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IID00718
 UniprotP55211
ProteinCaspase-9
GeneCASP9
OrganismHomo sapiens
Sequence LLPS PhaSepDB
PhaSePro
LLPSDB
DrLLPS
 Network xml rdf
Structure
Experiment
  :order   disorder   conflict   PDB cluster   ProS   Pfam Domain   SEG
416
 order/disorder by at least rule
     disorder by at least rule
     order by at least rule
 order/disorder by majority rule
Seq 1-95 Hetero dimer : O14727
 Evidence X-RAY 3ygs P Reference
       Region 3ygs P 1-95 order
Seq 1-100 Hetero hexamer : O14727
 Evidence X-RAY 4rhw E Reference
       Region 4rhw E 1-95 order
       Region 4rhw E 96-100 disorder
 Evidence X-RAY 4rhw F Reference
       Region 4rhw F 1-95 order
       Region 4rhw F 96-100 disorder
Seq 1-128 Hetero hexamer : O14727
 Evidence X-RAY 5wvc F Reference
       Region 5wvc F 1-101 order
       Region 5wvc F 102-128 disorder
 Evidence X-RAY 5wvc D Reference
       Region 5wvc D 1-101 order
       Region 5wvc D 102-128 disorder
 Evidence X-RAY 5wvc B Reference
       Region 5wvc B 1-101 order
       Region 5wvc B 102-128 disorder
Seq 139-416 Homo dimer :
 Evidence X-RAY 1jxq D Reference
       Region 1jxq D 140-147 disorder
       Region 1jxq D 148-289 order
       Region 1jxq D 290-332 disorder
       Region 1jxq D 333-416 order
 Evidence X-RAY 1jxq C Reference
       Region 1jxq C 140-298 order
       Region 1jxq C 299-334 disorder
       Region 1jxq C 335-416 order
 Evidence X-RAY 1jxq B Reference
       Region 1jxq B 140-147 disorder
       Region 1jxq B 148-289 order
       Region 1jxq B 290-332 disorder
       Region 1jxq B 333-416 order
 Evidence X-RAY 1jxq A Reference
       Region 1jxq A 140-298 order
       Region 1jxq A 299-334 disorder
       Region 1jxq A 335-416 order
 Evidence X-RAY 2ar9 D Reference
       Region 2ar9 D 139-139 disorder
       Region 2ar9 D 140-288 order
       Region 2ar9 D 289-334 disorder
       Region 2ar9 D 335-416 order
 Evidence X-RAY 2ar9 C Reference
       Region 2ar9 C 139-139 disorder
       Region 2ar9 C 140-287 order
       Region 2ar9 C 288-334 disorder
       Region 2ar9 C 335-416 order
 Evidence X-RAY 2ar9 B Reference
       Region 2ar9 B 139-139 disorder
       Region 2ar9 B 140-289 order
       Region 2ar9 B 290-334 disorder
       Region 2ar9 B 335-416 order
 Evidence X-RAY 2ar9 A Reference
       Region 2ar9 A 139-139 disorder
       Region 2ar9 A 140-287 order
       Region 2ar9 A 288-334 disorder
       Region 2ar9 A 335-416 order
Seq 140-416 Hetero dimer : P98170
 Evidence X-RAY 1nw9 B Reference
       Region 1nw9 B 140-288 order
       Region 1nw9 B 289-315 disorder
       Region 1nw9 B 316-320 order
       Region 1nw9 B 321-332 disorder
       Region 1nw9 B 333-416 order
Seq 141-416 Hetero dimer : Q8XAL7
 Evidence X-RAY 3v3k O Reference
       Region 3v3k O 141-147 disorder
       Region 3v3k O 148-300 order
       Region 3v3k O 301-332 disorder
       Region 3v3k O 333-416 order
 Evidence X-RAY 3v3k M Reference
       Region 3v3k M 141-300 order
       Region 3v3k M 301-331 disorder
       Region 3v3k M 332-416 order
 Evidence X-RAY 3v3k K Reference
       Region 3v3k K 141-147 disorder
       Region 3v3k K 148-300 order
       Region 3v3k K 301-332 disorder
       Region 3v3k K 333-416 order
 Evidence X-RAY 3v3k I Reference
       Region 3v3k I 141-300 order
       Region 3v3k I 301-332 disorder
       Region 3v3k I 333-416 order
 Evidence X-RAY 3v3k G Reference
       Region 3v3k G 141-147 disorder
       Region 3v3k G 148-298 order
       Region 3v3k G 299-332 disorder
       Region 3v3k G 333-416 order
 Evidence X-RAY 3v3k E Reference
       Region 3v3k E 141-142 disorder
       Region 3v3k E 143-300 order
       Region 3v3k E 301-331 disorder
       Region 3v3k E 332-416 order
 Evidence X-RAY 3v3k C Reference
       Region 3v3k C 141-147 disorder
       Region 3v3k C 148-300 order
       Region 3v3k C 301-332 disorder
       Region 3v3k C 333-416 order
 Evidence X-RAY 3v3k A Reference
       Region 3v3k A 141-300 order
       Region 3v3k A 301-331 disorder
       Region 3v3k A 332-416 order
Seq 316-321 Hetero dimer : Q13490
 Evidence X-RAY 3d9t D Reference
       Region 3d9t D 316-321 order
 Evidence X-RAY 3d9t C Reference
       Region 3d9t C 316-319 order
       Region 3d9t C 320-321 disorder
Seqphosphorylation
    125-125 Phosphothreonine; by MAPK1
    153-153 Phosphotyrosine; by ABL1
    302-302 Phosphoserine
    307-307 Phosphoserine
    310-310 Phosphoserine
 
Prediction
NeProc
Disorder 1-4,100-145,302-327
Order 5-46,52-99,146-301,328-416
ProS 1-4,100-113,311-318
AlphaFold
Disorder 97-149,242-243,299-310,317-334
Order 1-96,150-241,244-298,311-316,335-416
Pfam Hmmer
PF00619 6-92 2.4e-24
PF00656 161-413 7.9e-88
SEG 6-16
Function
Function in SwissProt
Involved in the activation cascade of caspases responsible for apoptosis execution. Binding of caspase-9 to Apaf-1 leads to activation of the protease which then cleaves and activates caspase-3. Promotes DNA damage-induced apoptosis in a ABL1/c-Abl-dependent manner. Proteolytically cleaves poly(ADP-ribose) polymerase (PARP).
Isoform 2 lacks activity is an dominant-negative inhibitor of caspase-9.