Reference
       Region 5dow G 2-147 order
       Region 5dow G 148-149 disorder
 Evidence X-RAY 5dow E Reference
       Region 5dow E 2-148 order
       Region 5dow E 149-149 disorder
 Evidence X-RAY 5dow C Reference
       Region 5dow C 2-147 order
       Region 5dow C 148-149 disorder
 Evidence X-RAY 5dow A Reference
       Region 5dow A 2-149 order
Seq 2-149 Hetero dimer : Q00195
 Evidence NMR 2m0k A Reference
       Region 2m0k A 2-149 order
 Evidence NMR 2m0j A Reference
       Region 2m0j A 2-149 order
Seq 2-149 Hetero dimer : Q05586
 Evidence X-RAY 3bya A Reference
       Region 3bya A 2-3 disorder
       Region 3bya A 4-74 order
       Region 3bya A 75-81 disorder
       Region 3bya A 82-147 order
       Region 3bya A 148-149 disorder
Seq 2-149 Hetero dimer : P25445
 Evidence X-RAY 3ewt A Reference
       Region 3ewt A 2-146 order
       Region 3ewt A 147-149 disorder
 Evidence X-RAY 1up5 B This entry is chicken calmodulin (P62149). Reference
       Region 1up5 B 2-149 order
Seq 2-149 Hetero dimer : Q9H095
 Evidence X-RAY 4m1l A Reference
       Region 4m1l A 2-3 disorder
       Region 4m1l A 4-148 order
       Region 4m1l A 149-149 disorder
 Evidence X-RAY 4lzx A Reference
       Region 4lzx A 2-4 disorder
       Region 4lzx A 5-149 order
Seq 2-149 Hetero dimer : Q05152
 Evidence X-RAY 3dvj A Reference
       Region 3dvj A 2-4 disorder
       Region 3dvj A 5-78 order
       Region 3dvj A 79-82 disorder
       Region 3dvj A 83-148 order
       Region 3dvj A 149-149 disorder
 Evidence X-RAY 3dve A Reference
       Region 3dve A 2-4 disorder
       Region 3dve A 5-78 order
       Region 3dve A 79-82 disorder
       Region 3dve A 83-147 order
       Region 3dve A 148-149 disorder
Seq 2-149 Hetero hexamer : P40136
 Evidence X-RAY 1pk0 F Reference
       Region 1pk0 F 2-5 disorder
       Region 1pk0 F 6-148 order
 Evidence X-RAY 1pk0 E Reference
       Region 1pk0 E 2-5 disorder
       Region 1pk0 E 6-148 order
 Evidence X-RAY 1pk0 D Reference
       Region 1pk0 D 2-5 disorder
       Region 1pk0 D 6-148 order
 Evidence X-RAY 1k90 F Reference
       Region 1k90 F 2-5 disorder
       Region 1k90 F 6-148 order
       Region 1k90 F 149-149 disorder
 Evidence X-RAY 1k90 E Reference
       Region 1k90 E 2-5 disorder
       Region 1k90 E 6-148 order
       Region 1k90 E 149-149 disorder
 Evidence X-RAY 1k90 D Reference
       Region 1k90 D 2-5 disorder
       Region 1k90 D 6-148 order
       Region 1k90 D 149-149 disorder
Seq 2-149 Hetero dimer : P08138
 Evidence X-RAY 3ewv A Reference
       Region 3ewv A 2-4 disorder
       Region 3ewv A 5-149 order
Seq 2-149 Hetero dimer : P27884
 Evidence X-RAY 3dvm A Reference
       Region 3dvm A 2-4 disorder
       Region 3dvm A 5-76 order
       Region 3dvm A 77-79 disorder
       Region 3dvm A 80-147 order
       Region 3dvm A 148-149 disorder
Seq 2-149 Hetero dimer :
 Evidence X-RAY 1l7z A Reference
       Region 1l7z A 2-3 disorder
       Region 1l7z A 4-79 order
       Region 1l7z A 80-81 disorder
       Region 1l7z A 82-147 order
       Region 1l7z A 148-149 disorder
Seq 2-149 Hetero dimer : P35228
 Evidence NMR 2ll6 A Reference
       Region 2ll6 A 2-149 order
       Region 2ll6 A 2-2 high_rmsd
Seq 2-149 Hetero dimer : Q07652
 Evidence X-RAY 3dvk A Reference
       Region 3dvk A 2-4 disorder
       Region 3dvk A 5-78 order
       Region 3dvk A 79-79 disorder
       Region 3dvk A 80-148 order
       Region 3dvk A 149-149 disorder
Seq 2-149 Hetero pentamer : Q13936
 Evidence X-RAY 3g43 D Reference
       Region 3g43 D 2-3 disorder
       Region 3g43 D 4-149 order
 Evidence X-RAY 3g43 C Reference
       Region 3g43 C 2-149 order
 Evidence X-RAY 3g43 B Reference
       Region 3g43 B 2-2 disorder
       Region 3g43 B 3-149 order
 Evidence X-RAY 3g43 A Reference
       Region 3g43 A 2-3 disorder
       Region 3g43 A 4-78 order
       Region 3g43 A 79-149 disorder
Seq 2-149 Hetero dimer : IID50054Complex
 Evidence NMR 2l7l A Reference
       Region 2l7l A 2-149 order
Seq 2-149 Hetero dimer : P23677
 Evidence X-RAY 4upu A Reference
       Region 4upu A 2-3 disorder
       Region 4upu A 4-148 order
       Region 4upu A 149-149 disorder
Seq 2-149 Hetero dimer : P35228
 Evidence NMR 5tp6 A Reference
       Region 5tp6 A 2-149 order
       Region 5tp6 A 2-6 high_rmsd
       Region 5tp6 A 98-99 high_rmsd
       Region 5tp6 A 124-134 high_rmsd
Seq 3-147 Hetero hexamer : Q9HD67
 Evidence X-RAY 5i0i I Reference
       Region 5i0i I 84-112 order
       Region 5i0i I 113-117 disorder
       Region 5i0i I 118-147 order
 Evidence X-RAY 5i0i G Reference
       Region 5i0i G 84-126 order
 Evidence X-RAY 5i0i E Reference
       Region 5i0i E 3-147 order
 Evidence X-RAY 5i0i C Reference
       Region 5i0i C 3-147 order
Seq 3-149 Hetero dimer : P14151
 Evidence NMR 2lgf A Reference
       Region 2lgf A 3-3 disorder
       Region 2lgf A 4-149 order
Seq 4-147 Hetero dimer : P56696
 Evidence X-RAY 4gow D Reference
       Region 4gow D 4-79 order
       Region 4gow D 80-81 disorder
       Region 4gow D 82-147 order
Seq 4-149 Hetero dimer : Q13698
 Evidence X-RAY 2vay A Reference
       Region 2vay A 4-149 order
Seq 5-78 Monomer : P0DP24,P38507
 Evidence X-RAY 5coc A Reference
       Region 5coc A 5-77 order
       Region 5coc A 78-78 disorder
Seq 5-149 Hetero dimer : Q14524
 Evidence X-RAY 5dbr A Reference
       Region 5dbr A 5-149 order
Seq 6-147 Monomer : Q9UKL4
 Evidence NMR 2n6a A Reference
       Region 2n6a A 6-8 disorder
       Region 2n6a A 9-147 order
Seq 10-74 Hetero dimer : Q9QXS1
 Evidence X-RAY 4q57 A Reference
       Region 4q57 A 10-74 order
Seq 47-114 Monomer :
 Evidence NMR 2hf5 A Reference
       Region 2hf5 A 47-114 order
Seq 76-149 Hetero dimer : P0DKX7
 Evidence X-RAY 1zot B Reference
       Region 1zot B 80-148 order
 Evidence X-RAY 1yru B Reference
       Region 1yru B 76-79 disorder
       Region 1yru B 80-148 order
       Region 1yru B 149-149 disorder
 Evidence X-RAY 1yrt B Reference
       Region 1yrt B 76-79 disorder
       Region 1yrt B 80-148 order
       Region 1yrt B 149-149 disorder
Seq 77-149 Hetero dimer : P48539
 Evidence NMR 2n77 A Reference
       Region 2n77 A 77-149 order
       Region 2n77 A 77-79 high_rmsd
Seq 79-149 Monomer :
 Evidence NMR 1j7p A Reference
       Region 1j7p A 83-149 order
 Evidence NMR 2lqp A Reference
       Region 2lqp A 79-149 order
       Region 2lqp A 79-81 high_rmsd
       Region 2lqp A 148-149 high_rmsd
 Evidence NMR 2kuh A Reference
       Region 2kuh A 83-149 order
Seq 94-105 Monomer :
 Evidence NMR 1nkf A Reference
       Region 1nkf A 94-105 order
Seqphosphorylation
    139-139 Phosphotyrosine
    111-111 Phosphothreonine
    102-102 Phosphoserine
    100-100 Phosphotyrosine
    82-82 Phosphoserine
    45-45 Phosphothreonine; by CaMK4
Seqacetylation
    95-95 N6-acetyllysine
    22-22 N6-acetyllysine; alternate
    2-2 N-acetylalanine
 
Prediction
NeProc
Disorder 1-2,149-149
Order 3-148
ProS 1-2
AlphaFold
Disorder 1-5,75-82,148-149
Order 6-74,83-147
Pfam Hmmer
PF00036 12-40 2.1e-09
PF00036 48-76 5.1e-09
PF00036 85-113 5e-10
PF00036 121-149 9.4e-10
Function
Function in SwissProt
Calmodulin mediates the control of a large number of enzymes, ion channels, aquaporins and other proteins through calcium-binding. Among the enzymes to be stimulated by the calmodulin-calcium complex are a number of protein kinases and phosphatases. Together with CCP110 and centrin, is involved in a genetic pathway that regulates the centrosome cycle and progression through cytokinesis (PubMed:16760425). Is a regulator of voltage-dependent L-type calcium channels (PubMed:31454269). Mediates calcium-dependent inactivation of CACNA1C (PubMed:26969752). Positively regulates calcium-activated potassium channel activity of KCNN2 (PubMed:27165696). Forms a potassium channel complex with KCNQ1 and regulates electrophysiological activity of the channel via calcium-binding (PubMed:25441029). Acts as a sensor to modulate the endomplasmic reticulum contacts with other organelles mediated by VMP1:ATP2A2 (PubMed:28890335).
(Microbial infection) Required for Legionella pneumophila SidJ glutamylase activity.
Biological Process
See also
Diagram with PDB data
NFATC1/PPP3CA/PPP3R1Structure of Calcineurin in complex with NFATc1 LxVP peptide
MYLK2/CALM1SOLUTION STRUCTURE OF A CALMODULIN-TARGET PEPTIDE COMPLEX BY MULTIDIMENSIONAL NMR
Mylk/CALM1Calmodulin complexed with calmodulin-binding peptide from smooth muscle myosin light chain kinase
PPP3CA/CALM1Structure of calmodulin bound to its recognition site from calcineurin
Camk1/CALM1Solution structure of Ca2+/calmodulin complexed with a peptide representing the calmodulin-binding domain of calmodulin kinase I
MYLK2/CALM1The complex between Ca-Calmodulin and skeletal muscle myosin light chain kinase from combination of NMR and aqueous and contrast-matched SAXS data
Diagram without PDB data
MYLKCalcium/calmodulin-dependent smooth muscle contraction