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IID50005
 UniprotP27577
ProteinProtein C-ets-1
GeneEts1
OrganismMus musculus
Sequence LLPS PhaSepDB
PhaSePro
LLPSDB
DrLLPS
 Network xml rdf
Structure
Experiment
  :order   disorder   conflict   PDB cluster   ProS   Pfam Domain   SEG
440
 order/disorder by at least rule
     disorder by at least rule
     order by at least rule
 order/disorder by majority rule
Seq 29-138 Monomer :
 Evidence NMR 2jv3 A Reference
       Region 2jv3 A 29-138 order
       Region 2jv3 A 29-37 high_rmsd
 Evidence NMR 2kmd A Reference
       Region 2kmd A 29-138 order
       Region 2kmd A 29-51 high_rmsd
       Region 2kmd A 137-138 high_rmsd
Seq 280-440 Hetero dimer : IID00067Complex
 Evidence X-RAY 1mdm B Reference
       Region 1mdm B 280-308 disorder
       Region 1mdm B 309-437 order
       Region 1mdm B 438-440 disorder
 Evidence X-RAY 1k78 F Reference
       Region 1k78 F 331-333 disorder
       Region 1k78 F 334-436 order
       Region 1k78 F 437-440 disorder
Seq 300-440 Homo dimer :
 Evidence X-RAY 1md0 B Reference
       Region 1md0 B 300-437 order
       Region 1md0 B 438-440 disorder
 Evidence X-RAY 1md0 A Reference
       Region 1md0 A 300-437 order
       Region 1md0 A 438-440 disorder
Seq 301-440 Monomer :
 Evidence NMR 1r36 A Reference
       Region 1r36 A 301-440 order
       Region 1r36 A 440-440 high_rmsd
 Evidence X-RAY 1k7a D Reference
       Region 1k7a D 331-332 disorder
       Region 1k7a D 333-436 order
       Region 1k7a D 437-440 disorder
 Evidence X-RAY 1k7a A Reference
       Region 1k7a A 331-332 disorder
       Region 1k7a A 333-436 order
       Region 1k7a A 437-440 disorder
 Evidence X-RAY 1k79 D Reference
       Region 1k79 D 331-332 disorder
       Region 1k79 D 333-436 order
       Region 1k79 D 437-440 disorder
 Evidence X-RAY 1k79 A Reference
       Region 1k79 A 331-332 disorder
       Region 1k79 A 333-436 order
       Region 1k79 A 437-440 disorder
Seq 331-440 Hetero dimer : IID00067Complex
 Evidence X-RAY 1k78 B Reference
       Region 1k78 B 331-334 disorder
       Region 1k78 B 335-436 order
       Region 1k78 B 437-440 disorder
SeqProS verified 300-308 This region is disordered in the complex with DNA, and ordered in the absence of DNA by binding upon Ets1 itself. Homo dimer :
       Region 1md0 A 300-437 order
       Region 1md0 B 300-437 order
       Region 1mdm B 280-308 disorder
Seqphosphorylation
    270-270 Phosphoserine
    282-282 Phosphoserine; by CaMK2
    223-223 Phosphotyrosine
    251-251 Phosphoserine; by CaMK2
    254-254 Phosphoserine
    265-265 Phosphothreonine
    38-38 Phosphothreonine; by MAPK
    267-267 Phosphoserine
    285-285 Phosphoserine; by CaMK2
Seqacetylation
    15-15 N6-acetyllysine; alternate
    8-8 N6-acetyllysine; alternate
    305-305 N6-acetyllysine
 
Prediction
NeProc
Disorder 1-42,143-327,437-440
Order 43-142,328-436
ProS 1-24,29-42,143-223,231-295,304-308,318-327,437-440
AlphaFold
Disorder 1-46,48-48,136-301,310-317,439-440
Order 47-47,49-135,302-309,318-438
Pfam Hmmer
PF02198 53-136 1e-49
PF00178 334-417 3.3e-64
SEG 266-278
Function
Function in SwissProt
Transcription factor. Directly controls the expression of cytokine and chemokine genes in a wide variety of different cellular contexts. May control the differentiation, survival and proliferation of lymphoid cells. May also regulate angiogenesis through regulation of expression of genes controlling endothelial cell migration and invasion (By similarity).