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IID00720
 UniprotQ07817
ProteinBcl-2-like protein 1
GeneBCL2L1
OrganismHomo sapiens
Sequence LLPS PhaSepDB
PhaSePro
LLPSDB
DrLLPS
 Network xml rdf
Structure
Experiment
  :order   disorder   conflict   PDB cluster   ProS   Pfam Domain   SEG
233
 order/disorder by at least rule
     disorder by at least rule
     order by at least rule
 order/disorder by majority rule
Seq 1-26,83-197 Hetero dimer : Q9Y5Z4
 Evidence X-RAY 3r85 D Reference
       Region 3r85 D 1-2 disorder
       Region 3r85 D 3-26 order
       Region 3r85 D 83-197 order
 Evidence X-RAY 3r85 C Reference
       Region 3r85 C 1-2 disorder
       Region 3r85 C 3-26 order
       Region 3r85 C 83-197 order
 Evidence X-RAY 3r85 B Reference
       Region 3r85 B 1-3 disorder
       Region 3r85 B 4-26 order
       Region 3r85 B 83-197 order
 Evidence X-RAY 3r85 A Reference
       Region 3r85 A 1-3 disorder
       Region 3r85 A 4-26 order
       Region 3r85 A 83-197 order
Seq 1-198 Hetero dimer : IID00015Complex
 Evidence NMR 2mej A Reference
       Region 2mej A 1-28 order
       Region 2mej A 29-82 disorder
       Region 2mej A 83-198 order
Seq 1-26,83-209 Hetero tetramer : IID00746Complex
 Evidence X-RAY 2yq7 A Reference
       Region 2yq7 A 1-26 order
       Region 2yq7 A 83-196 order
       Region 2yq7 A 197-209 disorder
 Evidence X-RAY 2yq6 A Reference
       Region 2yq6 A 1-26 order
       Region 2yq6 A 83-196 order
       Region 2yq6 A 197-209 disorder
 Evidence X-RAY 4a1w C Reference
       Region 4a1w C 1-2 disorder
       Region 4a1w C 3-26 order
       Region 4a1w C 83-196 order
       Region 4a1w C 197-209 disorder
 Evidence X-RAY 4a1w B Reference
       Region 4a1w B 1-26 order
       Region 4a1w B 83-197 order
       Region 4a1w B 198-209 disorder
 Evidence X-RAY 4a1w D Reference
       Region 4a1w D 1-26 order
       Region 4a1w D 83-196 order
       Region 4a1w D 197-209 disorder
 Evidence X-RAY 4a1w A Reference
       Region 4a1w A 1-26 order
       Region 4a1w A 83-197 order
       Region 4a1w A 198-209 disorder
Seq 1-26,83-209 Homo tetramer :
 Evidence X-RAY 4c5d B Reference
       Region 4c5d B 1-26 order
       Region 4c5d B 83-198 order
       Region 4c5d B 199-209 disorder
 Evidence X-RAY 4c5d A Reference
       Region 4c5d A 1-26 order
       Region 4c5d A 83-196 order
       Region 4c5d A 197-209 disorder
Seq 1-44,85-209 Hetero dimer : Q92934
 Evidence NMR 1g5j A Reference
       Region 1g5j A 1-44 order
       Region 1g5j A 85-209 order
Seq 1-209 Hetero trimer : Q9BXH1
 Evidence X-RAY 4hnj B Reference
       Region 4hnj B 1-32 order
       Region 4hnj B 33-81 disorder
       Region 4hnj B 82-105 order
       Region 4hnj B 106-120 disorder
       Region 4hnj B 121-131 order
       Region 4hnj B 132-134 disorder
       Region 4hnj B 135-195 order
       Region 4hnj B 196-209 disorder
 Evidence X-RAY 4hnj A Reference
       Region 4hnj A 1-24 order
       Region 4hnj A 25-80 disorder
       Region 4hnj A 81-196 order
       Region 4hnj A 197-209 disorder
Seq 1-209 Hetero dimer : Q16611
 Evidence NMR 1bxl A Reference
       Region 1bxl A 1-44 order
       Region 1bxl A 45-84 disorder
       Region 1bxl A 85-209 order
 Evidence NMR 2lp8 A Reference
       Region 2lp8 A 1-1 high_rmsd
       Region 2lp8 A 1-44 order
       Region 2lp8 A 85-209 order
       Region 2lp8 A 163-169 high_rmsd
Seq 1-44,59-61,85-209 Hetero dimer : Q9BXH1
 Evidence NMR 2m04 A Reference
       Region 2m04 A 1-44 order
       Region 2m04 A 27-40 high_rmsd
       Region 2m04 A 59-61 high_rmsd
       Region 2m04 A 85-209 order
       Region 2m04 A 158-169 high_rmsd
Seq 1-26,83-209 Hetero dimer : IID00746Complex
 Evidence X-RAY 3io8 C Reference
       Region 3io8 C 1-26 order
       Region 3io8 C 83-197 order
       Region 3io8 C 198-209 disorder
 Evidence X-RAY 3io8 A Reference
       Region 3io8 A 1-26 order
       Region 3io8 A 83-108 order
       Region 3io8 A 109-111 disorder
       Region 3io8 A 112-197 order
       Region 3io8 A 198-209 disorder
 Evidence X-RAY 3fdl A Reference
       Region 3fdl A 1-26 order
       Region 3fdl A 83-194 order
       Region 3fdl A 195-209 disorder
 Evidence X-RAY 4a1u A Reference
       Region 4a1u A 1-26 order
       Region 4a1u A 83-206 order
       Region 4a1u A 207-209 disorder
Seq 1-44,85-209 Hetero trimer : Q07812
 Evidence X-RAY 3pl7 A Reference
       Region 3pl7 A 1-2 disorder
       Region 3pl7 A 3-28 order
       Region 3pl7 A 29-41 disorder
       Region 3pl7 A 42-44 order
       Region 3pl7 A 85-196 order
       Region 3pl7 A 197-209 disorder
 Evidence X-RAY 3pl7 B Reference
       Region 3pl7 B 1-3 disorder
       Region 3pl7 B 4-29 order
       Region 3pl7 B 30-41 disorder
       Region 3pl7 B 42-44 order
       Region 3pl7 B 85-196 order
       Region 3pl7 B 197-209 disorder
Seq 1-26,83-209 Hetero tetramer : Q9BXH1
 Evidence X-RAY 4bpk B Reference
       Region 4bpk B 1-1 disorder
       Region 4bpk B 2-26 order
       Region 4bpk B 83-195 order
       Region 4bpk B 196-209 disorder
 Evidence X-RAY 4bpk A Reference
       Region 4bpk A 1-26 order
       Region 4bpk A 83-195 order
       Region 4bpk A 196-209 disorder
Seq 1-44,83-209 Hetero dimer : IID00669Complex
 Evidence NMR 2pon B Reference
       Region 2pon B 1-44 order
       Region 2pon B 32-35 high_rmsd
       Region 2pon B 85-196 order
 Evidence X-RAY 2p1l G Reference
       Region 2p1l G 1-1 disorder
       Region 2p1l G 2-26 order
       Region 2p1l G 83-198 order
       Region 2p1l G 199-209 disorder
 Evidence X-RAY 2p1l E Reference
       Region 2p1l E 1-1 disorder
       Region 2p1l E 2-26 order
       Region 2p1l E 83-198 order
       Region 2p1l E 199-209 disorder
 Evidence X-RAY 2p1l C Reference
       Region 2p1l C 1-1 disorder
       Region 2p1l C 2-26 order
       Region 2p1l C 83-198 order
       Region 2p1l C 199-209 disorder
 Evidence X-RAY 2p1l A Reference
       Region 2p1l A 1-1 disorder
       Region 2p1l A 2-26 order
       Region 2p1l A 83-198 order
       Region 2p1l A 199-209 disorder
Seq 1-211 Monomer :
 Evidence NMR 1ysn A Reference
       Region 1ysn A 1-44 order
       Region 1ysn A 85-209 order
 Evidence NMR 1ysi A Reference
       Region 1ysi A 1-44 order
       Region 1ysi A 85-209 order
 Evidence NMR 1ysg A Reference
       Region 1ysg A 1-44 order
       Region 1ysg A 85-209 order
 Evidence NMR 2o1y A Reference
       Region 2o1y A 1-44 order
       Region 2o1y A 85-209 order
 Evidence NMR 1lxl A Reference
       Region 1lxl A 1-209 order
 Evidence X-RAY 3zlo A Reference
       Region 3zlo A 1-1 disorder
       Region 3zlo A 2-26 order
       Region 3zlo A 27-40 disorder
       Region 3zlo A 41-44 order
       Region 3zlo A 85-196 order
       Region 3zlo A 197-209 disorder
 Evidence X-RAY 3zln A Reference
       Region 3zln A 1-27 order
       Region 3zln A 28-40 disorder
       Region 3zln A 41-44 order
       Region 3zln A 85-196 order
       Region 3zln A 197-209 disorder
 Evidence X-RAY 3zk6 B Reference
       Region 3zk6 B 1-1 disorder
       Region 3zk6 B 2-28 order
       Region 3zk6 B 29-40 disorder
       Region 3zk6 B 81-197 order
       Region 3zk6 B 198-209 disorder
 Evidence X-RAY 3zk6 A Reference
       Region 3zk6 A 1-1 disorder
       Region 3zk6 A 2-28 order
       Region 3zk6 A 29-40 disorder
       Region 3zk6 A 81-197 order
       Region 3zk6 A 198-209 disorder
 Evidence X-RAY 2yxj B Reference
       Region 2yxj B 1-1 disorder
       Region 2yxj B 2-29 order
       Region 2yxj B 30-42 disorder
       Region 2yxj B 43-44 order
       Region 2yxj B 85-196 order
       Region 2yxj B 197-209 disorder
 Evidence X-RAY 2yxj A Reference
       Region 2yxj A 1-3 disorder
       Region 2yxj A 4-25 order
       Region 2yxj A 26-42 disorder
       Region 2yxj A 43-44 order
       Region 2yxj A 85-197 order
       Region 2yxj A 198-209 disorder
 Evidence X-RAY 3spf A Reference
       Region 3spf A 1-25 order
       Region 3spf A 26-41 disorder
       Region 3spf A 42-44 order
       Region 3spf A 85-196 order
       Region 3spf A 198-198 order
       Region 3spf A 199-209 disorder
 Evidence X-RAY 3sp7 A Reference
       Region 3sp7 A 1-29 order
       Region 3sp7 A 30-41 disorder
       Region 3sp7 A 42-44 order
       Region 3sp7 A 85-199 order
       Region 3sp7 A 200-209 disorder
 Evidence X-RAY 1r2i A Reference
       Region 1r2i A 1-27 order
       Region 1r2i A 28-81 disorder
       Region 1r2i A 82-197 order
       Region 1r2i A 198-211 disorder
 Evidence X-RAY 1r2h A Reference
       Region 1r2h A 1-27 order
       Region 1r2h A 28-81 disorder
       Region 1r2h A 82-196 order
       Region 1r2h A 197-211 disorder
 Evidence X-RAY 1r2g A Reference
       Region 1r2g A 1-27 order
       Region 1r2g A 28-80 disorder
       Region 1r2g A 81-196 order
       Region 1r2g A 197-211 disorder
 Evidence X-RAY 1r2e A Reference
       Region 1r2e A 1-1 disorder
       Region 1r2e A 2-27 order
       Region 1r2e A 28-79 disorder
       Region 1r2e A 80-196 order
       Region 1r2e A 197-211 disorder
 Evidence X-RAY 1r2d A Reference
       Region 1r2d A 1-27 order
       Region 1r2d A 28-81 disorder
       Region 1r2d A 82-196 order
       Region 1r2d A 197-211 disorder
 Evidence X-RAY 3qkd B Reference
       Region 3qkd B 1-1 disorder
       Region 3qkd B 2-29 order
       Region 3qkd B 30-42 disorder
       Region 3qkd B 43-44 order
       Region 3qkd B 85-196 order
       Region 3qkd B 197-209 disorder
 Evidence X-RAY 3qkd A Reference
       Region 3qkd A 1-3 disorder
       Region 3qkd A 4-28 order
       Region 3qkd A 29-42 disorder
       Region 3qkd A 43-44 order
       Region 3qkd A 85-197 order
       Region 3qkd A 198-209 disorder
 Evidence NMR 2me9 A Reference
       Region 2me9 A 1-209 order
       Region 2me9 A 21-84 high_rmsd
       Region 2me9 A 103-104 high_rmsd
       Region 2me9 A 117-117 high_rmsd
       Region 2me9 A 193-209 high_rmsd
 Evidence NMR 2me8 A Reference
       Region 2me8 A 1-209 order
       Region 2me8 A 1-1 high_rmsd
       Region 2me8 A 25-84 high_rmsd
       Region 2me8 A 197-209 high_rmsd
 Evidence X-RAY 1maz A Reference
       Region 1maz A 1-27 order
       Region 1maz A 28-80 disorder
       Region 1maz A 81-196 order
       Region 1maz A 197-209 disorder
 Evidence NMR 2m03 A Reference
       Region 2m03 A 1-44 order
       Region 2m03 A 24-41 high_rmsd
       Region 2m03 A 76-78 high_rmsd
       Region 2m03 A 85-209 order
       Region 2m03 A 156-169 high_rmsd
 Evidence NMR 2lpc A Reference
       Region 2lpc A 1-44 order
       Region 2lpc A 85-209 order
 Evidence X-RAY 4ehr A Reference
       Region 4ehr A 1-1 disorder
       Region 4ehr A 2-26 order
       Region 4ehr A 27-42 disorder
       Region 4ehr A 43-44 order
       Region 4ehr A 85-196 order
       Region 4ehr A 197-209 disorder
 Evidence X-RAY 3cva X Reference
       Region 3cva X 1-1 disorder
       Region 3cva X 2-27 order
       Region 3cva X 28-81 disorder
       Region 3cva X 82-196 order
       Region 3cva X 197-211 disorder
Seq 1-211 Homo dimer :
 Evidence X-RAY 3zlr B Reference
       Region 3zlr B 1-3 disorder
       Region 3zlr B 4-26 order
       Region 3zlr B 83-203 order
       Region 3zlr B 204-209 disorder
 Evidence X-RAY 3zlr A Reference
       Region 3zlr A 1-26 order
       Region 3zlr A 83-197 order
       Region 3zlr A 198-209 disorder
 Evidence X-RAY 2yj1 C Reference
       Region 2yj1 C 1-26 order
       Region 2yj1 C 83-196 order
       Region 2yj1 C 197-209 disorder
 Evidence X-RAY 2yj1 A Reference
       Region 2yj1 A 1-26 order
       Region 2yj1 A 83-202 order
       Region 2yj1 A 203-209 disorder
 Evidence X-RAY 3wiz B Reference
       Region 3wiz B 1-2 disorder
       Region 3wiz B 3-27 order
       Region 3wiz B 28-40 disorder
       Region 3wiz B 41-44 order
       Region 3wiz B 85-196 order
       Region 3wiz B 197-209 disorder
 Evidence X-RAY 3wiz A Reference
       Region 3wiz A 1-2 disorder
       Region 3wiz A 3-27 order
       Region 3wiz A 28-40 disorder
       Region 3wiz A 41-44 order
       Region 3wiz A 85-196 order
       Region 3wiz A 197-209 disorder
 Evidence X-RAY 3inq B Reference
       Region 3inq B 1-26 order
       Region 3inq B 83-196 order
       Region 3inq B 197-209 disorder
 Evidence X-RAY 3inq A Reference
       Region 3inq A 1-2 disorder
       Region 3inq A 3-26 order
       Region 3inq A 83-196 order
       Region 3inq A 197-209 disorder
 Evidence X-RAY 3fdm C Reference
       Region 3fdm C 1-1 disorder
       Region 3fdm C 2-26 order
       Region 3fdm C 83-198 order
       Region 3fdm C 199-209 disorder
 Evidence X-RAY 3fdm B Reference
       Region 3fdm B 1-26 order
       Region 3fdm B 83-197 order
       Region 3fdm B 198-209 disorder
 Evidence X-RAY 3fdm A Reference
       Region 3fdm A 1-26 order
       Region 3fdm A 83-198 order
       Region 3fdm A 199-209 disorder
 Evidence X-RAY 4c52 B Reference
       Region 4c52 B 1-26 order
       Region 4c52 B 83-198 order
       Region 4c52 B 199-209 disorder
 Evidence X-RAY 4c52 A Reference
       Region 4c52 A 1-26 order
       Region 4c52 A 83-196 order
       Region 4c52 A 197-209 disorder
 Evidence X-RAY 2b48 A Reference
       Region 2b48 A 1-24 order
       Region 2b48 A 25-81 disorder
       Region 2b48 A 82-200 order
       Region 2b48 A 201-211 disorder
Seq 2-20,83-196 Monomer :
 Evidence NMR 2o2n A Reference
       Region 2o2n A 2-20 order
       Region 2o2n A 83-196 order
Seq 2-20,83-196 Monomer :
 Evidence NMR 2o2m A Reference
       Region 2o2m A 2-20 order
       Region 2o2m A 83-196 order
Seqdisorder 29-44
 Evidence X-RAY 4aq3 A Reference
       Region 4aq3 A 29-44 disorder
Seqdisorder 29-44
 Evidence X-RAY 4aq3 C Reference
       Region 4aq3 C 29-44 disorder
Seq 29-44 Homo hexamer : IID00707Complex
 Evidence X-RAY 4aq3 F Reference
       Region 4aq3 F 29-44 disorder
 Evidence X-RAY 4aq3 D Reference
       Region 4aq3 D 29-42 disorder
       Region 4aq3 D 43-44 order
Seq 29-44 Monomer : IID00707Complex
 Evidence X-RAY 4ieh A Reference
       Region 4ieh A 29-42 disorder
       Region 4ieh A 43-44 order
Seqdisorder 29-44
 Evidence X-RAY 4aq3 E Reference
       Region 4aq3 E 29-44 disorder
Seqdisorder 29-44
 Evidence X-RAY 4aq3 B Reference
       Region 4aq3 B 29-44 disorder
Seqphosphorylation
    62-62 Phosphoserine; by CDK1
    49-49 Phosphoserine; by PLK3
 
Prediction
NeProc
Disorder 28-82,201-212,231-233
Order 1-27,83-200,213-230
ProS 31-36,53-65,207-212,231-233
AlphaFold
Disorder 1-1,29-81,105-105,108-108,197-233
Order 2-28,82-104,106-107,109-196
Pfam Hmmer
PF02180 1-27 2.5e-14
PF00452 90-188 4.3e-59
Function
Function in SwissProt
Potent inhibitor of cell death. Inhibits activation of caspases. Appears to regulate cell death by blocking the voltage-dependent anion channel (VDAC) by binding to it and preventing the release of the caspase activator, CYC1, from the mitochondrial membrane. Also acts as a regulator of G2 checkpoint and progression to cytokinesis during mitosis.
Isoform Bcl-X(L) also regulates presynaptic plasticity, including neurotransmitter release and recovery, number of axonal mitochondria as well as size and number of synaptic vesicle clusters. During synaptic stimulation, increases ATP availability from mitochondria through regulation of mitochondrial membrane ATP synthase F(1)F(0) activity and regulates endocytic vesicle retrieval in hippocampal neurons through association with DMN1L and stimulation of its GTPase activity in synaptic vesicles. May attenuate inflammation impairing NLRP1-inflammasome activation, hence CASP1 activation and IL1B release (PubMed
17418785).
Isoform Bcl-X(S) promotes apoptosis.
Biological Process
See also
Diagram with PDB data
BECN1/BCL2L1Solution structure of the Bcl-xL/Beclin-1 complex