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IID00746
 UniprotO43521
ProteinBcl-2-like protein 11
GeneBCL2L11
OrganismHomo sapiens
Sequence LLPS PhaSepDB
PhaSePro
LLPSDB
DrLLPS
 Network xml rdf
Structure
Experiment
  :order   disorder   conflict   PDB cluster   ProS   Pfam Domain   SEG
198
 order/disorder by at least rule
     disorder by at least rule
     order by at least rule
 order/disorder by majority rule
Seq 108-116 Hetero tetramer : IID50322Complex
 Evidence NMR 1f95 D Reference
       Region 1f95 D 108-116 order
 Evidence NMR 1f95 C Reference
       Region 1f95 C 108-116 order
Seq 141-160 Hetero tetramer : Q07812
 Evidence X-RAY 4zih B Reference
       Region 4zih B 141-143 disorder
       Region 4zih B 144-159 order
       Region 4zih B 160-160 disorder
 Evidence X-RAY 4zif B Reference
       Region 4zif B 141-143 disorder
       Region 4zif B 144-159 order
       Region 4zif B 160-160 disorder
Seq 141-165 Hetero dimer : Q16611
 Evidence X-RAY 5vwv B Reference
       Region 5vwv B 141-165 order
Seq 141-165 Hetero dimer : Q16548
 Evidence X-RAY 2vm6 B Reference
       Region 2vm6 B 141-165 order
Seq 141-166 Hetero dimer : P97287,Q07820
 Evidence X-RAY 3d7v B Reference
       Region 3d7v B 141-142 disorder
       Region 3d7v B 143-165 order
       Region 3d7v B 166-166 disorder
Seq 141-166 Hetero dimer : IID00720Complex
 Evidence X-RAY 4qvf B Reference
       Region 4qvf B 141-143 disorder
       Region 4qvf B 144-164 order
       Region 4qvf B 165-166 disorder
 Evidence X-RAY 3io8 D Reference
       Region 3io8 D 141-142 disorder
       Region 3io8 D 143-161 order
       Region 3io8 D 162-166 disorder
 Evidence X-RAY 3io8 B Reference
       Region 3io8 B 141-143 disorder
       Region 3io8 B 144-166 order
 Evidence X-RAY 3fdl B Reference
       Region 3fdl B 141-141 disorder
       Region 3fdl B 142-166 order
 Evidence X-RAY 4a1u B Reference
       Region 4a1u B 146-163 order
Seq 141-166 Hetero tetramer : Q16611
 Evidence X-RAY 5vww D Reference
       Region 5vww D 141-142 disorder
       Region 5vww D 143-161 order
       Region 5vww D 162-166 disorder
 Evidence X-RAY 5vww C Reference
       Region 5vww C 141-141 disorder
       Region 5vww C 142-166 order
Seq 141-166 Hetero tetramer : P97287,Q07820
 Evidence X-RAY 5vx2 D Reference
       Region 5vx2 D 141-165 order
       Region 5vx2 D 166-166 disorder
 Evidence X-RAY 5vx2 B Reference
       Region 5vx2 B 141-142 disorder
       Region 5vx2 B 143-165 order
       Region 5vx2 B 166-166 disorder
Seq 141-166 Hetero dimer : P0C736
 Evidence X-RAY 2v6q B Reference
       Region 2v6q B 141-163 order
       Region 2v6q B 164-166 disorder
Seq 141-166 Hetero dimer : P97287,Q07820
 Evidence X-RAY 2nl9 B Reference
       Region 2nl9 B 141-142 disorder
       Region 2nl9 B 143-165 order
       Region 2nl9 B 166-166 disorder
Seq 141-166 Hetero tetramer : Q08FX8
 Evidence X-RAY 4uf3 B Reference
       Region 4uf3 B 141-145 disorder
       Region 4uf3 B 146-163 order
       Region 4uf3 B 164-166 disorder
Seq 141-166 Hetero tetramer : Q07812
 Evidence X-RAY 4zie C Reference
       Region 4zie C 141-142 disorder
       Region 4zie C 143-164 order
       Region 4zie C 165-166 disorder
Seq 141-166 Hetero octamer : O57173
 Evidence X-RAY 4d2m D Reference
       Region 4d2m D 141-142 disorder
       Region 4d2m D 143-163 order
       Region 4d2m D 164-166 disorder
 Evidence X-RAY 4d2m B Reference
       Region 4d2m B 141-142 disorder
       Region 4d2m B 143-164 order
       Region 4d2m B 165-166 disorder
Seq 141-166 Hetero tetramer : Q16611
 Evidence X-RAY 5vwy B Reference
       Region 5vwy B 141-165 order
       Region 5vwy B 166-166 disorder
 Evidence X-RAY 5vwx D Reference
       Region 5vwx D 142-164 order
 Evidence X-RAY 5vwx B Reference
       Region 5vwx B 142-164 order
Seq 141-166 Hetero tetramer : Q16611
 Evidence X-RAY 5vwz D Reference
       Region 5vwz D 141-166 order
 Evidence X-RAY 5vwz B Reference
       Region 5vwz B 141-166 order
Seq 141-166 Hetero dimer : Q9HD36
 Evidence X-RAY 4b4s B Reference
       Region 4b4s B 141-142 disorder
       Region 4b4s B 143-166 order
Seq 141-166 Hetero dimer : P97287,Q07820
 Evidence X-RAY 3io9 B Reference
       Region 3io9 B 141-142 disorder
       Region 3io9 B 143-165 order
       Region 3io9 B 166-166 disorder
Seq 141-166 Hetero dimer : P0C6Z1
 Evidence X-RAY 2wh6 B Reference
       Region 2wh6 B 141-162 order
       Region 2wh6 B 163-166 disorder
Seq 141-166 Hetero tetramer : IID00720Complex
 Evidence X-RAY 2yq7 B Reference
       Region 2yq7 B 147-164 order
 Evidence X-RAY 2yq6 B Reference
       Region 2yq6 B 147-164 order
 Evidence X-RAY 5vx3 H Reference
       Region 5vx3 H 141-141 disorder
       Region 5vx3 H 142-164 order
       Region 5vx3 H 165-166 disorder
 Evidence X-RAY 5vx3 D Reference
       Region 5vx3 D 141-142 disorder
       Region 5vx3 D 143-164 order
       Region 5vx3 D 165-166 disorder
 Evidence X-RAY 5vx3 F Reference
       Region 5vx3 F 141-142 disorder
       Region 5vx3 F 143-164 order
       Region 5vx3 F 165-166 disorder
 Evidence X-RAY 5vx3 B Reference
       Region 5vx3 B 141-141 disorder
       Region 5vx3 B 142-162 order
       Region 5vx3 B 163-166 disorder
 Evidence X-RAY 4a1w R Reference
       Region 4a1w R 146-146 disorder
       Region 4a1w R 147-163 order
 Evidence X-RAY 4a1w Q Reference
       Region 4a1w Q 146-163 order
 Evidence X-RAY 4a1w S Reference
       Region 4a1w S 146-163 order
 Evidence X-RAY 4a1w P Reference
       Region 4a1w P 146-146 disorder
       Region 4a1w P 147-163 order
Seq 141-166 Hetero tetramer : Q16611
 Evidence X-RAY 5vx0 D Reference
       Region 5vx0 D 141-141 disorder
       Region 5vx0 D 142-165 order
       Region 5vx0 D 166-166 disorder
 Evidence X-RAY 5vx0 B Reference
       Region 5vx0 B 141-165 order
       Region 5vx0 B 166-166 disorder
Seq 141-166 Hetero dimer : Q6VZT9
 Evidence X-RAY 5wos B Reference
       Region 5wos B 141-143 disorder
       Region 5wos B 144-164 order
       Region 5wos B 165-166 disorder
Seq 143-165 Hetero dimer : Q07820
 Evidence X-RAY 3kj2 B Reference
       Region 3kj2 B 143-163 order
 Evidence X-RAY 3kj1 B Reference
       Region 3kj1 B 143-163 order
 Evidence X-RAY 3kj0 B Reference
       Region 3kj0 B 143-165 order
Seq 145-164 Hetero dimer : Q07812
 Evidence NMR 2k7w B Reference
       Region 2k7w B 145-164 order
Seq 146-165 Hetero dimer : IID50336Complex
 Evidence X-RAY 4yj4 B Reference
       Region 4yj4 B 146-163 order
       Region 4yj4 B 164-165 disorder
Seq 146-166 Hetero tetramer : IID00720Complex,IID50336Complex
 Evidence X-RAY 5c3g B Reference
       Region 5c3g B 146-147 disorder
       Region 5c3g B 148-163 order
       Region 5c3g B 164-166 disorder
Seq 146-166 Hetero dimer : IID00707Complex,IID00720Complex
 Evidence X-RAY 5agx C Reference
       Region 5agx C 146-166 order
Seq 146-166 Hetero dimer : IID00707Complex,IID00720Complex
 Evidence X-RAY 5agw D Reference
       Region 5agw D 146-166 order
Seq 146-166 Hetero dimer : IID00707Complex,IID00720Complex
 Evidence X-RAY 5agw C Reference
       Region 5agw C 146-164 order
       Region 5agw C 165-166 disorder
Seq 146-166 Hetero dimer : IID00707Complex,IID00720Complex
 Evidence X-RAY 5agx D Reference
       Region 5agx D 146-166 order
Seqphosphorylation
    69-69 Phosphoserine; by MAPK
    77-77 Phosphoserine
    87-87 Phosphoserine
    94-94 Phosphoserine
 
Prediction
NeProc
Disorder 1-139
Order 140-198
ProS 7-20,70-83,95-114,123-133
AlphaFold
Disorder 1-4,6-116,134-142,163-180
Order 5-5,117-133,143-162,181-198
Pfam Hmmer
PF06773 1-40 2.1e-29
SEG 84-94 ,180-194
Function
Function in SwissProt
Induces apoptosis and anoikis. Isoform BimL is more potent than isoform BimEL. Isoform Bim-alpha1, isoform Bim-alpha2 and isoform Bim-alpha3 induce apoptosis, although less potent than isoform BimEL, isoform BimL and isoform BimS. Isoform Bim-gamma induces apoptosis. Isoform Bim-alpha3 induces apoptosis possibly through a caspase-mediated pathway. Isoform BimAC and isoform BimABC lack the ability to induce apoptosis.