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IID00729
 UniprotQ53EL6
ProteinProgrammed cell death protein 4
GenePDCD4
OrganismHomo sapiens
Sequence LLPS PhaSepDB
PhaSePro
LLPSDB
DrLLPS
 Network xml rdf
Structure
Experiment
  :order   disorder   conflict   PDB cluster   ProS   Pfam Domain   SEG
469
 order/disorder by at least rule
     disorder by at least rule
     order by at least rule
 order/disorder by majority rule
Seq 157-318 Hetero dimer : IID50333Complex
 Evidence NMR 2kzt A Reference
       Region 2kzt A 157-318 order
Seq 157-320 Monomer :
 Evidence X-RAY 2rg8 B Reference
       Region 2rg8 B 157-305 order
       Region 2rg8 B 306-320 disorder
 Evidence X-RAY 2rg8 A Reference
       Region 2rg8 A 157-305 order
       Region 2rg8 A 306-320 disorder
Seq 157-469 Monomer :
 Evidence X-RAY 3eij B Reference
       Region 3eij B 157-283 order
       Region 3eij B 284-286 disorder
       Region 3eij B 287-306 order
       Region 3eij B 307-323 disorder
       Region 3eij B 324-450 order
       Region 3eij B 451-469 disorder
 Evidence X-RAY 3eij A Reference
       Region 3eij A 157-283 order
       Region 3eij A 284-286 disorder
       Region 3eij A 287-306 order
       Region 3eij A 307-323 disorder
       Region 3eij A 324-450 order
       Region 3eij A 451-469 disorder
Seq 163-469 Hetero trimer : P60842
 Evidence X-RAY 2zu6 E Reference
       Region 2zu6 E 163-306 order
       Region 2zu6 E 307-312 disorder
       Region 2zu6 E 313-450 order
       Region 2zu6 E 451-469 disorder
Seq 163-469 Hetero trimer : P60842
 Evidence X-RAY 2zu6 B Reference
       Region 2zu6 B 163-306 order
       Region 2zu6 B 307-310 disorder
       Region 2zu6 B 311-450 order
       Region 2zu6 B 451-469 disorder
Seq 327-450 Monomer :
 Evidence NMR 2ggf A Reference
       Region 2ggf A 327-450 order
Seqphosphorylation
    94-94 Phosphoserine
    457-457 Phosphoserine; by PKB
    317-317 Phosphoserine
    313-313 Phosphoserine
    152-152 Phosphotyrosine
    80-80 Phosphoserine
    78-78 Phosphoserine
    76-76 Phosphoserine
    71-71 Phosphoserine
    68-68 Phosphoserine
    67-67 Phosphoserine; by PKB and RPS6KB1
    25-25 Phosphoserine
Seqacetylation
    1-1 N-acetylmethionine
 
Prediction
NeProc
Disorder 1-143,461-469
Order 144-460
ProS 1-24,38-45,53-61,107-113,121-129,135-143,461-469
AlphaFold
Disorder 1-135,147-156,307-313,451-469
Order 136-146,157-306,314-450
Pfam Hmmer
PF02847 164-275 1e-43
PF02847 327-440 7.9e-48
SEG 67-83 ,96-122 ,316-323
Function
Function in SwissProt
Inhibits translation initiation and cap-dependent translation. May excert its function by hindering the interaction between EIF4A1 and EIF4G. Inhibits the helicase activity of EIF4A. Modulates the activation of JUN kinase. Down-regulates the expression of MAP4K1, thus inhibiting events important in driving invasion, namely, MAPK85 activation and consequent JUN-dependent transcription. May play a role in apoptosis. Tumor suppressor. Inhibits tumor promoter-induced neoplastic transformation. Binds RNA (By similarity).