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IID50013
 UniprotQ29495
ProteinSerotonin N-acetyltransferase
GeneAANAT
OrganismOvis aries
Sequence LLPS PhaSepDB
PhaSePro
LLPSDB
DrLLPS
 Network xml rdf
Structure
Experiment
  :order   disorder   conflict   PDB cluster   ProS   Pfam Domain   SEG
207
 order/disorder by at least rule
     disorder by at least rule
     order by at least rule
 order/disorder by majority rule
Seq 1-207 Monomer :
 Evidence X-RAY 1l0c A Reference
       Region 1l0c A 1-29 disorder
       Region 1l0c A 30-195 order
       Region 1l0c A 196-207 disorder
 Evidence X-RAY 1kuy A Reference
       Region 1kuy A 1-29 disorder
       Region 1kuy A 30-195 order
       Region 1kuy A 196-207 disorder
 Evidence X-RAY 1kux A Reference
       Region 1kux A 1-29 disorder
       Region 1kux A 30-195 order
       Region 1kux A 196-207 disorder
 Evidence X-RAY 1kuv A Reference
       Region 1kuv A 1-29 disorder
       Region 1kuv A 30-195 order
       Region 1kuv A 196-207 disorder
 Evidence X-RAY 1cjw A Reference
       Region 1cjw A 30-195 order
 Evidence X-RAY 1b6b B Reference
       Region 1b6b B 28-34 disorder
       Region 1b6b B 35-56 order
       Region 1b6b B 57-67 disorder
       Region 1b6b B 68-201 order
 Evidence X-RAY 1b6b A Reference
       Region 1b6b A 28-33 disorder
       Region 1b6b A 34-201 order
Seq 2-201 Hetero tetramer : IID00061Complex
 Evidence X-RAY 1ib1 H Reference
       Region 1ib1 H 2-17 disorder
       Region 1ib1 H 18-196 order
       Region 1ib1 H 197-201 disorder
 Evidence X-RAY 1ib1 G Reference
       Region 1ib1 G 2-17 disorder
       Region 1ib1 G 18-196 order
       Region 1ib1 G 197-201 disorder
Seq 2-201 Hetero tetramer : IID00061Complex
 Evidence X-RAY 1ib1 F Reference
       Region 1ib1 F 2-17 disorder
       Region 1ib1 F 18-196 order
       Region 1ib1 F 197-201 disorder
 Evidence X-RAY 1ib1 E Reference
       Region 1ib1 E 2-17 disorder
       Region 1ib1 E 18-196 order
       Region 1ib1 E 197-201 disorder
SeqProS verified 18-29 14-3-3 binding motif Hetero tetramer : IID00061Complex
       Region 1ib1 E 18-196 order
       Region 1ib1 F 18-196 order
       Region 1kuy A 1-29 disorder
SeqProS verified 18-29 14-3-3 binding motif Hetero tetramer : IID00061Complex
       Region 1ib1 G 18-196 order
       Region 1ib1 H 18-196 order
       Region 1kuy A 1-29 disorder
Seqphosphorylation
    31-31 Phosphothreonine; by PKA
    205-205 Phosphoserine; by PKA
 
Prediction
NeProc
Disorder 1-31,201-207
Order 32-200
ProS 8-17,28-31,201-207
AlphaFold
Disorder 1-29,197-207
Order 30-196
Pfam Hmmer
PF00583 82-174 1.3e-13
Function
Function in SwissProt
Controls the night/day rhythm of melatonin production in the pineal gland. Catalyzes the N-acetylation of serotonin into N-acetylserotonin, the penultimate step in the synthesis of melatonin.
Biological Process
Diagram with PDB data
AANAT/YWHAZCRYSTAL STRUCTURE OF THE 14-3-3 ZETA:SEROTONIN N-ACETYLTRANSFERASE COMPLEX