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IID00742
 UniprotQ9Y2N7
ProteinHypoxia-inducible factor 3-alpha
GeneHIF3A
OrganismHomo sapiens
Sequence LLPS PhaSepDB
PhaSePro
LLPSDB
DrLLPS xml
Structure
Experiment
  :order   disorder   conflict   PDB cluster   ProS   Pfam Domain   SEG
669
 order/disorder by at least rule
     disorder by at least rule
     order by at least rule
 order/disorder by majority rule
Seq 237-347 Monomer :
 Evidence X-RAY 4wn5 A Reference
       Region 4wn5 A 237-324 order
       Region 4wn5 A 325-325 disorder
       Region 4wn5 A 326-343 order
       Region 4wn5 A 344-347 disorder
 Evidence X-RAY 4wn5 B Reference
       Region 4wn5 B 237-237 disorder
       Region 4wn5 B 238-342 order
       Region 4wn5 B 343-347 disorder
 
Prediction
NeProc
Disorder 1-26,78-83,142-156,205-213,351-669
Order 27-77,84-141,157-199,214-350
ProS 13-26,142-149,351-357,416-419,441-452,460-465,482-508,540-545,564-570,591-594,600-616,628-651,657-669
AlphaFold
Disorder 1-9,74-84,86-86,148-158,201-213,233-235,325-330,357-386,392-397,424-669
Order 10-73,85-85,87-147,159-200,214-232,236-324,331-356,387-391,398-423
Pfam Hmmer
PF08447 251-344 8.4e-19
SEG 475-487 ,530-541 ,550-564 ,603-614 ,629-646
Function
Function in SwissProt
Acts as a transcriptional regulator in adaptive response to low oxygen tension. Acts as a regulator of hypoxia-inducible gene expression (PubMed:11573933, PubMed:16126907, PubMed:19694616, PubMed:20416395, PubMed:21069422). Functions as an inhibitor of angiogenesis in hypoxic cells of the cornea. Plays a role in the development of the cardiorespiratory system. May also be involved in apoptosis (By similarity).
Isoform 2
Attenuates the ability of transcription factor HIF1A to bind to hypoxia-responsive elements (HRE) located within the enhancer/promoter of hypoxia-inducible target genes and hence inhibits HRE-driven transcriptional activation. Also inhibits hypoxia-inducible ARNT-mediated gene expression.
Isoform 3
Attenuates the ability of transcription factor HIF1A to bind to hypoxia-responsive elements (HRE) located within the enhancer/promoter of hypoxia-inducible target genes and hence inhibits HRE-driven transcriptional activation.
Isoform 4
Attenuates the ability of transcription factor HIF1A and EPAS1/HIF2A to bind to hypoxia-responsive elements (HRE) located within the enhancer/promoter of hypoxia-inducible target genes and hence inhibits HRE-driven transcriptional activation (PubMed:16126907, PubMed:17998805, PubMed:19694616, PubMed:20416395). May act as a tumor suppressor and inhibits malignant cell transformation (PubMed:17998805).
Isoform 5
Attenuates the ability of transcription factor HIF1A to bind to hypoxia-responsive elements (HRE) located within the enhancer/promoter of hypoxia-inducible target genes and hence inhibits HRE-driven transcriptional activation.