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IID00711
 UniprotP25942
ProteinTumor necrosis factor receptor superfamily member 5
GeneCD40
OrganismHomo sapiens
Sequence LLPS PhaSepDB
PhaSePro
LLPSDB
DrLLPS
 Network xml rdf
Structure
Experiment
  :order   disorder   conflict   PDB cluster   ProS   Pfam Domain   SEG
277
 order/disorder by at least rule
     disorder by at least rule
     order by at least rule
 order/disorder by majority rule
Seq 21-190 Hetero pentamer : P29965
 Evidence X-RAY 3qd6 U Reference
       Region 3qd6 U 21-125 order
       Region 3qd6 U 126-131 disorder
       Region 3qd6 U 132-145 order
       Region 3qd6 U 146-190 disorder
 Evidence X-RAY 3qd6 T Reference
       Region 3qd6 T 21-25 disorder
       Region 3qd6 T 26-125 order
       Region 3qd6 T 126-131 disorder
       Region 3qd6 T 132-145 order
       Region 3qd6 T 146-190 disorder
 Evidence X-RAY 3qd6 S Reference
       Region 3qd6 S 21-125 order
       Region 3qd6 S 126-131 disorder
       Region 3qd6 S 132-145 order
       Region 3qd6 S 146-190 disorder
 Evidence X-RAY 3qd6 R Reference
       Region 3qd6 R 21-25 disorder
       Region 3qd6 R 26-125 order
       Region 3qd6 R 126-131 disorder
       Region 3qd6 R 132-145 order
       Region 3qd6 R 146-190 disorder
Seq 21-193 Hetero trimer :
 Evidence X-RAY 6fax R Reference
       Region 6fax R 21-120 order
       Region 6fax R 121-193 disorder
Seq 23-193 Hetero dimer :
 Evidence X-RAY 5ihl D Reference
       Region 5ihl D 23-187 order
       Region 5ihl D 188-193 disorder
Seq 23-193 Hetero dimer :
 Evidence X-RAY 5ihl F Reference
       Region 5ihl F 23-23 disorder
       Region 5ihl F 24-188 order
       Region 5ihl F 189-193 disorder
Seq 23-193 Hetero dimer :
 Evidence X-RAY 5dmj F Reference
       Region 5dmj F 23-25 disorder
       Region 5dmj F 26-188 order
       Region 5dmj F 189-193 disorder
Seq 23-193 Hetero dimer :
 Evidence X-RAY 5dmj A Reference
       Region 5dmj A 23-23 disorder
       Region 5dmj A 24-188 order
       Region 5dmj A 189-193 disorder
Seq 23-193 Hetero dimer :
 Evidence X-RAY 5ihl A Reference
       Region 5ihl A 23-190 order
       Region 5ihl A 191-193 disorder
Seq 23-193 Hetero trimer :
 Evidence X-RAY 5dmi A Reference
       Region 5dmi A 23-23 disorder
       Region 5dmi A 24-121 order
       Region 5dmi A 122-193 disorder
Seq 23-193 Hetero dimer :
 Evidence X-RAY 5dmj D Reference
       Region 5dmj D 23-23 disorder
       Region 5dmj D 24-190 order
       Region 5dmj D 191-193 disorder
Seq 23-193 Hetero dimer :
 Evidence X-RAY 5ihl H Reference
       Region 5ihl H 23-189 order
       Region 5ihl H 190-193 disorder
Seq 230-236 Hetero dimer : IID00744Complex
 Evidence X-RAY 1lb6 B Reference
       Region 1lb6 B 230-236 order
Seq 246-266 Hetero dimer : Q13114
 Evidence X-RAY 1fll Y Reference
       Region 1fll Y 246-266 order
 Evidence X-RAY 1fll X Reference
       Region 1fll X 246-266 order
Seq 250-254 Hetero hexamer : Q12933
 Evidence X-RAY 1d00 J Reference
       Region 1d00 J 250-254 order
 Evidence X-RAY 1d00 P Reference
       Region 1d00 P 250-254 order
 Evidence X-RAY 1d00 O Reference
       Region 1d00 O 250-254 order
 Evidence X-RAY 1d00 N Reference
       Region 1d00 N 250-254 order
 Evidence X-RAY 1d00 M Reference
       Region 1d00 M 250-254 order
 Evidence X-RAY 1d00 L Reference
       Region 1d00 L 250-254 order
 Evidence X-RAY 1d00 K Reference
       Region 1d00 K 250-254 order
 Evidence X-RAY 1d00 I Reference
       Region 1d00 I 250-254 order
Seq 250-258 Hetero pentamer : Q12933
 Evidence X-RAY 1czz E Reference
       Region 1czz E 250-258 order
 Evidence X-RAY 1czz D Reference
       Region 1czz D 250-256 order
       Region 1czz D 257-258 disorder
SeqProS predicted 230-236 The unbound state of this region is predicted to be disordered by DICHOT, FoldIndex and MobiDB. Hetero dimer : IID00744Complex
       Region 1lb6 B 230-236 order
SeqProS predicted 246-266 The unbound state of this region is predicted to be disordered by DICHOT, FoldIndex and MobiDB. Hetero dimer : Q13114
       Region 1fll X 246-266 order
       Region 1fll Y 246-266 order
SeqProS predicted 250-254 The unbound state of this region is predicted to be disordered by DICHOT, FoldIndex and MobiDB. Hetero hexamer : Q12933
       Region 1d00 I 250-254 order
       Region 1d00 J 250-254 order
       Region 1d00 K 250-254 order
       Region 1d00 L 250-254 order
       Region 1d00 M 250-254 order
       Region 1d00 N 250-254 order
       Region 1d00 O 250-254 order
       Region 1d00 P 250-254 order
SeqProS predicted 250-256 The unbound state of this region is predicted to be disordered by DICHOT, FoldIndex and MobiDB. Hetero pentamer : Q12933
       Region 1czz D 250-256 order
       Region 1czz E 250-258 order
 
Prediction
NeProc
Disorder 1-22,180-192,216-277
Order 23-179,193-215
ProS 1-22,180-192,216-228,239-277
AlphaFold
Disorder 1-24,192-194,220-277
Order 25-191,195-219
Pfam Hmmer
PF00020 26-59 2.2e-10
SEG 197-215
Function
Function in SwissProt
Receptor for TNFSF5/CD40LG (PubMed:31331973). Transduces TRAF6- and MAP3K8-mediated signals that activate ERK in macrophages and B cells, leading to induction of immunoglobulin secretion (By similarity).