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IID50003
 UniprotP09803
ProteinCadherin-1
GeneCdh1
OrganismMus musculus
Sequence LLPS PhaSepDB
PhaSePro
LLPSDB
DrLLPS
 Network xml rdf
Structure
Experiment
  :order   disorder   conflict   PDB cluster   ProS   Pfam Domain   SEG
884
 order/disorder by at least rule
     disorder by at least rule
     order by at least rule
 order/disorder by majority rule
Seq 156-300 Monomer :
 Evidence NMR 1suh A Reference
       Region 1suh A 156-156 disorder
       Region 1suh A 157-260 order
       Region 1suh A 258-260 high_rmsd
       Region 1suh A 261-300 disorder
Seq 156-380 Homo dimer :
 Evidence X-RAY 2qvf B Reference
       Region 2qvf B 157-369 order
 Evidence X-RAY 3qrb B Reference
       Region 3qrb B 157-369 order
 Evidence X-RAY 3qrb A Reference
       Region 3qrb A 157-369 order
 Evidence X-RAY 3q2n B Reference
       Region 3q2n B 157-369 order
 Evidence X-RAY 3q2n A Reference
       Region 3q2n A 157-369 order
 Evidence X-RAY 3q2l B Reference
       Region 3q2l B 157-369 order
 Evidence X-RAY 3q2l A Reference
       Region 3q2l A 157-369 order
 Evidence X-RAY 3lni B Reference
       Region 3lni B 157-157 disorder
       Region 3lni B 158-182 order
       Region 3lni B 183-187 disorder
       Region 3lni B 188-369 order
 Evidence X-RAY 3lni A Reference
       Region 3lni A 157-184 order
       Region 3lni A 185-186 disorder
       Region 3lni A 187-369 order
 Evidence X-RAY 3lnh B Reference
       Region 3lnh B 157-160 disorder
       Region 3lnh B 161-369 order
 Evidence X-RAY 3lnh A Reference
       Region 3lnh A 157-160 disorder
       Region 3lnh A 161-369 order
 Evidence X-RAY 3lng B Reference
       Region 3lng B 157-157 disorder
       Region 3lng B 158-369 order
 Evidence X-RAY 3lng A Reference
       Region 3lng A 157-157 disorder
       Region 3lng A 158-369 order
 Evidence X-RAY 3lne A Reference
       Region 3lne A 157-369 order
 Evidence X-RAY 1ff5 B Reference
       Region 1ff5 B 157-374 order
 Evidence X-RAY 1ff5 A Reference
       Region 1ff5 A 157-374 order
 Evidence X-RAY 1edh B Reference
       Region 1edh B 156-158 disorder
       Region 1edh B 159-369 order
       Region 1edh B 370-380 disorder
 Evidence X-RAY 1edh A Reference
       Region 1edh A 156-158 disorder
       Region 1edh A 159-369 order
       Region 1edh A 370-380 disorder
Seq 157-369 Monomer :
 Evidence X-RAY 1q1p A Reference
       Region 1q1p A 158-369 order
 Evidence X-RAY 3lnf B Reference
       Region 3lnf B 157-160 disorder
       Region 3lnf B 161-183 order
       Region 3lnf B 184-187 disorder
       Region 3lnf B 188-369 order
 Evidence X-RAY 3lnf A Reference
       Region 3lnf A 157-158 disorder
       Region 3lnf A 159-369 order
Seq 157-369 Hetero pentamer : A5HZZ4,A5HZZ5,A5HZZ6
 Evidence X-RAY 4qd2 J Reference
       Region 4qd2 J 157-157 disorder
       Region 4qd2 J 158-369 order
 Evidence X-RAY 4qd2 E Reference
       Region 4qd2 E 157-157 disorder
       Region 4qd2 E 158-369 order
Seq 157-700 Homo dimer :
 Evidence X-RAY 3q2v B Reference
       Region 3q2v B 157-590 order
       Region 3q2v B 591-617 disorder
       Region 3q2v B 618-623 order
       Region 3q2v B 624-700 disorder
 Evidence X-RAY 3q2v A Reference
       Region 3q2v A 157-659 order
       Region 3q2v A 660-663 disorder
       Region 3q2v A 664-692 order
       Region 3q2v A 693-700 disorder
Seq 158-256 Hetero dimer : P0DJM0
 Evidence X-RAY 2omw B Reference
       Region 2omw B 158-256 order
Seq 734-884 Hetero trimer : IID50011Complex
 Evidence X-RAY 1i7x D Reference
       Region 1i7x D 734-785 disorder
       Region 1i7x D 786-791 order
       Region 1i7x D 792-809 disorder
       Region 1i7x D 810-840 order
       Region 1i7x D 841-853 disorder
       Region 1i7x D 854-879 order
       Region 1i7x D 880-884 disorder
 Evidence X-RAY 1i7x B Reference
       Region 1i7x B 734-783 disorder
       Region 1i7x B 784-840 order
       Region 1i7x B 841-884 disorder
Seq 734-884 Hetero tetramer : IID50011Complex
 Evidence X-RAY 1i7w D Reference
       Region 1i7w D 734-787 disorder
       Region 1i7w D 788-791 order
       Region 1i7w D 792-812 disorder
       Region 1i7w D 813-850 order
       Region 1i7w D 851-860 disorder
       Region 1i7w D 861-878 order
       Region 1i7w D 879-884 disorder
 Evidence X-RAY 1i7w B Reference
       Region 1i7w B 734-816 disorder
       Region 1i7w B 817-850 order
       Region 1i7w B 851-861 disorder
       Region 1i7w B 862-878 order
       Region 1i7w B 879-884 disorder
Seqdisorder 773-884
 Evidence NMR Reference
       Region 773-884 disorder
Seq 778-884 Hetero tetramer : IID00298Complex
 Evidence X-RAY 3ifq D Reference
       Region 3ifq D 778-783 disorder
       Region 3ifq D 784-851 order
       Region 3ifq D 852-854 disorder
       Region 3ifq D 855-877 order
       Region 3ifq D 878-884 disorder
 Evidence X-RAY 3ifq C Reference
       Region 3ifq C 778-783 disorder
       Region 3ifq C 784-852 order
       Region 3ifq C 853-857 disorder
       Region 3ifq C 858-881 order
       Region 3ifq C 882-884 disorder
SeqProS verified 784-881 Hetero tetramer : IID50011Complex
       Region 1i7w B 817-850 order
       Region 1i7w B 862-878 order
       Region 1i7w D 788-791 order
       Region 1i7w D 813-850 order
       Region 1i7w D 861-878 order
       Region 773-884 disorder
SeqProS verified 784-881 Hetero tetramer : IID00298Complex
       Region 3ifq C 784-852 order
       Region 3ifq C 858-881 order
       Region 3ifq D 784-851 order
       Region 3ifq D 855-877 order
       Region 773-884 disorder
SeqProS verified 784-881 Hetero trimer : IID50011Complex
       Region 1i7x B 784-840 order
       Region 1i7x D 786-791 order
       Region 1i7x D 810-840 order
       Region 1i7x D 854-879 order
       Region 773-884 disorder
Seqphosphorylation
    848-848 Phosphoserine
    795-795 Phosphoserine
    840-840 Phosphoserine
    842-842 Phosphoserine
    757-757 Phosphotyrosine; by SRC
    772-772 Phosphoserine
    756-756 Phosphotyrosine; by SRC
    755-755 Phosphotyrosine; by SRC
 
Prediction
NeProc
Disorder 1-24,121-147,734-802,841-858,881-884
Order 25-120,148-733,803-840,859-880
ProS 4-24,141-147,734-739,747-795,841-851
AlphaFold
Disorder 1-30,63-67,121-159,694-712,733-798,824-862,878-884
Order 31-62,68-120,160-693,713-732,799-823,863-877
Pfam Hmmer
PF00028 161-255 1.6e-18
PF00028 269-368 5.6e-30
PF00028 382-480 6.2e-22
PF00028 493-588 1.4e-14
PF00028 600-688 1.8e-10
PF01049 734-881 1.2e-96
SEG 11-15 ,123-131 ,474-482 ,579-593 ,711-731 ,755-768 ,839-863
Function
Function in SwissProt
Cadherins are calcium-dependent cell adhesion proteins (PubMed:11976333). They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. CDH1 is involved in mechanisms regulating cell-cell adhesions, mobility and proliferation of epithelial cells (PubMed:11976333). Has a potent invasive suppressor role. It is a ligand for integrin alpha-E/beta-7 (By similarity).
E-Cad/CTF2 promotes non-amyloidogenic degradation of Abeta precursors. Has a strong inhibitory effect on APP C99 and C83 production (By similarity).
(Microbial infection) Does not function as a receptor for L.monocytogenes internalin A (InlA); mutating a single surface-exposed residue confers receptor activity to this protein and promotes uptake of the bacteria.
Biological Process
Diagram with PDB data
Cdh1/Ctnnb1BETA-CATENIN/E-CADHERIN COMPLEX