Search Keyword:


Search option:


IID50001
 UniprotP05221
ProteinNucleoplasmin
GeneNUPL_XENLA
OrganismXenopus laevis
Sequence LLPS PhaSepDB
PhaSePro
LLPSDB
DrLLPS
 Network xml rdf
Structure
Experiment
  :order   disorder   conflict   PDB cluster   ProS   Pfam Domain   SEG
200
 order/disorder by at least rule
     disorder by at least rule
     order by at least rule
 order/disorder by majority rule
Seq 1-124 Homo pentamer :
 Evidence X-RAY 2vtx K Reference
       Region 2vtx K 10-16 disorder
       Region 2vtx K 17-34 order
       Region 2vtx K 35-39 disorder
       Region 2vtx K 40-67 order
       Region 2vtx K 68-72 disorder
       Region 2vtx K 73-119 order
       Region 2vtx K 120-120 disorder
 Evidence X-RAY 2vtx J Reference
       Region 2vtx J 10-16 disorder
       Region 2vtx J 17-33 order
       Region 2vtx J 34-42 disorder
       Region 2vtx J 43-118 order
       Region 2vtx J 119-120 disorder
 Evidence X-RAY 2vtx I Reference
       Region 2vtx I 10-15 disorder
       Region 2vtx I 16-34 order
       Region 2vtx I 35-41 disorder
       Region 2vtx I 42-118 order
       Region 2vtx I 119-120 disorder
 Evidence X-RAY 2vtx H Reference
       Region 2vtx H 10-15 disorder
       Region 2vtx H 16-34 order
       Region 2vtx H 35-41 disorder
       Region 2vtx H 42-117 order
       Region 2vtx H 118-120 disorder
 Evidence X-RAY 2vtx G Reference
       Region 2vtx G 10-15 disorder
       Region 2vtx G 16-35 order
       Region 2vtx G 36-41 disorder
       Region 2vtx G 42-68 order
       Region 2vtx G 69-72 disorder
       Region 2vtx G 73-119 order
       Region 2vtx G 120-120 disorder
 Evidence X-RAY 2vtx E Reference
       Region 2vtx E 10-15 disorder
       Region 2vtx E 16-34 order
       Region 2vtx E 35-41 disorder
       Region 2vtx E 42-68 order
       Region 2vtx E 69-73 disorder
       Region 2vtx E 74-118 order
       Region 2vtx E 119-120 disorder
 Evidence X-RAY 2vtx D Reference
       Region 2vtx D 10-16 disorder
       Region 2vtx D 17-34 order
       Region 2vtx D 35-42 disorder
       Region 2vtx D 43-68 order
       Region 2vtx D 69-73 disorder
       Region 2vtx D 74-118 order
       Region 2vtx D 119-120 disorder
 Evidence X-RAY 2vtx C Reference
       Region 2vtx C 10-15 disorder
       Region 2vtx C 16-34 order
       Region 2vtx C 35-42 disorder
       Region 2vtx C 43-67 order
       Region 2vtx C 68-73 disorder
       Region 2vtx C 74-118 order
       Region 2vtx C 119-120 disorder
 Evidence X-RAY 2vtx B Reference
       Region 2vtx B 10-16 disorder
       Region 2vtx B 17-34 order
       Region 2vtx B 35-37 disorder
       Region 2vtx B 38-68 order
       Region 2vtx B 69-72 disorder
       Region 2vtx B 73-119 order
       Region 2vtx B 120-120 disorder
 Evidence X-RAY 2vtx A Reference
       Region 2vtx A 10-15 disorder
       Region 2vtx A 16-34 order
       Region 2vtx A 35-40 disorder
       Region 2vtx A 41-67 order
       Region 2vtx A 68-72 disorder
       Region 2vtx A 73-118 order
       Region 2vtx A 119-120 disorder
 Evidence X-RAY 1k5j E Reference
       Region 1k5j E 1-14 disorder
       Region 1k5j E 15-33 order
       Region 1k5j E 34-41 disorder
       Region 1k5j E 42-68 order
       Region 1k5j E 69-72 disorder
       Region 1k5j E 73-119 order
       Region 1k5j E 120-124 disorder
 Evidence X-RAY 1k5j D Reference
       Region 1k5j D 1-15 disorder
       Region 1k5j D 16-33 order
       Region 1k5j D 34-41 disorder
       Region 1k5j D 42-67 order
       Region 1k5j D 68-72 disorder
       Region 1k5j D 73-118 order
       Region 1k5j D 119-124 disorder
 Evidence X-RAY 1k5j C Reference
       Region 1k5j C 1-15 disorder
       Region 1k5j C 16-33 order
       Region 1k5j C 34-41 disorder
       Region 1k5j C 42-67 order
       Region 1k5j C 68-73 disorder
       Region 1k5j C 74-118 order
       Region 1k5j C 119-124 disorder
 Evidence X-RAY 1k5j B Reference
       Region 1k5j B 1-15 disorder
       Region 1k5j B 16-33 order
       Region 1k5j B 34-41 disorder
       Region 1k5j B 42-119 order
       Region 1k5j B 120-124 disorder
 Evidence X-RAY 1k5j A Reference
       Region 1k5j A 1-14 disorder
       Region 1k5j A 15-33 order
       Region 1k5j A 34-41 disorder
       Region 1k5j A 42-69 order
       Region 1k5j A 70-72 disorder
       Region 1k5j A 73-119 order
       Region 1k5j A 120-124 disorder
Seq 153-171 Hetero dimer : IID50012Complex
 Evidence X-RAY 1ee5 B Reference
       Region 1ee5 B 153-171 order
Seq 153-172 Hetero dimer : Q71VM4
 Evidence X-RAY 4bpl B Reference
       Region 4bpl B 153-172 order
Seq 153-172 Hetero dimer : IID50009Complex
 Evidence X-RAY 3ul1 A Reference
       Region 3ul1 A 153-172 order
 Evidence X-RAY 1ejy N Reference
       Region 1ejy N 155-170 order
SeqProS possible 153-172 Nuclear Localization Signal (NLS) Hetero dimer : IID50009Complex
       Region 1ejy N 155-170 order
       Region 3ul1 A 153-172 order
SeqProS possible 153-172 Nuclear Localization Signal (NLS) Hetero dimer : IID50012Complex
       Region 1ee5 B 153-171 order
Seqphosphorylation
    3-3 Phosphoserine
    4-4 Phosphothreonine
    6-6 Phosphoserine
    8-8 Phosphothreonine
    149-149 Phosphoserine
    182-182 Phosphoserine
    178-178 Phosphoserine
    177-177 Phosphoserine
Seqacetylation
    2-2 N-acetylalanine
 
Prediction
NeProc
Disorder 1-13,113-200
Order 14-112
ProS 113-120
AlphaFold
Disorder 1-12,39-39,122-200
Order 13-38,40-121
Pfam Hmmer
PF03066 13-200 9.2e-105
SEG 127-146 ,158-200
Function
Function in SwissProt
Acts as a chaperone for histones, such as histone H2A-H2B, and thus regulates the assembly of nucleosome cores (PubMed:11684019, PubMed:19055325). Involved in chromatin remodeling, especially during fertilization and early embryonic development (By similarity). May be involved in sperm chromatin decondensation during fertilization (PubMed:17510054).