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IID00740
 UniprotQ9ULJ6
ProteinZinc finger MIZ domain-containing protein 1
GeneZMIZ1
OrganismHomo sapiens
Sequence LLPS PhaSepDB
PhaSePro
LLPSDB
DrLLPS
 xml
Structure
Experiment
  :order   disorder   conflict   PDB cluster   ProS   Pfam Domain   SEG
1067
 order/disorder by at least rule
     disorder by at least rule
     order by at least rule
 order/disorder by majority rule
Seq 1-118 Monomer :
 Evidence X-RAY 5aiz A Reference
       Region 5aiz A 1-2 disorder
       Region 5aiz A 3-112 order
       Region 5aiz A 113-118 disorder
 
Prediction
NeProc
Disorder 1-6,111-558,716-728,826-1055
Order 7-110,559-715,729-825,1056-1067
ProS 140-150,168-173,264-268,411-421,483-494,518-522,541-546,554-558,840-850,900-904,910-914,976-980,1004-1010,1027-1055
AlphaFold
Disorder 1-1,114-560,715-732,775-776,828-844,866-1067
Order 2-113,561-714,733-774,777-827,845-865
Pfam Hmmer
PF02891 738-790 1.5e-38
SEG 123-142 ,183-201 ,244-258 ,280-305 ,451-462 ,479-504 ,510-525 ,866-880 ,972-1004 ,1040-1063
Function
Function in SwissProt
Acts as transcriptional coactivator. Increases ligand-dependent transcriptional activity of AR and promotes AR sumoylation. The stimulation of AR activity is dependent upon sumoylation (PubMed:14609956, PubMed:26522984). Also functions as a transcriptional coactivator in the TGF-beta signaling pathway by increasing the activity of the SMAD3/SMAD4 transcriptional complex (PubMed:16777850). Involved in transcriptional activation of a subset of NOTCH1 target genes including MYC. Involved in thymocyte and T cell development (By similarity). Involved in the regulation of postmitotic positioning of pyramidal neurons in the developing cerebral cortex (PubMed:30639322).