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IID00712
 UniprotP26196
ProteinProbable ATP-dependent RNA helicase DDX6
GeneDDX6
OrganismHomo sapiens
Sequence LLPS PhaSepDB
PhaSePro
LLPSDB
DrLLPS Network xml rdf
Structure
Experiment
  :order   disorder   conflict   PDB cluster   ProS   Pfam Domain   SEG
483
 order/disorder by at least rule
     disorder by at least rule
     order by at least rule
 order/disorder by majority rule
Seq 94-299 Monomer :
 Evidence X-RAY 1vec B Reference
       Region 1vec B 94-299 order
 Evidence X-RAY 1vec A Reference
       Region 1vec A 94-299 order
Seq 95-469 Hetero dimer : IID00423Complex
 Evidence X-RAY 4ct4 D Reference
       Region 4ct4 D 95-393 order
       Region 4ct4 D 394-397 disorder
       Region 4ct4 D 398-462 order
       Region 4ct4 D 463-469 disorder
 Evidence X-RAY 4ct4 B Reference
       Region 4ct4 B 95-469 order
Seq 95-469 Monomer :
 Evidence X-RAY 4ct5 B Reference
       Region 4ct5 B 95-469 order
 Evidence X-RAY 4ct5 A Reference
       Region 4ct5 A 95-469 order
Seq 296-483 Hetero dimer : Q96F86
 Evidence X-RAY 2way C Reference
       Region 2way C 296-307 disorder
       Region 2way C 308-393 order
       Region 2way C 394-400 disorder
       Region 2way C 401-423 order
       Region 2way C 424-430 disorder
       Region 2way C 431-473 order
       Region 2way C 474-483 disorder
 Evidence X-RAY 2way A Reference
       Region 2way A 296-306 disorder
       Region 2way A 307-393 order
       Region 2way A 394-398 disorder
       Region 2way A 399-423 order
       Region 2way A 424-430 disorder
       Region 2way A 431-471 order
       Region 2way A 472-483 disorder
 Evidence X-RAY 2wax C Reference
       Region 2wax C 296-306 disorder
       Region 2wax C 307-423 order
       Region 2wax C 424-424 disorder
       Region 2wax C 425-472 order
       Region 2wax C 473-483 disorder
 Evidence X-RAY 2wax A Reference
       Region 2wax A 296-307 disorder
       Region 2wax A 308-425 order
       Region 2wax A 426-430 disorder
       Region 2wax A 431-473 order
       Region 2wax A 474-483 disorder
Seq 307-483 Hetero dimer : IID00423Complex
 Evidence X-RAY 4crw B Reference
       Region 4crw B 307-464 order
       Region 4crw B 465-483 disorder
Seqphosphorylation
    36-36 Phosphothreonine
 
Prediction
NeProc
Disorder 1-83,475-483
Order 84-474
ProS 6-22,70-83
AlphaFold
Disorder 1-70,476-483
Order 71-475
Pfam Hmmer
PF00270 120-287 7.8e-61
PF00271 353-429 3.7e-31
SEG 27-41 ,47-60
Function
Function in SwissProt
Essential for the formation of P-bodies, cytosolic membrane-less ribonucleoprotein granules involved in RNA metabolism through the coordinated storage of mRNAs encoding regulatory functions (PubMed:25995375, PubMed:27342281, PubMed:31422817). Plays a role in P-bodies to coordinate the storage of translationally inactive mRNAs in the cytoplasm and prevent their degradation (PubMed:27342281). In the process of mRNA degradation, plays a role in mRNA decapping (PubMed:16364915). Blocks autophagy in nutrient-rich conditions by repressing the expression of ATG-related genes through degradation of their transcripts (PubMed:26098573).