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IID00724
 UniprotQ14527
ProteinHelicase-like transcription factor
GeneHLTF
OrganismHomo sapiens
Sequence LLPS PhaSepDB
PhaSePro
LLPSDB
DrLLPS Network xml rdf
Structure
Experiment
  :order   disorder   conflict   PDB cluster   ProS   Pfam Domain   SEG
1009
 order/disorder by at least rule
     disorder by at least rule
     order by at least rule
 order/disorder by majority rule
Seq 26-39 Hetero tetramer : IID00700Complex,P60903
 Evidence X-RAY 4hrh D Reference
       Region 4hrh D 26-30 disorder
       Region 4hrh D 31-39 order
 Evidence X-RAY 4hrh C Reference
       Region 4hrh C 26-30 disorder
       Region 4hrh C 31-39 order
Seq 26-39 Hetero dimer : IID00700Complex,P60903
 Evidence X-RAY 4hrh C Reference
       Region 4hrh C 26-30 disorder
       Region 4hrh C 31-39 order
Seq 26-39 Hetero dimer : IID00700Complex,P60903
 Evidence X-RAY 4hrh D Reference
       Region 4hrh D 26-30 disorder
       Region 4hrh D 31-39 order
Seq 26-39 Hetero hexamer : P07356,P60903
 Evidence X-RAY 4hre L Reference
       Region 4hre L 26-30 disorder
       Region 4hre L 31-39 order
 Evidence X-RAY 4hre K Reference
       Region 4hre K 26-30 disorder
       Region 4hre K 31-39 order
Seq 26-39 Hetero hexamer : P07356,P60903
 Evidence X-RAY 4hre H Reference
       Region 4hre H 26-30 disorder
       Region 4hre H 31-39 order
 Evidence X-RAY 4hre G Reference
       Region 4hre G 26-30 disorder
       Region 4hre G 31-39 order
Seq 51-174 Monomer :
 Evidence X-RAY 4xzg I Reference
       Region 4xzg I 57-173 order
       Region 4xzg I 174-174 disorder
 Evidence X-RAY 4xzg H Reference
       Region 4xzg H 57-174 order
 Evidence X-RAY 4xzg G Reference
       Region 4xzg G 57-173 order
       Region 4xzg G 174-174 disorder
 Evidence X-RAY 4xzg F Reference
       Region 4xzg F 57-173 order
       Region 4xzg F 174-174 disorder
 Evidence X-RAY 4xzg E Reference
       Region 4xzg E 57-173 order
       Region 4xzg E 174-174 disorder
 Evidence X-RAY 4xzg D Reference
       Region 4xzg D 57-173 order
       Region 4xzg D 174-174 disorder
 Evidence X-RAY 4xzg C Reference
       Region 4xzg C 57-173 order
       Region 4xzg C 174-174 disorder
 Evidence X-RAY 4xzg B Reference
       Region 4xzg B 57-173 order
       Region 4xzg B 174-174 disorder
 Evidence X-RAY 4xzg A Reference
       Region 4xzg A 57-173 order
       Region 4xzg A 174-174 disorder
 Evidence X-RAY 4xzf A Reference
       Region 4xzf A 58-173 order
       Region 4xzf A 174-174 disorder
 Evidence NMR 2mzn A Reference
       Region 2mzn A 51-171 order
 Evidence NMR 5k5f A Reference
       Region 5k5f A 51-171 order
Seq 55-175 Homo dimer :
 Evidence X-RAY 5bnh D Reference
       Region 5bnh D 55-175 order
 Evidence X-RAY 5bnh A Reference
       Region 5bnh A 55-175 order
Seq 55-180 Homo tetramer :
 Evidence X-RAY 4s0n D Reference
       Region 4s0n D 55-176 order
       Region 4s0n D 177-180 disorder
 Evidence X-RAY 4s0n C Reference
       Region 4s0n C 55-174 order
       Region 4s0n C 175-180 disorder
 Evidence X-RAY 4s0n B Reference
       Region 4s0n B 55-55 disorder
       Region 4s0n B 56-180 order
 Evidence X-RAY 4s0n A Reference
       Region 4s0n A 55-55 disorder
       Region 4s0n A 56-177 order
       Region 4s0n A 178-180 disorder
Seqphosphorylation
    195-195 Phosphotyrosine; by JAK2
    397-397 Phosphoserine
    398-398 Phosphoserine
    400-400 Phosphoserine
    736-736 Phosphothreonine
 
Prediction
NeProc
Disorder 1-53,166-209,224-232,322-474,816-827,988-1009
Order 54-165,210-223,233-321,475-727,740-752,757-815,828-987
ProS 1-13,21-26,37-46,166-172,188-194,322-425,431-448,460-464,992-1009
AlphaFold
Disorder 1-56,138-138,174-215,218-227,322-473,541-542,588-592,650-653,655-657,703-703,723-741,746-760,763-768,812-828,887-887,915-918,980-995
Order 57-137,139-173,216-217,228-321,474-540,543-587,593-649,654-654,658-702,704-722,742-745,761-762,769-811,829-886,888-914,919-979,996-1009
Pfam Hmmer
PF00176 243-722 1.1e-64
PF00097 760-800 5.3e-05
PF00271 870-950 2.3e-19
SEG 213-226 ,395-407 ,740-752
Function
Function in SwissProt
Has both helicase and E3 ubiquitin ligase activities. Possesses intrinsic ATP-dependent nucleosome-remodeling activity; This activity may be required for transcriptional activation or repression of specific target promoters (By similarity). These may include the SERPINE1 and HIV-1 promoters and the SV40 enhancer, to which this protein can bind directly. Plays a role in error-free postreplication repair (PRR) of damaged DNA and maintains genomic stability through acting as a ubiquitin ligase for 'Lys-63'-linked polyubiquitination of chromatin-bound PCNA.
Biological Process
Diagram with PDB data
HLTF/S100A10/ANXA2Crystal Structure of p11-Annexin A2(N-terminal) Fusion Protein in Complex with SMARCA3 Peptide