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IID50017
 UniprotQ9YGY0
ProteinAxin-1
Geneaxin1
OrganismXenopus laevis
Sequence LLPS PhaSepDB
PhaSePro
LLPSDB
DrLLPS
 Network xml rdf
Structure
Experiment
  :order   disorder   conflict   PDB cluster   ProS   Pfam Domain   SEG
842
 order/disorder by at least rule
     disorder by at least rule
     order by at least rule
 order/disorder by majority rule
Seq 435-504 Hetero dimer : IID00039Complex
 Evidence X-RAY 1qz7 B Reference
       Region 1qz7 B 435-465 disorder
       Region 1qz7 B 466-482 order
       Region 1qz7 B 483-504 disorder
SeqProS possible 466-482 This region interacts with armagillo repeat. Hetero dimer : IID00039Complex
       Region 1qz7 B 466-482 order
 
Prediction
NeProc
Disorder 1-79,217-759
Order 80-128,135-216,760-842
ProS 4-38,59-73,217-223,235-251,284-332,338-345,353-401,406-419,448-457,464-488,499-504,532-535,550-573,585-589,637-655,686-690,704-708,724-730
AlphaFold
Disorder 1-79,129-131,214-351,360-382,420-467,484-635,652-707,710-710,713-713,715-760
Order 80-128,132-213,352-359,383-419,468-483,636-651,708-709,711-712,714-714,761-842
Pfam Hmmer
PF00615 88-211 4.7e-08
PF00778 760-842 2.1e-39
SEG 225-236 ,537-553 ,656-668 ,708-718 ,731-739
Function
Function in SwissProt
Component of the beta-catenin destruction complex required for regulating ctnnb1 levels through phosphorylation and ubiquitination, and modulating Wnt-signaling. Controls dorsoventral patterning via two opposing effects; down-regulates ctnnb1 to inhibit the Wnt signaling pathway and ventralize embryos, but also dorsalizes embryos by activating a Wnt-independent JNK signaling pathway.