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IID00745
 UniprotQ9Y6K9
ProteinNF-kappa-B essential modulator
GeneIKBKG
OrganismHomo sapiens
Sequence LLPS PhaSepDB
PhaSePro
LLPSDB
DrLLPS Network xml rdf
Structure
Experiment
  :order   disorder   conflict   PDB cluster   ProS   Pfam Domain   SEG
419
 order/disorder by at least rule
     disorder by at least rule
     order by at least rule
 order/disorder by majority rule
Seqdisorder 1-111
 Evidence NMR Reference
       Region 1-111 disorder
Seq 44-111 Hetero dimer : IID00525Complex,IID00526Complex
 Evidence X-RAY 3brt D Reference
       Region 3brt D 44-48 disorder
       Region 3brt D 49-110 order
       Region 3brt D 111-111 disorder
Seq 44-111 Hetero dimer : IID00525Complex,IID00526Complex
 Evidence X-RAY 3brt D Reference
       Region 3brt D 44-48 disorder
       Region 3brt D 49-110 order
       Region 3brt D 111-111 disorder
Seq 44-111 Hetero tetramer : IID00525Complex
 Evidence X-RAY 3brv D Reference
       Region 3brv D 44-48 disorder
       Region 3brv D 49-110 order
       Region 3brv D 111-111 disorder
 Evidence X-RAY 3brv B Reference
       Region 3brv B 44-48 disorder
       Region 3brv B 49-109 order
       Region 3brv B 110-111 disorder
Seq 44-111 Hetero dimer : IID00525Complex,IID00526Complex
 Evidence X-RAY 3brt B Reference
       Region 3brt B 44-48 disorder
       Region 3brt B 49-109 order
       Region 3brt B 110-111 disorder
Seq 44-111 Hetero dimer : IID00525Complex,IID00526Complex
 Evidence X-RAY 3brt B Reference
       Region 3brt B 44-48 disorder
       Region 3brt B 49-109 order
       Region 3brt B 110-111 disorder
Seq 150-272 Hetero tetramer : Q76RF1
 Evidence X-RAY 3cl3 E Reference
       Region 3cl3 E 150-195 disorder
       Region 3cl3 E 196-253 order
       Region 3cl3 E 254-272 disorder
 Evidence X-RAY 3cl3 D Reference
       Region 3cl3 D 150-192 disorder
       Region 3cl3 D 193-251 order
       Region 3cl3 D 252-272 disorder
Seq 246-337 Homo dimer :
 Evidence X-RAY 3fx0 B Reference
       Region 3fx0 B 246-262 disorder
       Region 3fx0 B 263-333 order
       Region 3fx0 B 334-337 disorder
 Evidence X-RAY 3fx0 A Reference
       Region 3fx0 A 246-266 disorder
       Region 3fx0 A 267-329 order
       Region 3fx0 A 330-337 disorder
Seq 394-419 Monomer :
 Evidence NMR 2jvx A Reference
       Region 2jvx A 394-419 order
 Evidence NMR 2jvy A Reference
       Region 2jvy A 394-419 order
SeqProS verified 49-109 Hetero tetramer : IID00525Complex
       Region 3brv B 49-109 order
       Region 3brv D 49-110 order
       Region 1-111 disorder
Seqphosphorylation
    31-31 Phosphoserine; by IKKB
    43-43 Phosphoserine; by IKKB
    68-68 Phosphoserine
    85-85 Phosphoserine; by ATM
    376-376 Phosphoserine; by IKKB
    387-387 Phosphoserine
 
Prediction
NeProc
Disorder 1-50,202-212,248-252,295-304,354-391
Order 51-201,213-247,253-294,305-353,392-419
ProS 1-16,48-50,202-212,248-252,295-304,354-354
AlphaFold
Disorder 1-49,248-260,359-393,419-419
Order 50-247,261-358,394-418
SEG 259-280 ,313-339 ,364-393
Function
Function in SwissProt
Regulatory subunit of the IKK core complex which phosphorylates inhibitors of NF-kappa-B thus leading to the dissociation of the inhibitor/NF-kappa-B complex and ultimately the degradation of the inhibitor (PubMed:9751060, PubMed:14695475, PubMed:20724660). Its binding to scaffolding polyubiquitin plays a key role in IKK activation by multiple signaling receptor pathways (PubMed:16547522, PubMed:18287044, PubMed:19033441, PubMed:21606507, PubMed:27777308, PubMed:19185524). Can recognize and bind both 'Lys-63'-linked and linear polyubiquitin upon cell stimulation, with a much highr affinity for linear polyubiquitin (PubMed:16547522, PubMed:18287044, PubMed:27777308, PubMed:19033441, PubMed:21606507, PubMed:19185524). Could be implicated in NF-kappa-B-mediated protection from cytokine toxicity. Essential for viral activation of IRF3 (PubMed:19854139). Involved in TLR3- and IFIH1-mediated antiviral innate response; this function requires 'Lys-27'-linked polyubiquitination (PubMed:20724660).
(Microbial infection) Also considered to be a mediator for HTLV-1 Tax oncoprotein activation of NF-kappa-B.