Structure
atLeast majority ProS Experiment
:order disorder conflict PDB cluster ProS Pfam Domain SEG1009
order/disorder by at least rule
disorder by at least rule
order/disorder by majority rule
Seq 26-39 Hetero tetramer : IID00700 Complex ,
P60903
Region 4hrh D 26-30 disorder
Region 4hrh D 31-39 order
Region 4hrh C 26-30 disorder
Region 4hrh C 31-39 order
Seq 26-39 Hetero dimer : IID00700 Complex ,
P60903
Region 4hrh C 26-30 disorder
Region 4hrh C 31-39 order
Seq 26-39 Hetero dimer : IID00700 Complex ,
P60903
Region 4hrh D 26-30 disorder
Region 4hrh D 31-39 order
Region 4hre L 26-30 disorder
Region 4hre L 31-39 order
Region 4hre K 26-30 disorder
Region 4hre K 31-39 order
Region 4hre H 26-30 disorder
Region 4hre H 31-39 order
Region 4hre G 26-30 disorder
Region 4hre G 31-39 order
Region 4xzg I 57-173 order
Region 4xzg I 174-174 disorder
Region 4xzg H 57-174 order
Region 4xzg G 57-173 order
Region 4xzg G 174-174 disorder
Region 4xzg F 57-173 order
Region 4xzg F 174-174 disorder
Region 4xzg E 57-173 order
Region 4xzg E 174-174 disorder
Region 4xzg D 57-173 order
Region 4xzg D 174-174 disorder
Region 4xzg C 57-173 order
Region 4xzg C 174-174 disorder
Region 4xzg B 57-173 order
Region 4xzg B 174-174 disorder
Region 4xzg A 57-173 order
Region 4xzg A 174-174 disorder
Region 4xzf A 58-173 order
Region 4xzf A 174-174 disorder
Region 2mzn A 51-171 order
Region 5k5f A 51-171 order
Region 5bnh D 55-175 order
Region 5bnh A 55-175 order
Seq 55-180 Homo tetramer :
Region 4s0n D 55-176 order
Region 4s0n D 177-180 disorder
Region 4s0n C 55-174 order
Region 4s0n C 175-180 disorder
Region 4s0n B 55-55 disorder
Region 4s0n B 56-180 order
Region 4s0n A 55-55 disorder
Region 4s0n A 56-177 order
Region 4s0n A 178-180 disorder
195-195 Phosphotyrosine; by JAK2
Prediction
Function
Function in SwissProt
Has both helicase and E3 ubiquitin ligase activities. Possesses intrinsic ATP-dependent nucleosome-remodeling activity; This activity may be required for transcriptional activation or repression of specific target promoters (By similarity). These may include the SERPINE1 and HIV-1 promoters and the SV40 enhancer, to which this protein can bind directly. Plays a role in error-free postreplication repair (PRR) of damaged DNA and maintains genomic stability through acting as a ubiquitin ligase for 'Lys-63'-linked polyubiquitination of chromatin-bound PCNA.
Biological Process
Diagram with PDB data HLTF/S100A10/ANXA2 Crystal Structure of p11-Annexin A2(N-terminal) Fusion Protein in Complex with SMARCA3 Peptide
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