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IID50016
 UniprotQ9JIH2
ProteinNuclear pore complex protein Nup50
GeneNup50
OrganismMus musculus
Sequence LLPS PhaSepDB
PhaSePro
LLPSDB
DrLLPS
 Network xml rdf
Structure
Experiment
  :order   disorder   conflict   PDB cluster   ProS   Pfam Domain   SEG
466
 order/disorder by at least rule
     disorder by at least rule
     order by at least rule
 order/disorder by majority rule
Seq 1-46 Hetero dimer : IID50009Complex
 Evidence X-RAY 2c1m B Reference
       Region 2c1m B 1-46 order
Seqdisorder 47-109
 Evidence X-RAY Reference
       Region 47-109 disorder
SeqProS possible 1-46 This region binds to importin alpha competing with NLS Hetero dimer : IID50009Complex
       Region 2c1m B 1-46 order
Seqphosphorylation
    52-52 Phosphoserine
    294-294 Phosphoserine
    268-268 Phosphoserine
    246-246 Phosphothreonine
    234-234 Phosphoserine
    208-208 Phosphoserine
Seqacetylation
    8-8 N6-acetyllysine
    126-126 N6-acetyllysine
    82-82 N6-acetyllysine
    448-448 N6-acetyllysine
 
Prediction
NeProc
Disorder 1-350
Order 351-434,440-466
ProS 4-18,38-42,113-118,160-204
AlphaFold
Disorder 1-4,8-8,18-27,43-151,203-351
Order 5-7,9-17,28-42,152-202,352-466
Pfam Hmmer
PF00638 349-466 9.9e-08
SEG 36-48 ,60-84 ,277-302 ,305-353
Function
Function in SwissProt
Component of the nuclear pore complex that has a direct role in nuclear protein import (PubMed:10811608). Actively displaces NLSs from importin-alpha, and facilitates disassembly of the importin-alpha:beta-cargo complex and importin recycling (PubMed:16222336). Interacts with regulatory proteins of cell cycle progression including CDKN1B (PubMed:10891500, PubMed:10811608). This interaction is required for correct intracellular transport and degradation of CDKN1B (PubMed:10811608).