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IID00739
 UniprotQ9UBB5
ProteinMethyl-CpG-binding domain protein 2
GeneMBD2
OrganismHomo sapiens
Sequence LLPS PhaSepDB
PhaSePro
LLPSDB
DrLLPS
 Network xml rdf
Structure
Experiment
  :order   disorder   conflict   PDB cluster   ProS   Pfam Domain   SEG
411
 order/disorder by at least rule
     disorder by at least rule
     order by at least rule
 order/disorder by majority rule
Seq 143-220 Homo dimer :
 Evidence X-RAY 6c1a A Reference
       Region 6c1a A 143-146 disorder
       Region 6c1a A 147-214 order
       Region 6c1a A 215-220 disorder
 Evidence X-RAY 6c1a B Reference
       Region 6c1a B 143-147 disorder
       Region 6c1a B 148-214 order
       Region 6c1a B 215-220 disorder
 Evidence X-RAY 6c1a E Reference
       Region 6c1a E 143-147 disorder
       Region 6c1a E 148-215 order
       Region 6c1a E 216-220 disorder
 Evidence X-RAY 6c1a F Reference
       Region 6c1a F 143-147 disorder
       Region 6c1a F 148-215 order
       Region 6c1a F 216-220 disorder
 Evidence X-RAY 6c1t A Reference
       Region 6c1t A 143-147 disorder
       Region 6c1t A 148-214 order
       Region 6c1t A 215-220 disorder
 Evidence X-RAY 6c1t D Reference
       Region 6c1t D 143-148 disorder
       Region 6c1t D 149-214 order
       Region 6c1t D 215-220 disorder
 Evidence X-RAY 6c1u A Reference
       Region 6c1u A 143-146 disorder
       Region 6c1u A 147-214 order
       Region 6c1u A 215-220 disorder
 Evidence X-RAY 6c1u B Reference
       Region 6c1u B 143-147 disorder
       Region 6c1u B 148-215 order
       Region 6c1u B 216-220 disorder
 Evidence X-RAY 6c1u E Reference
       Region 6c1u E 143-146 disorder
       Region 6c1u E 147-215 order
       Region 6c1u E 216-220 disorder
 Evidence X-RAY 6c1u F Reference
       Region 6c1u F 143-146 disorder
       Region 6c1u F 147-214 order
       Region 6c1u F 215-220 disorder
 Evidence X-RAY 6c1v A Reference
       Region 6c1v A 143-147 disorder
       Region 6c1v A 148-215 order
       Region 6c1v A 216-220 disorder
 Evidence X-RAY 6c1v B Reference
       Region 6c1v B 143-146 disorder
       Region 6c1v B 147-214 order
       Region 6c1v B 215-220 disorder
 Evidence X-RAY 6c1v E Reference
       Region 6c1v E 143-147 disorder
       Region 6c1v E 148-215 order
       Region 6c1v E 216-220 disorder
 Evidence X-RAY 6c1v F Reference
       Region 6c1v F 143-147 disorder
       Region 6c1v F 148-215 order
       Region 6c1v F 216-220 disorder
Seqdisorder 238-356
 Evidence NMR¸ CD Reference
       Region 238-356 disorder
Seq 360-393 Hetero dimer : IID00731Complex
 Evidence NMR 2l2l B Reference
       Region 2l2l B 360-393 order
       Region 2l2l B 360-360 high_rmsd
       Region 2l2l B 391-393 high_rmsd
Seqphosphorylation
    407-407 Phosphoserine
    181-181 Phosphoserine
 
Prediction
NeProc
Disorder 1-148,210-239,244-281,308-345,393-411
Order 149-209,240-243,282-307,346-392
ProS 1-14,24-36,46-60,105-115,140-148,210-216,223-239,244-273,308-330,338-345,393-400
AlphaFold
Disorder 1-147,216-256,258-258,263-263,265-277,400-411
Order 148-215,257-257,259-262,264-264,278-399
Pfam Hmmer
PF01429 145-216 1.9e-31
SEG 15-31 ,48-124 ,130-143
Function
Function in SwissProt
Binds CpG islands in promoters where the DNA is methylated at position 5 of cytosine within CpG dinucleotides. Binds hemimethylated DNA as well. Recruits histone deacetylases and DNA methyltransferases. Acts as transcriptional repressor and plays a role in gene silencing. Functions as a scaffold protein, targeting GATAD2A and GATAD2B to chromatin to promote repression. May enhance the activation of some unmethylated cAMP-responsive promoters.
Biological Process
See also
Diagram with PDB data
MTA1/HDAC1The structure of HDAC1 in complex with the dimeric ELM2-SANT domain of MTA1 from the NuRD complex