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IID50006
 UniprotP27782
ProteinLymphoid enhancer-binding factor 1
GeneLef1
OrganismMus musculus
Sequence LLPS PhaSepDB
PhaSePro
LLPSDB
DrLLPS
 Network xml rdf
Structure
Experiment
  :order   disorder   conflict   PDB cluster   ProS   Pfam Domain   SEG
397
 order/disorder by at least rule
     disorder by at least rule
     order by at least rule
 order/disorder by majority rule
Seq 1-63 Hetero dimer : IID50011Complex
 Evidence X-RAY 3oux B Reference
       Region 3oux B 1-10 disorder
       Region 3oux B 11-41 order
       Region 3oux B 42-44 disorder
       Region 3oux B 45-60 order
       Region 3oux B 61-63 disorder
Seq 1-63 Hetero dimer : IID50011Complex
 Evidence X-RAY 3ouw B Reference
       Region 3ouw B 1-10 disorder
       Region 3ouw B 11-25 order
       Region 3ouw B 26-47 disorder
       Region 3ouw B 48-60 order
       Region 3ouw B 61-63 disorder
Seq 296-380 Monomer :
 Evidence NMR 2lef A Reference
       Region 2lef A 296-380 order
       Region 2lef A 378-380 high_rmsd
Seqdisorder 361-370
 Evidence NMR¸ CD Reference
       Region 361-370 disorder
SeqProS possible 11-25,48-60 beta-catein binding domain (CBD) Hetero dimer : IID50011Complex
       Region 3ouw B 11-25 order
       Region 3ouw B 48-60 order
SeqProS possible 11-41,45-60 beta-catein binding domain (CBD) Hetero dimer : IID50011Complex
       Region 3oux B 11-41 order
       Region 3oux B 45-60 order
SeqProS verified 361-370 :
       Region 2lef A 296-380 order
       Region 361-370 disorder
Seqphosphorylation
    130-130 Phosphoserine
    153-153 Phosphothreonine; by NLK
    164-164 Phosphoserine; by NLK
 
Prediction
NeProc
Disorder 1-119,126-296,371-397
Order 297-370
ProS 1-30,45-58,86-119,130-140,152-182,193-199,206-218,259-263,274-283,390-397
AlphaFold
Disorder 1-48,55-294,371-397
Order 49-54,295-370
Pfam Hmmer
PF08347 1-211 4.3e-128
PF00505 297-365 8.7e-30
SEG 6-11 ,245-259 ,372-380
Function
Function in SwissProt
Transcription factor that binds DNA in a sequence-specific manner (By similarity). Participates in the Wnt signaling pathway (PubMed:11445543). Activates transcription of target genes in the presence of CTNNB1 and EP300 (PubMed:12446687). PIASG antagonizes both Wnt-dependent and Wnt-independent activation by LEF1 (PubMed:11731474). TLE1, TLE2, TLE3 and TLE4 repress transactivation mediated by LEF1 and CTNNB1 (By similarity). Regulates T-cell receptor alpha enhancer function (By similarity). Required for IL17A expressing gamma-delta T-cell maturation and development, via binding to regulator loci of BLK to modulate expression (PubMed:23562159). May play a role in hair cell differentiation and follicle morphogenesis (PubMed:11445543).