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IID00707
 UniprotP10415
ProteinApoptosis regulator Bcl-2
GeneBCL2
OrganismHomo sapiens
Sequence LLPS PhaSepDB
PhaSePro
LLPSDB
DrLLPS Network xml rdf
Structure
Experiment
  :order   disorder   conflict   PDB cluster   ProS   Pfam Domain   SEG
239
 order/disorder by at least rule
     disorder by at least rule
     order by at least rule
 order/disorder by majority rule
Seq 1-34,92-207 Monomer :
 Evidence X-RAY 4lvt A Reference
       Region 4lvt A 1-8 disorder
       Region 4lvt A 9-32 order
       Region 4lvt A 33-34 disorder
       Region 4lvt A 92-204 order
       Region 4lvt A 205-207 disorder
Seq 1-34,92-207 Hetero dimer : IID00720Complex,IID00746Complex
 Evidence X-RAY 5agw B Reference
       Region 5agw B 1-9 disorder
       Region 5agw B 10-31 order
       Region 5agw B 32-34 disorder
       Region 5agw B 92-204 order
       Region 5agw B 205-207 disorder
Seq 1-34,92-207 Monomer :
 Evidence X-RAY 4man A Reference
       Region 4man A 1-7 disorder
       Region 4man A 8-29 order
       Region 4man A 30-34 disorder
       Region 4man A 92-204 order
       Region 4man A 205-207 disorder
Seq 1-34,92-207 Hetero dimer : IID00720Complex,IID00746Complex
 Evidence X-RAY 5agx A Reference
       Region 5agx A 1-7 disorder
       Region 5agx A 8-32 order
       Region 5agx A 33-34 disorder
       Region 5agx A 92-204 order
       Region 5agx A 205-207 disorder
Seq 1-33,92-207 Homo hexamer : IID00720Complex
 Evidence X-RAY 4aq3 F Reference
       Region 4aq3 F 1-8 disorder
       Region 4aq3 F 9-32 order
       Region 4aq3 F 33-33 disorder
       Region 4aq3 F 92-203 order
       Region 4aq3 F 204-207 disorder
 Evidence X-RAY 4aq3 E Reference
       Region 4aq3 E 1-9 disorder
       Region 4aq3 E 10-32 order
       Region 4aq3 E 33-33 disorder
       Region 4aq3 E 92-203 order
       Region 4aq3 E 204-207 disorder
 Evidence X-RAY 4aq3 D Reference
       Region 4aq3 D 1-8 disorder
       Region 4aq3 D 9-31 order
       Region 4aq3 D 32-33 disorder
       Region 4aq3 D 92-203 order
       Region 4aq3 D 204-207 disorder
 Evidence X-RAY 4aq3 C Reference
       Region 4aq3 C 1-8 disorder
       Region 4aq3 C 9-31 order
       Region 4aq3 C 32-33 disorder
       Region 4aq3 C 92-203 order
       Region 4aq3 C 204-207 disorder
 Evidence X-RAY 4aq3 B Reference
       Region 4aq3 B 1-8 disorder
       Region 4aq3 B 9-31 order
       Region 4aq3 B 32-33 disorder
       Region 4aq3 B 92-203 order
       Region 4aq3 B 204-207 disorder
 Evidence X-RAY 4aq3 A Reference
       Region 4aq3 A 1-8 disorder
       Region 4aq3 A 9-31 order
       Region 4aq3 A 32-33 disorder
       Region 4aq3 A 92-203 order
       Region 4aq3 A 204-207 disorder
Seq 1-34,92-207 Monomer :
 Evidence X-RAY 4lvt B Reference
       Region 4lvt B 1-8 disorder
       Region 4lvt B 9-32 order
       Region 4lvt B 33-34 disorder
       Region 4lvt B 92-204 order
       Region 4lvt B 205-207 disorder
Seq 1-34,92-207 Hetero dimer : IID00720Complex,IID00746Complex
 Evidence X-RAY 5agx B Reference
       Region 5agx B 1-7 disorder
       Region 5agx B 8-32 order
       Region 5agx B 33-34 disorder
       Region 5agx B 92-204 order
       Region 5agx B 205-207 disorder
Seq 1-34,54-60,92-207 Hetero dimer : Q99HR6
 Evidence X-RAY 5fcg A Reference
       Region 5fcg A 1-5 disorder
       Region 5fcg A 6-34 order
       Region 5fcg A 54-60 disorder
       Region 5fcg A 92-203 order
       Region 5fcg A 204-207 disorder
Seq 1-34,92-207 Monomer :
 Evidence X-RAY 4lxd A Reference
       Region 4lxd A 1-5 disorder
       Region 4lxd A 6-33 order
       Region 4lxd A 34-34 disorder
       Region 4lxd A 92-204 order
       Region 4lxd A 205-207 disorder
Seq 1-34,92-207 Monomer :
 Evidence X-RAY 4man B Reference
       Region 4man B 1-7 disorder
       Region 4man B 8-29 order
       Region 4man B 30-34 disorder
       Region 4man B 92-204 order
       Region 4man B 205-207 disorder
Seq 1-34,92-207 Monomer :
 Evidence NMR 1gjh A Reference
       Region 1gjh A 1-2 disorder
       Region 1gjh A 3-34 order
       Region 1gjh A 92-207 order
Seq 1-34,92-207 Hetero dimer : IID00720Complex,IID00746Complex
 Evidence X-RAY 5agw A Reference
       Region 5agw A 1-7 disorder
       Region 5agw A 8-31 order
       Region 5agw A 32-34 disorder
       Region 5agw A 92-204 order
       Region 5agw A 205-207 disorder
Seq 1-34,92-207 Monomer : IID00720Complex
 Evidence X-RAY 4ieh A Reference
       Region 4ieh A 1-8 disorder
       Region 4ieh A 9-31 order
       Region 4ieh A 32-34 disorder
       Region 4ieh A 92-204 order
       Region 4ieh A 205-207 disorder
Seq 1-34,92-207 Monomer :
 Evidence NMR 1g5m A Reference
       Region 1g5m A 1-2 disorder
       Region 1g5m A 3-34 order
       Region 1g5m A 92-207 order
Seq 1-207 Hetero dimer : Q07813
 Evidence X-RAY 2xa0 B Reference
       Region 2xa0 B 1-9 disorder
       Region 2xa0 B 10-31 order
       Region 2xa0 B 32-91 disorder
       Region 2xa0 B 92-206 order
       Region 2xa0 B 207-207 disorder
 Evidence X-RAY 2xa0 A Reference
       Region 2xa0 A 1-9 disorder
       Region 2xa0 A 10-31 order
       Region 2xa0 A 32-91 disorder
       Region 2xa0 A 92-206 order
       Region 2xa0 A 207-207 disorder
Seq 1-207 Hetero dimer :
 Evidence X-RAY 5jsn C Reference
       Region 5jsn C 1-6 disorder
       Region 5jsn C 7-32 order
       Region 5jsn C 33-86 disorder
       Region 5jsn C 87-207 order
Seq 1-207 Hetero dimer :
 Evidence X-RAY 5jsn A Reference
       Region 5jsn A 1-6 disorder
       Region 5jsn A 7-32 order
       Region 5jsn A 33-86 disorder
       Region 5jsn A 87-207 order
Seq 3-33,92-206 Monomer :
 Evidence NMR 1ysw A Reference
       Region 1ysw A 3-33 order
       Region 1ysw A 92-206 order
Seq 3-34,92-207 Monomer :
 Evidence NMR 2o21 A Reference
       Region 2o21 A 3-34 order
       Region 2o21 A 92-207 order
Seq 3-34,92-207 Monomer :
 Evidence NMR 2o22 A Reference
       Region 2o22 A 3-34 order
       Region 2o22 A 92-207 order
Seq 8-31,92-204 Monomer :
 Evidence NMR 2o2f A Reference
       Region 2o2f A 8-31 order
       Region 2o2f A 92-204 order
Seq 92-206 Monomer :
 Evidence X-RAY 2w3l B Reference
       Region 2w3l B 92-204 order
       Region 2w3l B 205-206 disorder
 Evidence X-RAY 2w3l A Reference
       Region 2w3l A 92-206 order
Seqphosphorylation
    70-70 Phosphoserine; by MAPK8 and PKC
    87-87 Phosphoserine; by MAPK8
    69-69 Phosphothreonine; by MAPK8
 
Prediction
NeProc
Disorder 1-9,36-90,237-239
Order 10-35,91-236
ProS 1-9,53-58,64-70,237-239
AlphaFold
Disorder 1-7,33-85,204-239
Order 8-32,86-203
Pfam Hmmer
PF02180 7-33 4.6e-14
PF00452 97-195 4.2e-56
SEG 31-47 ,75-93 ,213-225
Function
Function in SwissProt
Suppresses apoptosis in a variety of cell systems including factor-dependent lymphohematopoietic and neural cells. Regulates cell death by controlling the mitochondrial membrane permeability. Appears to function in a feedback loop system with caspases. Inhibits caspase activity either by preventing the release of cytochrome c from the mitochondria and/or by binding to the apoptosis-activating factor (APAF-1). May attenuate inflammation by impairing NLRP1-inflammasome activation, hence CASP1 activation and IL1B release (PubMed:17418785).