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IID50010
 UniprotP70062
ProteinTranscription factor 7-like 1-A
Genetcf7l1-a
OrganismXenopus laevis
Sequence LLPS PhaSepDB
PhaSePro
LLPSDB
DrLLPS
 Network xml rdf
Structure
Experiment
  :order   disorder   conflict   PDB cluster   ProS   Pfam Domain   SEG
554
 order/disorder by at least rule
     disorder by at least rule
     order by at least rule
 order/disorder by majority rule
Seq 1-61 Hetero dimer : IID00039Complex
 Evidence X-RAY 1g3j D Reference
       Region 1g3j D 1-1 disorder
       Region 1g3j D 2-24 order
       Region 1g3j D 25-39 disorder
       Region 1g3j D 40-50 order
       Region 1g3j D 51-61 disorder
 Evidence X-RAY 1g3j B Reference
       Region 1g3j B 1-1 disorder
       Region 1g3j B 2-29 order
       Region 1g3j B 30-39 disorder
       Region 1g3j B 40-52 order
       Region 1g3j B 53-61 disorder
SeqProS possible 2-29,40-52 Beta catenin binding domain(CBD) Hetero dimer : IID00039Complex
       Region 1g3j B 2-29 order
       Region 1g3j D 2-24 order
       Region 1g3j B 40-52 order
       Region 1g3j D 40-50 order
 
Prediction
NeProc
Disorder 1-133,140-325,401-554
Order 134-139,326-400
ProS 1-29,37-53,71-96,106-117,122-133,140-143,154-157,165-177,185-192,225-237,246-251,285-296,303-311,410-431,442-447,539-554
AlphaFold
Disorder 1-42,44-79,82-83,85-321,399-554
Order 43-43,80-81,84-84,322-398
Pfam Hmmer
PF08347 1-228 1.1e-148
PF00505 324-392 5.5e-28
SEG 49-64 ,157-168 ,202-216 ,315-327 ,445-464 ,482-528 ,532-548
Function
Function in SwissProt
Participates in the Wnt signaling pathway. Binds to DNA and acts as a repressor in the absence of ctnnb1-A and possibly ctnnb1-B, and as an activator in the presence of these proteins. Required early in development for the establishment of the dorsal body axis in response to maternal Wnt signaling. Also required during development of the CNS for the establishment of dorsal-ventral patterning in the prospective diencephalon.