IDEAL List

IDEAL

IID50009
UniprotP52293
ProteinImportin subunit alpha-1
GeneKpna2
OrganismMus musculus
Sequence LLPS PhaSepDB
PhaSePro
LLPSDB
DrLLPS Network xml rdf

Structure

Experiment

:order disorder conflict PDB cluster ProS Pfam Domain SEG

529

order/disorder by at least rule

disorder by at least rule

order by at least rule

order/disorder by majority rule

Seqdisorder 1-70

Evidence CD Reference

Region 1-70 disorder

Seq 1-529 Monomer :

Evidence X-RAY 4u5o A Reference

Region 4u5o A 72-497 order

Evidence X-RAY 4u5n A Reference

Region 4u5n A 72-497 order

Evidence X-RAY 4u5l A Reference

Region 4u5l A 72-497 order

Evidence X-RAY 4u5v A Reference

Region 4u5v A 72-497 order

Evidence X-RAY 4u5u A Reference

Region 4u5u A 72-497 order

Evidence X-RAY 4u5s A Reference

Region 4u5s A 72-497 order

Evidence X-RAY 4u58 A Reference

Region 4u58 A 72-497 order

Evidence X-RAY 4u54 A Reference

Region 4u54 A 74-498 order

Evidence X-RAY 3tpo A Reference

Region 3tpo A 1-43 disorder

Region 3tpo A 44-54 order

Region 3tpo A 55-69 disorder

Region 3tpo A 70-496 order

Region 3tpo A 497-529 disorder

Evidence X-RAY 1ial A Reference

Region 1ial A 44-54 order

Region 1ial A 55-69 disorder

Region 1ial A 70-496 order

Seq 2-529 Hetero trimer :

Evidence X-RAY 5v5o C Reference

Region 5v5o C 2-74 disorder

Region 5v5o C 75-497 order

Region 5v5o C 498-529 disorder

Seq 2-529 Hetero trimer : P04295

Evidence X-RAY 5huw C Reference

Region 5huw C 2-74 disorder

Region 5huw C 75-497 order

Region 5huw C 498-529 disorder

Seq 2-529 Hetero trimer : D3YRZ5

Evidence X-RAY 5huy C Reference

Region 5huy C 2-74 disorder

Region 5huy C 75-497 order

Region 5huy C 498-529 disorder

Seq 2-529 Hetero trimer :

Evidence X-RAY 5v5p C Reference

Region 5v5p C 2-74 disorder

Region 5v5p C 75-497 order

Region 5v5p C 498-529 disorder

Seq 44-54,70-529 Hetero trimer :

Evidence X-RAY 1iq1 C Reference

Region 1iq1 C 70-71 disorder

Region 1iq1 C 72-497 order

Region 1iq1 C 498-529 disorder

Evidence X-RAY 1iq1 B Reference

Region 1iq1 B 44-44 disorder

Region 1iq1 B 45-53 order

Region 1iq1 B 54-54 disorder

Evidence X-RAY 1iq1 A Reference

Region 1iq1 A 44-46 disorder

Region 1iq1 A 47-53 order

Region 1iq1 A 54-54 disorder

Seq 69-529 Hetero dimer : P31345

Evidence X-RAY 4uaf B Reference

Region 4uaf B 69-71 disorder

Region 4uaf B 72-496 order

Region 4uaf B 497-529 disorder

Seq 70-496 Hetero dimer : IID00020Complex

Evidence X-RAY 3btr C Reference

Region 3btr C 70-496 order

Seq 70-497 Hetero dimer : IID00006Complex

Evidence X-RAY 1y2a C Reference

Region 1y2a C 70-74 disorder

Region 1y2a C 75-497 order

Seq 70-497 Hetero dimer : Q14980

Evidence X-RAY 5gxw A Reference

Region 5gxw A 70-497 order

Seq 70-528 Hetero trimer : P33316

Evidence X-RAY 4mz6 E Reference

Region 4mz6 E 70-71 disorder

Region 4mz6 E 72-497 order

Region 4mz6 E 498-528 disorder

Evidence X-RAY 4mz5 E Reference

Region 4mz5 E 70-70 disorder

Region 4mz5 E 71-497 order

Region 4mz5 E 498-528 disorder

Seq 70-528 Hetero trimer :

Evidence X-RAY 5umz B Reference

Region 5umz B 70-71 disorder

Region 5umz B 72-497 order

Region 5umz B 498-528 disorder

Seq 70-528 Hetero dimer : Q68SX0

Evidence X-RAY 4htv A Reference

Region 4htv A 70-70 disorder

Region 4htv A 71-497 order

Region 4htv A 498-528 disorder

Seq 70-529 Hetero dimer :

Evidence X-RAY 3ukw B Reference

Region 3ukw B 70-71 disorder

Region 3ukw B 72-497 order

Region 3ukw B 498-529 disorder

Seq 70-529 Hetero trimer : P28715

Evidence X-RAY 5ekf A Reference

Region 5ekf A 70-71 disorder

Region 5ekf A 72-496 order

Region 5ekf A 497-529 disorder

Seq 70-529 Hetero dimer : P54278

Evidence X-RAY 5u5r A Reference

Region 5u5r A 70-71 disorder

Region 5u5r A 72-497 order

Region 5u5r A 498-529 disorder

Seq 70-529 Hetero trimer : IID90002Complex

Evidence X-RAY 1q1t C Reference

Region 1q1t C 70-496 order

Region 1q1t C 497-529 disorder

Evidence X-RAY 1q1s C Reference

Region 1q1s C 70-497 order

Region 1q1s C 498-529 disorder

Evidence X-RAY 1ejl I Reference

Region 1ejl I 70-71 disorder

Region 1ejl I 72-497 order

Region 1ejl I 498-529 disorder

Seq 70-529 Hetero trimer : P40692

Evidence X-RAY 5u5p A Reference

Region 5u5p A 70-71 disorder

Region 5u5p A 72-497 order

Region 5u5p A 498-529 disorder

Seq 70-529 Hetero dimer : Q8AZK7

Evidence X-RAY 5x8n A Reference

Region 5x8n A 70-72 disorder

Region 5x8n A 73-497 order

Region 5x8n A 498-529 disorder

Seq 70-529 Hetero hexamer : Q73369

Evidence X-RAY 5b56 B Reference

Region 5b56 B 70-70 disorder

Region 5b56 B 71-502 order

Region 5b56 B 503-529 disorder

Evidence X-RAY 5b56 A Reference

Region 5b56 A 70-498 order

Region 5b56 A 499-529 disorder

Seq 70-529 Hetero dimer : Q9UGN5

Evidence X-RAY 5d5k C Reference

Region 5d5k C 70-72 disorder

Region 5d5k C 73-496 order

Region 5d5k C 497-529 disorder

Seq 70-529 Hetero dimer : IID50172Complex

Evidence X-RAY 3uky B Reference

Region 3uky B 70-70 disorder

Region 3uky B 71-497 order

Region 3uky B 498-529 disorder

Seq 70-529 Hetero dimer : P18887

Evidence X-RAY 5e6q B Reference

Region 5e6q B 70-71 disorder

Region 5e6q B 72-496 order

Region 5e6q B 497-529 disorder

Seq 70-529 Hetero dimer :

Evidence X-RAY 5klt B Reference

Region 5klt B 70-71 disorder

Region 5klt B 72-497 order

Region 5klt B 498-529 disorder

Seq 70-529 Hetero dimer : P04326

Evidence X-RAY 5svz A Reference

Region 5svz A 70-71 disorder

Region 5svz A 72-497 order

Region 5svz A 498-529 disorder

Seq 70-529 Hetero dimer : IID00017Complex

Evidence X-RAY 1pjm B Reference

Region 1pjm B 70-70 disorder

Region 1pjm B 71-497 order

Region 1pjm B 498-529 disorder

Seq 70-529 Hetero dimer : Q6NUF4

Evidence X-RAY 3knd A Reference

Region 3knd A 70-497 order

Region 3knd A 498-529 disorder

Seq 70-529 Hetero dimer : IID00024Complex

Evidence X-RAY 3rz9 A Reference

Region 3rz9 A 70-71 disorder

Region 3rz9 A 72-496 order

Region 3rz9 A 497-529 disorder

Seq 70-529 Hetero dimer : IID00023Complex

Evidence X-RAY 3rzx A Reference

Region 3rzx A 70-70 disorder

Region 3rzx A 71-497 order

Region 3rzx A 498-529 disorder

Seq 70-529 Hetero dimer : P28715

Evidence X-RAY 5ekg A Reference

Region 5ekg A 70-71 disorder

Region 5ekg A 72-496 order

Region 5ekg A 497-529 disorder

Seq 70-529 Hetero dimer :

Evidence X-RAY 3ukx B Reference

Region 3ukx B 70-71 disorder

Region 3ukx B 72-497 order

Region 3ukx B 498-529 disorder

Seq 70-529 Hetero dimer : IID50001Complex

Evidence X-RAY 3ul1 B Reference

Region 3ul1 B 70-71 disorder

Region 3ul1 B 72-497 order

Region 3ul1 B 498-529 disorder

Evidence X-RAY 1ejy I Reference

Region 1ejy I 70-71 disorder

Region 1ejy I 72-497 order

Region 1ejy I 498-529 disorder

Seq 70-529 Hetero trimer : IID90004Complex

Evidence X-RAY 5wun A Reference

Region 5wun A 70-71 disorder

Region 5wun A 72-497 order

Region 5wun A 498-529 disorder

Evidence X-RAY 5wum A Reference

Region 5wum A 70-71 disorder

Region 5wum A 72-497 order

Region 5wum A 498-529 disorder

Seq 70-529 Hetero dimer :

Evidence X-RAY 5klr B Reference

Region 5klr B 70-71 disorder

Region 5klr B 72-497 order

Region 5klr B 498-529 disorder

Seq 70-529 Hetero dimer :

Evidence X-RAY 4ba3 A Reference

Region 4ba3 A 70-496 order

Region 4ba3 A 497-529 disorder

Seq 70-529 Hetero dimer : IID50002Complex

Evidence X-RAY 1pjn B Reference

Region 1pjn B 70-71 disorder

Region 1pjn B 72-497 order

Region 1pjn B 498-529 disorder

Seq 70-529 Hetero dimer : P52591

Evidence X-RAY 4yi0 C Reference

Region 4yi0 C 70-72 disorder

Region 4yi0 C 73-497 order

Region 4yi0 C 498-529 disorder

Seq 70-529 Hetero dimer : Q9Y696

Evidence X-RAY 3oqs A Reference

Region 3oqs A 70-71 disorder

Region 3oqs A 72-496 order

Region 3oqs A 497-529 disorder

Seq 70-529 Hetero dimer : IID50179Complex

Evidence X-RAY 3ul0 B Reference

Region 3ul0 B 70-70 disorder

Region 3ul0 B 71-496 order

Region 3ul0 B 497-529 disorder

Evidence X-RAY 3ukz B Reference

Region 3ukz B 70-70 disorder

Region 3ukz B 71-497 order

Region 3ukz B 498-529 disorder

Seq 70-529 Hetero dimer : IID00044Complex

Evidence X-RAY 3uvu A Reference

Region 3uvu A 70-71 disorder

Region 3uvu A 72-496 order

Region 3uvu A 497-529 disorder

Seq 70-529 Hetero dimer : P21827

Evidence X-RAY 4oih A Reference

Region 4oih A 70-71 disorder

Region 4oih A 72-497 order

Region 4oih A 498-529 disorder

Seq 70-529 Hetero dimer : Q9NRQ2

Evidence X-RAY 3q5u A Reference

Region 3q5u A 70-74 disorder

Region 3q5u A 75-497 order

Region 3q5u A 498-529 disorder

Seq 71-496 Hetero dimer : P09592

Evidence X-RAY 3ve6 A Reference

Region 3ve6 A 71-496 order

Seq 71-497 Hetero trimer :

Evidence X-RAY 3l3q A Reference

Region 3l3q A 71-497 order

Seq 71-497 Hetero dimer : P12823

Evidence X-RAY 5hhg E Reference

Region 5hhg E 71-497 order

Seq 71-529 Hetero dimer : B6VDJ7

Evidence X-RAY 5fc8 E Reference

Region 5fc8 E 71-497 order

Region 5fc8 E 498-529 disorder

Seq 72-496 Hetero trimer :

Evidence X-RAY 2ynr A Reference

Region 2ynr A 72-496 order

Seq 72-496 Hetero trimer : IID50235Complex

Evidence X-RAY 3zin A Reference

Region 3zin A 72-496 order

Seq 72-496 Hetero trimer :

Evidence X-RAY 3zio A Reference

Region 3zio A 72-496 order

Seq 72-497 Hetero trimer :

Evidence X-RAY 3zip A Reference

Region 3zip A 72-497 order

Seq 72-497 Hetero trimer :

Evidence X-RAY 3zir A Reference

Region 3zir A 72-497 order

Seq 72-497 Hetero trimer :

Evidence X-RAY 3ziq A Reference

Region 3ziq A 72-497 order

Seq 72-497 Hetero dimer : Q15020

Evidence X-RAY 5ctt A Reference

Region 5ctt A 72-497 order

Seq 72-498 Hetero dimer : P03466

Evidence X-RAY 4zdu A Reference

Region 4zdu A 72-75 disorder

Region 4zdu A 76-105 order

Region 4zdu A 106-110 disorder

Region 4zdu A 111-496 order

Region 4zdu A 497-498 disorder

Seq 72-529 Hetero trimer : P35680

Evidence X-RAY 5k9s A Reference

Region 5k9s A 72-73 disorder

Region 5k9s A 74-498 order

Region 5k9s A 499-529 disorder

Seq 75-496 Hetero dimer :

Evidence X-RAY 3tpm A Reference

Region 3tpm A 75-496 order

Seq 75-498 Hetero dimer : IID50016Complex

Evidence X-RAY 2c1m A Reference

Region 2c1m A 75-498 order

SeqProS verified 44-54

This region takes an ordered structure when it binds upon another region of this protein. Hetero trimer :

Region 1iq1 A 47-53 order

Region 1iq1 B 45-53 order

Region 1-70 disorder

SeqProS verified 44-54

This region takes an ordered structure when it binds upon another region of this protein. :

Region 1ial A 44-54 order

Region 3tpo A 44-54 order

Region 1-70 disorder

Seqphosphorylation

62-62 Phosphoserine

Seqacetylation

2-2 N-acetylserine

Prediction

NeProc

Disorder 1-74,504-529

Order 75-499

ProS 1-55,67-71,504-519,525-529

AlphaFold

Disorder 1-48,52-74,498-529

Order 49-51,75-497

Pfam Hmmer

PF01749 5-99 6.2e-42

PF00514 108-149 6e-09

PF00514 151-191 1.4e-12

PF00514 193-238 0.00021

PF00514 241-280 8.3e-09

PF00514 282-322 7.7e-08

PF00514 324-364 2.6e-12

PF00514 366-406 1.8e-10

PF00514 409-449 2.6e-08

SEG 207-218

Function

Function in SwissProt

Functions in nuclear protein import as an adapter protein for nuclear receptor KPNB1. Binds specifically and directly to substrates containing either a simple or bipartite NLS motif. Docking of the importin/substrate complex to the nuclear pore complex (NPC) is mediated by KPNB1 through binding to nucleoporin FxFG repeats and the complex is subsequently translocated through the pore by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to importin-beta and the three components separate and importin-alpha and -beta are re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran from importin. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus.

Biological Process

See also
Diagram with PDB data
LT_SV40/Kpna2	MOUSE IMPORTIN ALPHA-SV40 LARGE T ANTIGEN NLS PEPTIDE COMPLEX
HIF1A/EP300	NMR Structures of the HIF-1alpha CTAD/p300 CH1 Complex