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IID50012
 UniprotQ02821
ProteinImportin subunit alpha
GeneSRP1
OrganismSaccharomyces cerevisiae (strain ATCC 204508 / S288c)
Sequence LLPS PhaSepDB
PhaSePro
LLPSDB
DrLLPS
 Network xml rdf
Structure
Experiment
  :order   disorder   conflict   PDB cluster   ProS   Pfam Domain   SEG
542
 order/disorder by at least rule
     disorder by at least rule
     order by at least rule
 order/disorder by majority rule
Seq 1-530 Hetero trimer : IID50075Complex,IID50081Complex
 Evidence X-RAY 1wa5 B Reference
       Region 1wa5 B 1-11 disorder
       Region 1wa5 B 12-19 order
       Region 1wa5 B 20-30 disorder
       Region 1wa5 B 31-58 order
       Region 1wa5 B 59-86 disorder
       Region 1wa5 B 87-513 order
       Region 1wa5 B 514-530 disorder
Seq 1-542 Hetero dimer : P21827
 Evidence X-RAY 5t94 B Reference
       Region 5t94 B 1-87 disorder
       Region 5t94 B 88-509 order
       Region 5t94 B 510-542 disorder
Seq 87-509 Hetero trimer : IID00012Complex
 Evidence X-RAY 1ee4 B Reference
       Region 1ee4 B 87-509 order
 Evidence X-RAY 1ee4 A Reference
       Region 1ee4 A 87-509 order
Seq 87-510 Hetero dimer : IID50001Complex
 Evidence X-RAY 1ee5 A Reference
       Region 1ee5 A 87-89 disorder
       Region 1ee5 A 90-510 order
Seq 88-509 Hetero dimer : IID50288Complex
 Evidence X-RAY 4pvz A Reference
       Region 4pvz A 88-509 order
Seq 88-509 Hetero dimer : IID50288Complex
 Evidence X-RAY 4pvz B Reference
       Region 4pvz B 88-509 order
Seq 88-509 Hetero dimer : IID50325Complex
 Evidence X-RAY 4xzr B Reference
       Region 4xzr B 88-509 order
Seq 88-510 Hetero dimer : Q02724
 Evidence X-RAY 5h2x A Reference
       Region 5h2x A 88-465 order
       Region 5h2x A 466-470 disorder
       Region 5h2x A 471-510 order
 Evidence X-RAY 5h2w C Reference
       Region 5h2w C 88-88 disorder
       Region 5h2w C 89-463 order
       Region 5h2w C 464-470 disorder
       Region 5h2w C 471-509 order
       Region 5h2w C 510-510 disorder
 Evidence X-RAY 5h2w A Reference
       Region 5h2w A 88-88 disorder
       Region 5h2w A 89-465 order
       Region 5h2w A 466-470 disorder
       Region 5h2w A 471-509 order
       Region 5h2w A 510-510 disorder
Seq 88-530 Hetero dimer : IID50007Complex
 Evidence X-RAY 1un0 B Reference
       Region 1un0 B 88-526 order
       Region 1un0 B 527-530 disorder
 Evidence X-RAY 1un0 A Reference
       Region 1un0 A 88-526 order
       Region 1un0 A 527-530 disorder
Seq 88-541 Hetero dimer : IID50007Complex
 Evidence X-RAY 2c1t B Reference
       Region 2c1t B 88-510 order
       Region 2c1t B 511-541 disorder
 Evidence X-RAY 2c1t A Reference
       Region 2c1t A 88-510 order
       Region 2c1t A 511-541 disorder
Seq 89-510 Hetero trimer :
 Evidence X-RAY 1bk6 B Reference
       Region 1bk6 B 89-510 order
Seq 89-510 Homo dimer :
 Evidence X-RAY 1bk5 B Reference
       Region 1bk5 B 89-510 order
 Evidence X-RAY 1bk5 A Reference
       Region 1bk5 A 89-510 order
Seq 89-510 Hetero trimer :
 Evidence X-RAY 1bk6 A Reference
       Region 1bk6 A 89-510 order
SeqProS possible 12-19,31-58 Same region of mouse homolog (P52293, 57%identity) is disordered in the free state Hetero trimer : IID50075Complex,IID50081Complex
       Region 1wa5 B 12-19 order
       Region 1wa5 B 31-58 order
Seqacetylation
    1-1 N-acetylmethionine
 
Prediction
NeProc
Disorder 1-28,57-85,517-542
Order 29-56,86-512
ProS 12-28,57-59,524-542
AlphaFold
Disorder 1-27,49-75,512-542
Order 28-48,76-511
Pfam Hmmer
PF01749 9-110 1.1e-45
PF00514 119-160 1.2e-12
PF00514 162-202 7e-12
PF00514 204-244 1.9e-09
PF00514 246-286 3.3e-07
PF00514 288-328 4.2e-08
PF00514 330-370 2.2e-14
PF00514 372-412 5.1e-13
PF00514 417-457 5.9e-06
SEG 66-74 ,84-96
Function
Function in SwissProt
Functions in nuclear protein import as an adapter protein for importin beta nuclear receptors (PubMed:10913188). Binds specifically and directly to substrates containing either a simple or bipartite NLS motif (PubMed:10745017). Promotes docking of import substrates to the nuclear envelope (PubMed:8521485). Together with importin beta KAP95, mediates nuclear import of transcription factor GCN4 (PubMed:14648200). Together with tethering factor STS1, targets the proteasome to the nucleus (PubMed:10913188, PubMed:21075847).