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IID00709
 UniprotP19338
ProteinNucleolin
GeneNCL
OrganismHomo sapiens
Sequence LLPS PhaSepDB
PhaSePro
LLPSDB
DrLLPS xml
Structure
Experiment
  :order   disorder   conflict   PDB cluster   ProS   Pfam Domain   SEG
710
 order/disorder by at least rule
     disorder by at least rule
     order by at least rule
 order/disorder by majority rule
Seq 300-466 Monomer :
 Evidence NMR 2krr A Reference
       Region 2krr A 300-466 order
Seq 478-565 Monomer :
 Evidence NMR 2fc9 A Reference
       Region 2fc9 A 478-565 order
Seq 564-652 Monomer :
 Evidence NMR 2fc8 A Reference
       Region 2fc8 A 564-652 order
Seqphosphorylation
    619-619 Phosphoserine
    591-591 Phosphoserine
    580-580 Phosphoserine
    563-563 Phosphoserine
    460-460 Phosphoserine
    458-458 Phosphoserine
    405-405 Phosphothreonine
    367-367 Phosphothreonine
    356-356 Phosphoserine
    301-301 Phosphothreonine
    214-214 Phosphothreonine
    206-206 Phosphoserine
    184-184 Phosphoserine
    153-153 Phosphoserine
    145-145 Phosphoserine
    121-121 Phosphothreonine
    113-113 Phosphothreonine
    106-106 Phosphothreonine
    76-76 Phosphothreonine
    84-84 Phosphothreonine
    92-92 Phosphothreonine
    99-99 Phosphothreonine
    28-28 Phosphoserine
    34-34 Phosphoserine
    41-41 Phosphoserine
    42-42 Phosphoserine
    67-67 Phosphoserine
    69-69 Phosphothreonine
Seqacetylation
    646-646 N6-acetyllysine
    577-577 N6-acetyllysine; alternate
    572-572 N6-acetyllysine
    521-521 N6-acetyllysine
    513-513 N6-acetyllysine; alternate
    467-467 N6-acetyllysine
    477-477 N6-acetyllysine
    444-444 N6-acetyllysine
    427-427 N6-acetyllysine
    403-403 N6-acetyllysine
    398-398 N6-acetyllysine
    377-377 N6-acetyllysine; alternate
    348-348 N6-acetyllysine
    318-318 N6-acetyllysine
    124-124 N6-acetyllysine
    116-116 N6-acetyllysine
    109-109 N6-acetyllysine
    102-102 N6-acetyllysine
    96-96 N6-acetyllysine
    15-15 N6-acetyllysine
    16-16 N6-acetyllysine
    9-9 N6-acetyllysine
 
Prediction
NeProc
Disorder 1-317,373-376,383-390,648-710
Order 318-372,377-382,391-647
ProS 307-317,373-376,648-653,698-710
AlphaFold
Disorder 1-304,381-386,468-485,558-569,632-632,647-708,710-710
Order 305-380,387-467,486-557,570-631,633-646,709-709
Pfam Hmmer
PF00076 309-378 4.9e-06
PF00076 395-461 5.1e-15
PF00076 488-555 2e-18
PF00076 574-642 9.9e-21
SEG 23-47 ,51-63 ,68-107 ,122-212 ,216-271 ,281-297 ,620-632 ,651-698
Function
Function in SwissProt
Nucleolin is the major nucleolar protein of growing eukaryotic cells. It is found associated with intranucleolar chromatin and pre-ribosomal particles. It induces chromatin decondensation by binding to histone H1. It is thought to play a role in pre-rRNA transcription and ribosome assembly. May play a role in the process of transcriptional elongation. Binds RNA oligonucleotides with 5'-UUAGGG-3' repeats more tightly than the telomeric single-stranded DNA 5'-TTAGGG-3' repeats.