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IID00731
 UniprotQ86YP4
ProteinTranscriptional repressor p66-alpha
GeneGATAD2A
OrganismHomo sapiens
Sequence LLPS PhaSepDB
PhaSePro
LLPSDB
DrLLPS
 Network xml rdf
Structure
Experiment
  :order   disorder   conflict   PDB cluster   ProS   Pfam Domain   SEG
633
 order/disorder by at least rule
     disorder by at least rule
     order by at least rule
 order/disorder by majority rule
Seq 137-178 Hetero dimer : IID00739Complex
 Evidence NMR 2l2l A Reference
       Region 2l2l A 137-178 order
Seqphosphorylation
    548-548 Phosphoserine
    556-556 Phosphoserine
    598-598 Phosphoserine
    546-546 Phosphoserine
    20-20 Phosphothreonine
    49-49 Phosphothreonine
    100-100 Phosphoserine
    107-107 Phosphoserine
    113-113 Phosphoserine
    114-114 Phosphoserine
    137-137 Phosphoserine
    189-189 Phosphothreonine
    275-275 Phosphoserine
    340-340 Phosphoserine
    343-343 Phosphoserine
    512-512 Phosphoserine
 
Prediction
NeProc
Disorder 1-144,173-393,402-633
Order 145-172,394-401
ProS 1-17,22-35,55-61,86-109,114-129,139-144,361-365,372-377,383-393,410-441,458-464,586-591,610-621,629-633
AlphaFold
Disorder 1-6,9-9,11-11,15-82,84-134,174-339,366-368,370-377,401-412,480-607,623-633
Order 7-8,10-10,12-14,83-83,135-173,340-365,369-369,378-400,413-479,608-622
Pfam Hmmer
PF00320 417-451 0.00023
SEG 148-165 ,280-293 ,326-356 ,364-371 ,466-479 ,482-494
Function
Function in SwissProt
Transcriptional repressor. Enhances MBD2-mediated repression. Efficient repression requires the presence of GATAD2B.
Biological Process
See also
Diagram with PDB data
MTA1/HDAC1The structure of HDAC1 in complex with the dimeric ELM2-SANT domain of MTA1 from the NuRD complex