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IID00738
UniprotQ9NQI0
ProteinProbable ATP-dependent RNA helicase DDX4
GeneDDX4
OrganismHomo sapiens
Sequence LLPS PhaSepDB
PhaSePro
LLPSDB
DrLLPS
xml
Structure
Experiment
  :order   disorder   conflict   PDB cluster   ProS   Pfam Domain   SEG
724
 order/disorder by at least rule
     disorder by at least rule
     order by at least rule
 order/disorder by majority rule
Seqdisorder 1-236
 Evidence NMR This region is described to be disordered in free state. (PubMed=25747659) Reference
       Region 1-236 disorder
Seqphosphorylation
    722-722 Phosphoserine
    226-226 Phosphoserine
    222-222 Phosphoserine
 
Prediction
NeProc
Disorder 1-245,678-724
Order 246-356,361-677
ProS 1-37,44-245,690-708,721-724
AlphaFold
Disorder 1-242,261-265,356-360,509-509,600-601,603-603,679-696,699-724
Order 243-260,266-355,361-508,510-599,602-602,604-678,697-698
Pfam Hmmer
PF00270 312-491 2.5e-70
PF00271 559-635 3e-35
SEG 146-164 ,195-210 ,248-256
Function
Function in SwissProt
ATP-dependent RNA helicase required during spermatogenesis (PubMed:10920202, PubMed:21034600). Required to repress transposable elements and preventing their mobilization, which is essential for the germline integrity (By similarity). Acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and governs the methylation and subsequent repression of transposons (By similarity). Involved in the secondary piRNAs metabolic process, the production of piRNAs in fetal male germ cells through a ping-pong amplification cycle (By similarity). Required for PIWIL2 slicing-triggered piRNA biogenesis: helicase activity enables utilization of one of the slice cleavage fragments generated by PIWIL2 and processing these pre-piRNAs into piRNAs (By similarity).